I have had several experiences with DOI in the recent past and can say that it is quite a chemical. Most definately my favorite phenethylamine so far (I have taken 2C-B and 2C-I several times in the past). The effects don't really remind me of either 2c-b or 2c-i, but the visuals are relatively simliar to 2c-i.
DOI
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 5 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 30 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Research-chemical
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 5 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 30 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Research-chemical
Summary
DOI is an extremely potent and long-lasting psychedelic with a very sensitive dose-response curve. It is sometimes sold falsely as LSD, which can be dangerous due to differing safety profiles and dosage ranges. Use a precise milligram scale for accurate dosing.
Perspectives
“There was a nice spacey light-headedness for a few hours, and time seemed to move quite slowly. Then a generic sadness came over me, as I reminisced about earlier days (recalling pleasures now gone) and wondered if I would be allowed to be here on the Farm when I am old and not important. There is so much to be done, and I cannot do it all, and no one else cares. My mood became present-day and healthy by about the seventh hour.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 0.5-1mg | 1-2mg | 2-3mg | 3mg+ |
Light
Common
Strong
Heavy
Sources
Oral
Dose ladder — dose.wiki, PsychonautWikiOnset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 1-2 hrs | 1.5-3 hrs | 3-6 hrs | 6-12 hrs | 16-30 hrs |
Effect Profile
42 reportsScores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Validated against 25 Erowid trip reports
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
8.5
Intense
8/10
Strong visuals, headspace, and auditory effects with strong body load
Visual Intensity
×3
10
visual geometry
colour enhancement
drifting
tracers
pattern recognition enhancement
brightened colour
Headspace Depth
×3
10
conceptual thinking
thought connectivity
emotion enhancement
time distortion
confusion
Auditory Effects
×1
8
Body Load / Somatic Effects
×1
10
nausea
vasoconstriction
muscle tension
Stimulant
6.8
Strong+
7/10
Strong stimulation and euphoria with strong anxiety/jitters, low focus
Stimulation / Energy
×3
10
stimulation
wakefulness
Euphoria / Mood Lift
×2
9
cognitive euphoria
euphoria
Focus / Productivity
×2
3
thought acceleration
Anxiety / Jitters
×1
10
anxiety
restlessness
vasoconstriction
muscle tension
Based on reports from:
Tolerance
Build-up
develops rapidly; very long duration provides natural spacing
Reset
7–14 days for baseline
Tolerance Decay
Full tolerance
1h
Half tolerance
10d
Baseline
~14d
Effects
Aggregated from 25 single-substance Erowid and 17 Bluelight experience reports; 17 Erowid reports where another drug was taken too are left out
Each bar shows the share of analyzed reports whose text mentions that effect — a mention is not always a first-hand experience (fear of an effect or something witnessed can count). Mentions saying the effect did not happen are left out; that check reads keywords, so it can miss some. The shaded band on a bar, and the small range after its number, is the 95% interval: where the share could plausibly be with other reports of the same kind. Fewer reports, wider band. Tap or hover any number for details. The second value is the Bluelight extractor's per-effect confidence; a dash means the row is Erowid-derived, which has no confidence measurement.
Rows resting on fewer than 20 reports show a count (“3 of 7”) instead of a bar. Why 20?
Effect glossary — · full glossary
Positive Effects 46
50.0% (95% interval 36 to 64 percent)
82%
42.9% (95% interval 29 to 58 percent)
80%
33.3% (95% interval 21 to 48 percent)
86%
23.8% (95% interval 14 to 38 percent)
92%
23.8% (95% interval 14 to 38 percent)
86%
21.4% (95% interval 12 to 36 percent)
88%
21.4% (95% interval 12 to 36 percent)
80%
16.7% (95% interval 8 to 31 percent)
79%
16.0% (95% interval 6 to 35 percent)
–
14.3% (95% interval 7 to 28 percent)
85%
14.3% (95% interval 7 to 28 percent)
85%
9.5% (95% interval 4 to 22 percent)
85%
9.5% (95% interval 4 to 22 percent)
85%
4 of 17
90%
4 of 17
82%
4 of 17
85%
3 of 17
82%
3 of 17
83%
3 of 17
88%
3 of 17
82%
Show 26 more positive effects
2 of 17
82%
2 of 17
88%
2 of 17
85%
2 of 17
85%
2 of 17
90%
2 of 17
85%
2 of 17
85%
2 of 17
88%
2 of 17
82%
1 of 17
85%
1 of 17
90%
1 of 17
85%
1 of 17
80%
1 of 17
85%
1 of 17
75%
1 of 17
80%
1 of 17
90%
1 of 17
90%
1 of 17
85%
1 of 17
75%
1 of 17
75%
1 of 17
80%
1 of 17
80%
1 of 17
85%
1 of 17
90%
1 of 17
85%
Adverse Effects 36
28.6% (95% interval 17 to 44 percent)
88%
20.0% (95% interval 9 to 39 percent)
–
19.0% (95% interval 10 to 33 percent)
85%
5 of 17
86%
4 of 17
78%
3 of 17
87%
2 of 17
85%
2 of 17
80%
2 of 17
88%
2 of 17
88%
2 of 17
88%
2 of 17
75%
2 of 17
78%
2 of 17
82%
2 of 17
85%
2 of 17
82%
2 of 17
80%
1 of 17
80%
1 of 17
75%
1 of 17
85%
Show 16 more adverse effects
1 of 17
90%
1 of 17
85%
1 of 17
90%
1 of 17
75%
1 of 17
90%
1 of 17
85%
1 of 17
85%
1 of 17
75%
1 of 17
90%
1 of 17
80%
1 of 17
75%
1 of 17
90%
1 of 17
80%
1 of 17
85%
1 of 17
90%
1 of 17
75%
Also reported in combinations. In the 17 DOI reports where another drug was taken too, 3 mention hospital, emergency services or an overdose, 0 a seizure and 1 psychosis (too few reports for percentages). In the 25 single-substance reports: 12.0%, 0.0% and 8.0%. These are not in the figures above: they cannot be put down to DOI alone, and a mention is not always something that happened to the writer.
Combinations
Cross-Check DOI with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 8 reports 5 positive 2 neutral 1 cautionary visit
Set and setting: A beautiful warm sunny day. I took the day off of work in order to experiment and enjoy the spring weather. My intent was to take something moderately visual, and then go outside in the park if I felt okay. I was also looking for some insight into intrapersonal relationships.
If you are here just for some quick facts, skip to the 'summary of findings' section below. Yesterday I had the privilege to experience DOI for the first time. I was at home and able to control the set and setting the way I wanted it. I started out with a small dose which turned out to be just the right amount for me.
This research chemical was acquired relatively cheaply, and saved until a special sunday. The story goes like this: Saturday night: alarm set for 6 am sunday. Sunday, 6 AM: consume blotter, return to sleep. Sunday, 9 AM: awake. Very definite psychedaelia present.
The Basics: Subject: Twenty-five year old white male. Recently quit smoking (again). Overweight, but in very good health according to the latest physical. Substance: 8mg of DOI in a 1:1(ml) solution of vodka.
First I should say this report is mostly intended for people with some psychedelic experience. I don't really have time to delve into each and every insight. 2:00pm I ingest 2mg of DOI by licking it off a credit card. Then I go on a few quick errands. 3:00pm Back from my errands. First alerts? Maybe slightly.
A friend had acquired some blotter which he had tried recently in a low dosage and believed to be LSD. It was unperforated, and on thick blotter. I would normally take 4 or 5 hits of blotter, so I just ripped off a fat piece and started sucking on it.
[Erowid Note: Driving while intoxicated, tripping, or extremely sleep deprived is dangerous and irresponsible because it endangers other people. Don't do it! ] I got home, and assured my friend I would be alright and he left.
Bluelight 8 threads 3 positive 4 neutral 1 cautionary visit
extended DOI trip with others(70 hour trip) the other day i was lucky enough to come by some DOI and thought it would be a good idea to put it to the test in a festival environment because of its longevity.i was in a good mood with 3 other people,2 of whom joined me and 1 who didnt.
The Basics: Subject: Twenty-five year old white male. Recently quit smoking (again). Overweight, but in very good health according to the latest physical. Substance: 8mg of DOI in a 1:1(ml) solution of vodka.
DOI TR #1 Substance: DOI Dosage: 3 mg oral Gender: Male Weight: 83 kg Height: 178 cm Age: 26 Set and setting: House in the countryside in the hot summer, with few friends, good mood, some apprehensions of what happens when taking such powerful substance Rating: 7/10 Previous experiences: * Weed (many times) * Shrooms (...
This trip was several months ago, probably september or october 2005. It was the fourth time I used DOI, if I remember right. It was also the highest dose I have taken and I don't think I will go this high again. This is where I started to notice the side effects, though they were not very bad.
DOI (2.4?mg) / Valerian Root - First Time - "An Ending" Material - DOI, 2 and 1/3 blotters Setting - My apartment mostly. Background - A drug user for less than a year, am 21 now. I have done a whole host of substances, legal and otherwise.
Here is a brief synopsis of a trip I took yesterday that has forever changed the world for me. I had stayed up all night redosing methylone and BDB. Around 7AM I swallowed 2mg of DOI in liquid solution, while still feeling the BDB strongly and a tiny bit of methylone stimulation.
DOI - First time - A useful tool, nice I dissolved 30mg of DOI into solution to measure and took about 3mg at 6:10. 6:35 - I think I feel different, possibly more alert, yet calm. A comfortable mental stimulation (nothing felt in the body). 7:10 - Mild trails can be seen for the last 10 minutes or so.
25yr old male / 165lbs / 2mg clonazepam daily (anxiety) previously used: mushrooms, coke, mdma, dxm (current fave), 2ci, 2ct2, 5meoDMT ---------- 3mg DOI oral [100mg DOI dissolved in 100ml vodka ... put 3ml in my ice tea. nice weekday night cozy with gf.
Bluelight Reference Guide
☛ Official ☚ The Big and Dandy DOI Thread
External Information Links: Erowid DOI Vault (experience reports) PIHKAL Entry for DOI Wikipedia entry DOX Safety Discussion Thread Original post: You know im not sure if there is one of these threads already but i couldnt find one. If there is, sorry for starting a new one...
Read full thread on Bluelight →PiHKAL / TiHKAL
PiHKAL #67: DOI
“There was a nice spacey light-headedness for a few hours, and time seemed to move quite slowly. Then a generic sadness came over me, as I reminisced about earlier days (recalling pleasures now gone) and wondered if I would be allowed to be here on the Farm when I am old and not important. There is so much to be done, and I cannot do it all, and no one else cares. My mood became present-day and healthy by about the seventh hour.”
DOI's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
Import into PsychonautWiki Journal
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