Effect Glossary
Plain-language definitions of the 513 subjective and physical effects named across this site — 231 from the Dose.wiki effect index, 282 written for this site where the index has no entry. Effect names on substance pages link here. Definitions describe what an effect is — not a promise of what any substance will do.
A
Abnormal heartbeat Dose.wiki
An abnormal heartbeat is any of a group of conditions in which the electrical activity of the heart is irregular. During this state, the heartbeat may be too fast (over 100 beats per minute) or too slow (less than 60 beats per minute) and may be regular or irregular. An abnormal heartbeat is most commonly induced under the influence of moderate dosages of stimulant and depressant compounds, such as cocaine, methamphetamine, and GABAergics.
Abrupt return of consciousness Substance Search
An abrupt return of consciousness is the experience of ordinary awareness snapping back suddenly rather than fading in gradually. One moment the person is absent or deep in an altered state, and the next they are fully back in the room, sometimes with brief confusion about where they are or how much time has passed. It is most often described after short-acting experiences that end as quickly as they began.
Acceptance Substance Search
Acceptance is a felt sense of being at peace with oneself, one's circumstances, or past events that are normally sources of struggle or resistance. Things that usually provoke worry or self-criticism may feel acknowledged and settled rather than fought against. The sense of resolution felt during intoxication does not always persist once the experience ends.
Acid reflux Substance Search
Acid reflux is the backward flow of stomach acid into the esophagus, the tube connecting the mouth and stomach. It typically manifests as a burning sensation in the chest or throat, a sour taste in the mouth, or burping and regurgitation, and often worsens when lying down or after eating.
Acne and oily skin Substance Search
Acne and oily skin is an increase in the skin's oil production, often accompanied by new or worsening breakouts on the face, chest, shoulders, or back. The skin may look shiny and feel greasy within hours of washing. It generally builds up over days to weeks of use rather than appearing after a single dose.
Addiction suppression Dose.wiki
Addiction suppression can be described as the experience of a total or partial suppression of a psychological addiction to a specific substance and the cravings associated with it. It is a rare effect that is most commonly associated with psychedelics, psilocin, LSD, ibogaine, and N-acetylcysteine (NAC).
After images Dose.wiki
After images (also known as palinopsia) are visual perceptions that continue to appear in one's vision after exposure to the original image has ceased. They are most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Afterglow Substance Search
Afterglow can be described as a lingering positive shift in mood, energy, or outlook that persists after a substance's direct effects have ended, sometimes lasting hours to days. It is typically described as elevated mood, mental clarity, or a sense of ease, and is commonly reported following psychedelic and entactogenic experiences.
Aggression Substance Search
Aggression is an increase in hostile feelings or behavior, ranging from irritability and verbal confrontation to, in severe cases, physical violence. It is sometimes reported in connection with heavy alcohol use, high-dose stimulant use, and extended sleep deprivation, and it is regarded as a serious adverse effect because of the risk it poses to the person and to others.
Agitation Substance Search
Agitation is a state of inner tension and restlessness that drives excessive, often purposeless movement such as pacing, fidgeting, or an inability to stay still. It is frequently accompanied by irritability and can escalate into distress. It is commonly reported under stimulants and during withdrawal from depressants.
Akathisia Substance Search
Akathisia is a state of severe inner restlessness combined with a compelling urge to move. It typically manifests as an inability to sit or stay still, with pacing, rocking, or constant shifting of the legs, and is usually experienced as intensely distressing. It is a clinically recognized reaction most commonly associated with antipsychotics and some other dopamine-affecting medications.
Amnesia Dose.wiki
Amnesia is a global impairment in the ability to acquire new memories regardless of sensory modality, and a loss of some memories, especially recent ones, from the period before amnesia began. It is most commonly induced under the influence of heavy dosages of GABAergic depressants, such as alcohol, benzodiazepines, GHB, and zolpidem.
Analysis enhancement Dose.wiki
Analysis enhancement is a perceived improvement of a person's overall ability to logically process information or creatively analyze concepts, ideas, and scenarios. It is most commonly induced under the influence of moderate dosages of stimulant and nootropic compounds, such as amphetamine, methylphenidate, nicotine, and caffeine.
Analysis suppression Dose.wiki
Analysis suppression is a distinct decrease in a person's overall ability to process information and logically or creatively analyze concepts, ideas, and scenarios. It is most commonly induced under the influence of heavy dosages of antipsychotic compounds, and is associated with long term use of such drugs like quetiapine, haloperidol, and risperidone.
Anger Substance Search
Anger is a state of heightened irritation, hostility, or aggression that can range from mild annoyance to intense rage. It may arise with little provocation and feel harder to control than usual. It is commonly reported during stimulant comedowns and during withdrawal from a range of substances.
Anhedonia Substance Search
Anhedonia is a reduced ability to feel pleasure or interest in activities that are normally enjoyable. It can manifest as emotional flatness, low motivation, and finding food, music, socializing, or hobbies less rewarding than usual. It is commonly reported during comedowns and withdrawal.
Anticipation Substance Search
Anticipation is a state of heightened expectation about something that is about to happen, felt as excitement, restlessness, or nervousness. In substance contexts it is often strongest during the onset period, before the main effects arrive. It can color the early part of an experience in either a pleasant or an anxious direction.
Anticipatory response Dose.wiki
An anticipatory response is the experience of a wide range of potential cognitive and physical effects that can occur immediately before the administration of a substance that the user is experienced with or addicted to.
Anxiety Dose.wiki
Anxiety is medically recognized as the experience of negative feelings of apprehension, worry, and general unease. It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as cannabinoids, psychedelics, dissociatives, and deliriants.
Anxiety suppression Dose.wiki
Anxiety suppression (also known as anxiolysis or minimal sedation) is medically recognized as a partial to complete suppression of a person’s ability to feel anxiety, general unease, and negative feelings of both psychological and physiological tension. It is most commonly induced under the influence of moderate dosages of anxiolytic compounds which primarily include GABAergic depressants, such as benzodiazepines, alcohol, GHB, and gabapentinoids.
Apathy Substance Search
Apathy is a decrease in motivation, interest, and emotional engagement with activities and events that would normally feel meaningful. It typically manifests as indifference toward responsibilities, hobbies, and social contact rather than as active sadness. It is commonly reported during comedowns and withdrawal, and as a longer-lasting effect of sustained heavy use of some substances.
Appetite enhancement Dose.wiki
Appetite enhancement (also known as "the munchies") can be described as the experience of a distinct increase in a person's sense of hunger and appetite. It is most commonly induced under the influence of moderate dosages of orexigenic compounds, such as cannabinoids, mirtazapine, and quetiapine.
Appetite fluctuation Substance Search
Appetite fluctuation is a shifting of hunger up and down over the course of an experience, rather than a steady increase or decrease. A person may feel no interest in food at one point and unexpectedly hungry at another, sometimes within a short span of time.
Appetite suppression Dose.wiki
Appetite suppression can be described as the experience of a distinct decrease in a person's sense of hunger and appetite in a manner which can result in both a lesser desire to eat food and a decreased enjoyment of its taste. It is most commonly induced under the influence of moderate dosages of stimulant compounds, such as amphetamine, methylphenidate, nicotine, MDMA, and cocaine.
Artifacting Substance Search
Artifacting is a visual effect in which the field of vision seems to contain glitches such as pixelation, blockiness, or repeating fragments, resembling errors in a compressed digital image. Edges may double or shimmer, and textures can look tiled, smeared, or corrupted. The scene usually remains recognizable beneath the apparent errors.
Auditory delay Substance Search
Auditory delay is the perception that sounds arrive later than the events producing them, as if hearing is lagging slightly behind reality. Speech and music may seem out of sync with lips or movements, or a sound may appear to repeat or trail off after its source has stopped. It is usually most noticeable during conversation or while listening to music.
Auditory distortion Dose.wiki
An auditory distortion is the experience of perceived alterations in how audible noises present and structure themselves. They are most commonly induced under the influence of hallucinogenic compounds.
Auditory enhancement Dose.wiki
An auditory enhancement is the experience of an increase or improvement of the acuteness and clarity of sound. They are most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Auditory hallucination Dose.wiki
An auditory hallucination is the experience of hearing spontaneous and imaginary noises. They are most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics, deliriants, and dissociatives.
Auditory misinterpretation Dose.wiki
Auditory misinterpretation is the fleeting experience of a sound or noise being mistaken as something else. It is most commonly induced under the influence of moderate dosages of deliriant compounds, such as DPH, datura, and benzydamine.
Auditory suppression Dose.wiki
Auditory suppression is the experience of sound becoming perceived as more distant, quiet, and muffled than they actually are. It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Autonomous entity Dose.wiki
An autonomous entity is the experience of perceived contact with beings that appear to be sentient in their behaviour. They are most commonly induced under the influence of heavy dosages of hallucinogenic compounds.
Autonomous voice communication Dose.wiki
Autonomous voice communication is the experience of being able to hear and converse with a disembodied and audible voice of unknown origin which seemingly resides within one's own head. It is most commonly induced under the influence of heavy dosages of hallucinogenic compounds such as psychedelics, dissociatives, and deliriants.
Awe Substance Search
Awe is an emotional state of intense wonder and reverence, often felt in response to something perceived as vast, beautiful, or beyond ordinary understanding. During substance experiences it can be triggered by things that would normally seem mundane, such as music, nature, or everyday objects, and it may be accompanied by chills, tears, or a sense of smallness before something larger.
B
Back pain Dose.wiki
Back pain can be described as feelings of aches and pain located throughout a person's back. It is most commonly induced under the influence of heavy dosages of stimulating psychedelics compounds, such as LSD, 2C-B, and mescaline.
Balance changes Substance Search
Balance changes are alterations in the sense of physical equilibrium, felt as swaying, tilting, unsteadiness on the feet, or a sensation that the ground is shifting. Walking in a straight line, standing with eyes closed, or turning quickly may become noticeably harder. Because they raise the chance of trips and falls, they are worth accounting for before moving around.
Bodily control enhancement Dose.wiki
Bodily control enhancement can be described as feeling as if there has been a distinct increase in a person's ability to control their physical body with precision, balance, coordination, and dexterity. It is most commonly induced under the influence of moderate dosages of stimulating psychedelics, such as LSD, 2C-B, and DOC.
Bodily pressures Dose.wiki
Bodily pressures can be described as the physical experience of spontaneous pressures across different parts of the body. They are most commonly induced under the influence of heavy dosages of stimulating psychedelics, such as 2C-E, DPT, and 5-MeO-DMT.
Body aches Substance Search
Body aches are diffuse muscular soreness or pain felt across much of the body rather than in one specific spot. They are commonly reported during comedowns and withdrawal — notably opioid withdrawal — and after periods of drug-induced muscle tension or overexertion.
Body anxiety Substance Search
Body anxiety is anxiety that is focused on, or felt mainly in, the physical body. Attention narrows onto sensations such as heartbeat, breathing, temperature, or muscle tension, with worry that something may be wrong, and the monitoring itself often makes the sensations more noticeable. It is typically experienced as uncomfortable and self-reinforcing while it lasts.
Body energy Substance Search
Body energy is the sensation of a current, buzz, or charge moving through or settling in the body. It may be felt as tingling, warmth, vibration, or pressure that flows, pools, or radiates outward from the chest, spine, or limbs. Depending on its intensity, it can be experienced as pleasant, neutral, or restless.
Body image awareness Substance Search
Body image awareness is a heightened attention to one's own body — its size, shape, weight, or appearance — and to the thoughts and feelings attached to it. During an experience, the body can feel or look different from usual, and existing feelings about it may surface with unusual intensity, in either a comfortable or a distressing direction. The state usually recedes as attention moves elsewhere or the experience ends.
Body load Substance Search
Body load is a general term for the uncomfortable physical sensations that accompany a substance's effects, such as heaviness, tension, queasiness, or a vague sense of bodily strain. It describes the overall physical burden of an experience rather than any single symptom, and experiences with a heavy body load are often described as physically taxing even when the mental effects are manageable.
Body odour alteration Dose.wiki
Body odour alteration can be described as a distinct change in the body's natural odour that can occur in response to the ingestion of a psychoactive substance, nootropic, or medicine. It is most commonly induced under the influence of heavy dosages of stimulant compounds, such as methamphetamine and mephedrone which are often said to result in an ammonia-like odour.
Body swelling Substance Search
Body swelling is the sensation that parts of the body are inflating, growing, or larger than they actually are, without any real change in size. Hands, the face, or the whole body may feel puffed up or expanded, and the feeling can shift or move over time. It is a distortion of body perception rather than actual physical swelling.
Body warmth Substance Search
Body warmth is a sensation of comfortable heat spreading across or radiating through the body. It is often described as a gentle glow or flush accompanying physical relaxation, and is commonly reported under opioids and other depressants.
Boredom Substance Search
Boredom is an unpleasant state of restless disinterest in which one's surroundings and available activities feel unstimulating and unrewarding. In the context of substance experiences it is most often reported during long plateaus or comedowns, when time can feel as though it is passing unusually slowly.
Brain fog Substance Search
Brain fog is a subjective state of mental cloudiness in which thinking feels slow, unclear, and effortful. It typically manifests as difficulty concentrating, trouble finding words, forgetfulness, and a sense of being mentally dulled. It is commonly reported during comedowns, hangovers, and the days following heavy use, though it can also occur during a substance's active effects.
Brain zaps Dose.wiki
Brain zaps can be described as sharp electrical shock sensations which originate within the head or brain and sometimes extend throughout the body. They are most commonly induced under the influence of withdrawal, dose reduction, and discontinuation of antidepressant drugs, including selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs) such as sertraline, paroxetine, and venlafaxine.
Breast development Substance Search
Breast development is the growth of glandular breast tissue. It typically begins with tenderness, itching, or a firm lump beneath the nipple before any visible change in size, and it can occur in people of any sex in contexts involving hormonal changes.
Breathing awareness Substance Search
Breathing awareness is a heightened consciousness of one's own breathing, in which breaths that are normally automatic feel noticeable or deliberate. Some people experience it as neutral or even calming, while others find the sense of having to breathe manually uncomfortable or anxiety-provoking.
Brightness alteration Dose.wiki
Brightness alteration is a distortion or change in the intensity of perceived brightness comprising a person's vision. It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and cannabinoids.
Bronchodilation Dose.wiki
Bronchodilation can be described as the expansion of the bronchial air passages in the respiratory tract. A bronchodilator is a substance that dilates the bronchial tubes resulting in decreased resistance in the respiratory airway and increased airflow to the lungs.
Burning sensation Substance Search
Burning sensation is a feeling of heat, stinging, or irritation in the skin, nose, throat, or stomach without any external source of heat. It is commonly reported at the point of contact with a substance, for example in the nose after insufflation or in the throat and stomach after swallowing something irritating.
Butterflies in the stomach Substance Search
Butterflies in the stomach is a fluttering, swooping, or hollow sensation in the abdomen, usually tied to excitement, anticipation, or nervousness. It is often reported during the onset of a substance's effects, where it can be read as either thrill or unease. The sensation typically comes and goes rather than remaining constant.
C
Cardiovascular stimulation Substance Search
Cardiovascular stimulation is an increase in the activity of the heart and circulatory system, typically experienced as a faster or more forceful heartbeat and often accompanied by a rise in blood pressure. It is commonly associated with stimulating substances and can also be brought on by anxiety or exertion during an experience. At mild levels it may pass unnoticed, while at stronger levels it can feel uncomfortable and places extra strain on the heart.
Catalepsy Substance Search
Catalepsy is a state in which the body becomes rigid and holds whatever posture it is placed in, along with a decreased responsiveness to outside stimuli. A person experiencing it may remain motionless in a fixed position for an extended period while being only partially aware of their surroundings. It is commonly reported under heavy doses of dissociative substances.
Catatonia Substance Search
Catatonia is a state in which a person becomes markedly unresponsive to their surroundings while remaining physically awake, with a severe reduction or absence of movement and speech. It can involve rigid or unusually held postures, staring, and failure to react to outside stimuli. From the outside this state cannot be reliably distinguished from other causes of unresponsiveness, so it is treated as a medical emergency.
Catharsis Dose.wiki
Catharsis is a psychological state defined as an extremely therapeutic, healing, and intense release of repressed emotions in which many people describe reliving traumatic events, crying, witnessing painful memories, having enhanced mental imagery, and reliving past experiences. It is most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Changes in felt bodily form Dose.wiki
Changes in felt bodily form can be described as feelings of the body shifting in its perceived physical shape, organization and form in a manner which is typically devoid of accompanying visual alterations. They are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and Salvinorin A.
Changes in felt gravity Dose.wiki
Changes in felt gravity can be described as feeling that the pull of gravity has shifted in its direction. For example, during this state one may feel as if they are floating forwards, backwards, upwards, downwards, or in an unspecifiable direction.
Chest numbness Substance Search
Chest numbness is a reduced or absent sense of feeling in the chest area, which may be experienced as dullness, heaviness, or a sense that the chest is disconnected from the rest of the body. Breathing and heartbeat can feel muted or harder to sense than usual.
Chest pain Substance Search
Chest pain is an uncomfortable sensation of pressure, tightness, aching, or sharpness felt in the chest. It is commonly reported under stimulants and other substances that raise heart rate and blood pressure, where it can reflect anything from harmless muscle tension to serious cardiovascular strain. Severe, crushing, or persistent chest pain, especially with shortness of breath or pain spreading to the arm or jaw, is treated as a medical emergency.
Chest tightness Substance Search
Chest tightness is a sensation of pressure, constriction, or heaviness in the chest. It often stems from muscle tension or anxiety and is commonly reported under stimulants. Chest sensations cannot reliably be distinguished from cardiac symptoms by feel alone, so persistent or painful tightness warrants attention.
Chills Substance Search
Chills are sensations of coldness accompanied by shivering or goosebumps that occur without a matching drop in the surrounding temperature. They often appear alongside other disturbances of temperature regulation, such as sweating or flushing, and are commonly reported under stimulants and psychedelics as well as during opioid withdrawal.
Chromatic aberration Dose.wiki
Chromatic aberration is when the colours reflected off of an object's surface become distinctly split into three overlapping offset layers. These split layers can potentially be any colour, but are most commonly reported to be red, green, and blue. It is most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Clammy skin Substance Search
Clammy skin is skin that feels cool, damp, and sweaty to the touch, often accompanied by paleness. It results from sweating that is not driven by warmth and commonly accompanies nausea, anxiety, or physical distress. When pronounced, it is one of the outwardly visible signs that a person's body is under strain.
Claustrophobia Substance Search
Claustrophobia is a feeling of being enclosed or trapped, with anxiety rising in response to small spaces, crowds, or the sense that there is no exit. During a substance experience it can also attach to the state itself, felt as being unable to step out of the intoxication. It is typically experienced as distressing while it lasts.
Cognitive clarity Substance Search
Cognitive clarity is a perceived sharpening of mental processes in which thoughts feel unusually clear, ordered, and easy to follow. It is often described as a lifting of mental fog rather than an increase in energy, and the felt clarity does not always match actual performance. It is commonly reported under stimulants and nootropics.
Cognitive disconnection Dose.wiki
Cognitive disconnection is the experience of feeling distant and detached from one's sense of identity, thought stream, and general cognitive processes. It is a near-universal effect under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Cognitive dysphoria Dose.wiki
Cognitive dysphoria (semantically the opposite of euphoria) is medically recognized as a cognitive and emotional state in which a person experiences intense feelings of dissatisfaction, and in some cases indifference to the world around them. It is most commonly induced under the influence of moderate dosages of deliriant compounds, such as DPH and datura. However, it can also occur during a stimulant's offset and during the withdrawal symptoms of almost any substance.
Cognitive enhancement Substance Search
Cognitive enhancement is a perceived overall improvement in mental functioning, which can include faster thinking, easier concentration, and greater motivation. The felt improvement does not always match actual performance, which may be unchanged or even reduced. It is commonly reported under stimulants and nootropics.
Cognitive euphoria Dose.wiki
Cognitive euphoria (semantically the opposite of cognitive dysphoria) is medically recognized as a cognitive and emotional state in which a person experiences intense feelings of well-being, elation, happiness, excitement, and joy. It is most commonly induced under the influence of moderate dosages of opioids, entactogens, stimulants, and GABAergic depressants. However, it can also occur to a lesser extent under the influence of hallucinogenic compounds such as psychedelics, dissociatives, and cannabinoids.
Cognitive fatigue Dose.wiki
Cognitive fatigue (also called exhaustion, tiredness, lethargy, languidness, languor, lassitude, and listlessness) is medically recognized as a state usually associated with a weakening or depletion of one's mental resources. It is most commonly induced under the influence of moderate dosages of antipsychotic compounds, such as quetiapine, haloperidol, and risperidone.
Cognitive impairment Substance Search
Cognitive impairment is a general reduction in mental performance, affecting abilities such as attention, memory, reasoning, and processing speed. It can range from mild difficulty concentrating to a state in which coherent thought becomes difficult, and it may persist into the period after a substance's main effects have ended. It is commonly reported at heavier doses of many substance classes, particularly depressants and dissociatives.
Cold extremities Substance Search
Cold extremities can be described as the hands, feet, fingers, or toes feeling unusually cold, sometimes accompanied by numbness, tingling, or a pale or bluish appearance of the skin. It typically results from reduced blood flow to the limbs and is commonly reported under compounds that narrow the blood vessels, such as many stimulants.
Cold flashes Substance Search
Cold flashes are sudden waves of coldness or chills that pass over the body, often with shivering or goosebumps, without any real change in the surrounding temperature. They typically come and go in waves and may alternate with hot flashes. They are commonly reported under entactogens and during withdrawal from some substances.
Cold sweats Substance Search
Cold sweats are episodes of sweating that occur together with chills or cool, clammy skin rather than a feeling of warmth. They often come in waves alongside nausea, shakiness, or feeling faint, and are commonly reported during comedowns, withdrawal, and other physically stressful stretches of an experience.
Color bleeding Substance Search
Color bleeding is a visual distortion in which the color of an object appears to spread or run past its physical edges, tinting the surrounding area the way wet ink bleeds into paper. It is commonly reported during psychedelic experiences and is usually most noticeable around brightly colored or high-contrast objects.
Colour distortion Substance Search
Colour distortion is a change in how colours are perceived, such as hues appearing shifted, unnaturally intense, washed out, or different from how the person knows them to be. Familiar objects may take on tints they do not normally have, or the overall scene may seem filtered through a particular shade. The effect concerns colour only; the shapes and positions of objects remain as they are.
Colour enhancement Dose.wiki
Colour enhancement is a perceived intensification of the brightness and vividness of colours in the external environment. It is most commonly induced under the influence of mild dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Colour replacement Dose.wiki
Colour replacement is the experience of a person's entire visual field or specific objects and sections within it becoming replaced with an alternative colour that differs from its original appearance. It is most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Colour shifting Dose.wiki
Colour shifting is when objects within the environment fluidly change their colour through a continuously repeating cycle. It is most commonly induced under the influence of psychedelic compounds.
Colour suppression Dose.wiki
Colour suppression is the experience of colours becoming darker, less saturated, and less distinguishable from one another. It is most commonly induced under the influence of heavy dosages of antipsychotic compounds, such as quetiapine, haloperidol, and risperidone.
Colour tinting Substance Search
Colour tinting is a visual effect in which the field of vision takes on a uniform tint of a particular colour, as if viewed through coloured glass. Objects otherwise keep their normal appearance, but their colours are shifted toward the tinting hue. It is commonly reported under psychedelics.
Comedown Substance Search
A comedown is the transitional period in which a substance's main effects wear off and the person returns toward their ordinary state. It is often accompanied by fatigue, low mood, irritability, or mental dullness, roughly opposite in character to the effects that preceded it. Comedowns vary widely in length and intensity and are most commonly reported after stimulating or euphoric substances.
Communication enhancement Substance Search
Communication enhancement is a perceived increase in the ease and enjoyment of talking with others. People often report finding words more readily, feeling more open, and connecting with conversation partners more easily than usual. It is commonly reported under entactogens and at lower doses of some depressants.
Complex visual imagery Substance Search
Complex visual imagery is the experience of detailed pictures, scenes, or structured forms appearing in the mind's eye or within one's visual field, with eyes open or closed. Unlike simple geometric patterns, it can include recognizable content such as landscapes, objects, faces, or entire unfolding scenes. It is most commonly reported with psychedelic compounds, particularly at higher doses or with closed eyes.
Component controllability Dose.wiki
Component controllability is the rare experience of gaining partial or complete conscious control over the details, content, and intensity of other currently occurring subjective effects. It is a very rare experience that mostly occurs under the influence of heavy dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Compulsive behavior Substance Search
Compulsive behavior is the repetition of an action past the point of usefulness or conscious intention, often with a feeling of being unable to stop. It can manifest as repetitive fidgeting, skin-picking, rearranging objects, or repeatedly taking more of a substance. It is commonly reported under stimulants.
Compulsive redosing Dose.wiki
Compulsive redosing is the experience of a powerful and difficult to resist urge to continuously redose a psychoactive substance in an effort to increase or maintain the subjective effects which it induces. It is most commonly induced under the influence of moderate dosages of a wide variety of compounds, such as opioids, stimulants, GABAergics, and entactogens.
Conceptual thinking Dose.wiki
Conceptual thinking is an alteration to the nature and content of one's internal thought stream. This alteration predisposes a user to think thoughts that are no longer primarily comprised of words and linear sentence structures. Instead, thoughts become equally comprised of what is perceived to be extremely detailed renditions of the innately understandable and internally stored concepts that words exist to label. It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics and dissociatives.
Confidence enhancement Substance Search
Confidence enhancement is a perceived increase in self-assurance and belief in one's own abilities. It typically manifests as reduced social inhibition, greater willingness to speak or act, and a decreased fear of judgement or failure. It is commonly reported under stimulants, entactogens, and low doses of depressants such as alcohol.
Confusion Dose.wiki
Confusion is an impairment of abstract thinking demonstrated by an inability to think with one’s customary clarity and coherence. It is most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, dissociatives, synthetic cannabinoids, and deliriants.
Constipation Dose.wiki
Constipation can be described as bowel movements that are infrequent or hard to pass. It usually results in painful defecation and small, compact faeces. It is most commonly induced under the influence of heavy dosages of opioid compounds, such as heroin, tramadol, fentanyl, and kratom.
Contrast enhancement Substance Search
Contrast enhancement is a visual effect in which the difference between the light and dark areas of a scene appears stronger than usual. Edges and outlines may look sharper and more defined, and shadows deeper. It is commonly reported under psychedelics.
Cosmic significance Substance Search
Cosmic significance is the feeling that the present experience, or existence itself, carries immense meaning on a universal scale. Ordinary events may seem woven into a vast plan, or the person may feel they are witnessing or participating in something of ultimate importance, though the intensity of this feeling during intoxication is not evidence that any particular interpretation of it is accurate.
Cough suppression Dose.wiki
Cough suppression can be described as a decreased desire and need to cough. It is most commonly induced under the influence of moderate dosages of antitussive compounds such as, codeine, pholcodine, dextromethorphan, noscapine, and butamirate.
Craving Substance Search
Craving is an intense desire or urge to use a substance, often experienced as intrusive and difficult to ignore. It can be triggered by stress, reminders of past use, or the fading of a substance's effects, and it may persist long after other effects have ended.
Creativity enhancement Dose.wiki
Creativity enhancement is a perceived increase in one's capability to imagine new ideas, create art, or think about existing concepts in a novel manner. It is most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Creativity suppression Dose.wiki
Creativity suppression is a decrease in both a person's motivation and capabilities when performing tasks that involve producing artistic output or novel problem-solving. It is most commonly induced under the influence of moderate dosages of antipsychotics.
Crying Substance Search
Crying is the shedding of tears together with the physical behaviors of weeping, such as sobbing or a tightened throat. During substance experiences it may accompany sadness, but it is also commonly reported during moments of relief, awe, or emotional release, and it can sometimes occur with little identifiable feeling behind it.
Curiosity Substance Search
Curiosity is a heightened desire to explore, examine, and ask questions about one's surroundings, ideas, or sensations. Ordinary objects and topics can feel newly interesting and worth investigating, and attention is drawn toward whatever seems novel.
D
Decision-making impairment Substance Search
Decision-making impairment is a reduced ability to weigh options, judge risks, and think through the consequences of actions. A person experiencing it often does not feel impaired, and choices that would normally be rejected can seem reasonable in the moment.
Decreased arousal Substance Search
Decreased arousal is a lowered level of overall alertness and mental activation, felt as calmness, drowsiness, or a reduced drive to engage with what is happening. Reactions may slow, and the surroundings can feel less stimulating or interesting than usual. At stronger intensities it shades into outright sedation and sleepiness.
Decreased blood pressure Dose.wiki
Decreased blood pressure can be described as a condition in which the pressure in the systemic arteries is decreased to abnormal levels. It is most commonly induced under the influence of moderate dosages of GABAergic depressant compounds, such as benzodiazepines and barbiturates.
Decreased bodily temperature Substance Search
Decreased bodily temperature can be described as having a body temperature below one's normal baseline. It typically manifests as feeling cold, shivering, and cool or pale skin. It is commonly reported under sedating substances, and can be worsened in cold environments when a substance blunts the normal urge to warm up.
Decreased heart rate Dose.wiki
Decreased heart rate or bradycardia can be described as a heart rate that is lower than the normal heart rate at rest. It is most commonly induced under the influence of heavy dosages of depressant compounds, such as GABAergics, and opioids.
Decreased intracranial pressure Substance Search
Decreased intracranial pressure is a reduction in the pressure inside the skull. It is a physiological effect established by clinical measurement with certain anesthetics and sedatives rather than a sensation of its own, since pressure inside the skull cannot be felt precisely. When it appears in an effect list it reflects medical documentation, not something a person can reliably notice during an experience.
Decreased libido Dose.wiki
Decreased libido can be described as a distinct decrease in feelings of sexual desire, the anticipation of sexual activity, and the likelihood that a person will view the context of a given situation as sexual in nature. It is most commonly induced under the influence of moderate dosages of a wide variety of compounds, such as, opioids, antipsychotics and SSRI's, and dissociatives.
Decreased suicidal ideation Substance Search
Decreased suicidal ideation is a reduction in the frequency or intensity of thoughts about ending one's own life. It is a subjective, self-reported change described anecdotally during and after some drug experiences. A temporary shift of this kind is not evidence that any substance is a safe or effective treatment for suicidality.
Dehydration Dose.wiki
Dehydration can be described as an uncomfortably dry mouth and feelings of general thirstiness that results due to a lack of water intake. It is most commonly induced under the influence of moderate dosages of a wide variety of compounds such as, stimulants, psychedelics, opioids, dissociatives, deliriants, cannabinoids, alcohol, and antipsychotics.
Deja vu Dose.wiki
Déjà Vu or Deja Vu can be described as the sudden sensation that a current event or situation has already been experienced at some point in the past when, in actuality, it hasn't. It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and cannabinoids.
Delirium Dose.wiki
Delirium (also known as acute confusion) is medically recognized as a physiological disturbance of awareness that is accompanied by a change in baseline cognition which cannot be better explained by a preexisting or evolving neurocognitive disorder. The disturbance in awareness is manifested by a reduced ability to direct, focus, sustain, and shift attention and the accompanying cognitive change in at least one other area may include memory and learning (particularly recent memory), disorientation (particularly to time and place), alteration in language, or perceptual distortions or a perceptual-motor disturbance. It is most commonly induced under the influence of heavy dosages of deliriant compounds, such as DPH, datura, and benzydamine.
Delirium tremens Substance Search
Delirium tremens is a severe state of confusion, agitation, shaking, and hallucination that can develop when a person who has been drinking alcohol heavily for a long period suddenly stops or sharply cuts down. It may also involve fever, sweating, a racing heart, and disorientation about time and place. It is widely regarded as a medical emergency, which is one reason abrupt unassisted withdrawal from heavy alcohol use is considered especially risky.
Delusion Dose.wiki
A delusion is a false idea or belief that is held with strong conviction and subjective certainty and is inconsistent with an individual’s educational, cultural and social background. Delusions are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, deliriants, and dissociatives.
Delusions of sobriety Substance Search
Delusions of sobriety are false convictions that one is sober or unimpaired despite being clearly under the influence of a substance. They can lead a person to overestimate their abilities, for example believing themselves fit to drive or to take another dose, and are commonly reported under dissociatives, deliriants, and heavy doses of depressants.
Depersonalization Dose.wiki
Depersonalization is medically recognized as the experience of feeling detached from one's mental processes, body, or actions as if they are an outside observer. It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Depression Dose.wiki
Depression medically encompasses a large variety of different mood disorders whose common features are a sad, empty, or irritable mood co-occurring with bodily and cognitive changes that significantly disrupt an individual's ability to function. Within the context of psychoactive substance usage, depressivity is often accompanied by other coinciding effects such as anxiety, irritability and dysphoria.
Depression reduction Dose.wiki
Depression reduction is the experience of minimizing the symptoms associated with depression and low mood states. It most commonly occurs at varying levels of efficacy under the influence of a range of different substances, primarily psychedelics in combination with psychotherapy, or dissociatives.
Depth perception distortions Dose.wiki
Depth perception distortions are alterations in how a person perceives the distance of various objects within their visual field. They are most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Derealization Dose.wiki
Derealization or derealisation (sometimes abbreviated as DR) is the experience of feeling detached from, and as if one is an outside observer of, one's surroundings (e.g., individuals or objects are experienced as unreal, dreamlike, foggy, lifeless, or visually distorted). It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Dermatitis Substance Search
Dermatitis is inflammation of the skin, typically appearing as redness, itching, dryness, flaking, or a rash. In the context of substance use it can result from direct contact with an irritating material or from a broader reaction affecting the skin. It ranges from a mild, passing irritation to a persistent condition that interferes with comfort and sleep.
Diarrhea Dose.wiki
Diarrhea or diarrhoea is the condition of having at least three loose or liquid bowel movements each day. It is most commonly induced under the influence of heavy dosages of certain psychedelic compounds, such as ayahuasca, mescaline, and psilocybin mushrooms.
Difficulty breathing Substance Search
Difficulty breathing is the uncomfortable sensation of being unable to draw in enough air, or of breathing requiring noticeably more effort than usual. It can manifest as shortness of breath, tightness in the chest, or shallow and labored breaths. Persistent or worsening difficulty breathing is generally regarded as a serious warning sign rather than an ordinary side effect.
Difficulty integrating experiences Substance Search
Difficulty integrating experiences is trouble making sense of an intense or unusual experience after it has ended. The person may feel unable to reconcile what happened with their everyday life, beliefs, or sense of self, leaving lingering confusion, preoccupation, or unease. It is more often reported after experiences that were especially profound, frightening, or strange.
Difficulty urinating Dose.wiki
Difficulty urinating (also known as urinary retention) can be described as the experience of a decreased ability to pass urine. It is most commonly induced under the influence of heavy dosages of stimulant and opioid compounds, such as heroin, fentanyl, kratom, amphetamine, MDMA, and 4-FA.
Diffraction Dose.wiki
Diffraction is the experience of seeing rainbows and spectrums of colour embedded within the brighter parts of a person's visual field. It is most commonly induced under the influence of mild dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Digestive stimulation Substance Search
Digestive stimulation is an increase in the felt activity of the stomach and intestines, noticed as gurgling, churning, cramping, or a stronger urge to use the bathroom. It can also appear as a faster return of appetite after eating. Depending on its intensity it may pass unnoticed, feel mildly uncomfortable, or produce loose stools.
Disappointment Substance Search
Disappointment is the feeling of sadness or dissatisfaction that arises when an experience falls short of one's expectations or hopes. In substance contexts it is often reported when effects feel weaker, shorter, or different than anticipated, or during the return to baseline after a valued experience ends. It typically fades on its own as expectations adjust.
Disgust Substance Search
Disgust is a feeling of strong revulsion or aversion, as though something is offensive, contaminated, or deeply wrong. As a drug effect it can arise without any clear target, or attach itself to ordinarily neutral things such as food, smells, one's own body, or one's own thoughts.
Disinhibition Dose.wiki
Disinhibition is medically recognized as an orientation towards immediate gratification, leading to impulsive behavior driven by current thoughts, feelings, and external stimuli, without regard for past learning or consideration of future consequences. It is most commonly induced under the influence of moderate dosages of GABAergic depressants, such as alcohol, benzodiazepines, phenibut, and GHB.
Dissociation Substance Search
Dissociation is a sense of detachment or disconnection from one's body, emotions, or surroundings. It can range from mild dreaminess and numbness to a profound feeling that the world or the self is unreal, and it is the defining effect of the dissociative class of compounds.
Dissociative anesthesia Substance Search
Dissociative anesthesia is a state in which awareness of the body and its sensations, including pain, is strongly reduced or absent, while some form of inner consciousness may continue. The person can feel completely detached from their body and surroundings, and moving or communicating may become difficult or impossible. It is associated with heavy doses of dissociative compounds and carries physical risk, since injuries can go unnoticed and ordinary protective reflexes are dulled.
Dizziness Dose.wiki
Dizziness can be described as the perception of a spinning or swaying motion which typically causes a difficulty in standing or walking. It is most commonly induced under the influence of heavy dosages of GABAergic depressant compounds, such as benzodiazepines, alcohol, and GHB.
Dosage independent intensity Dose.wiki
Dosage independent intensity is the particularly rare and inconsistent experience of spontaneously amplified psychedelic effects that are extremely disproportionate to the dosage consumed. It is most commonly induced under the influence of mild dosages of psychedelic tryptamine compounds, such as ayahuasca, psilocybin, 4-AcO-DMT, and DMT.
Double vision Dose.wiki
Double vision is the experience of seeing duplicated vision, similar to when one crosses their eyes. This effect is most commonly induced under the influence of moderate dosages of depressant and dissociative compounds, such as alcohol, quetiapine, ketamine, and DXM.
Dream potentiation Dose.wiki
Dream potentiation is an effect that increases the subjective intensity, vividness, and frequency of sleeping dream states. It is most commonly induced under the influence of moderate dosages of oneirogenic compounds, a class of hallucinogen that is used to specifically potentiate dreams when taken before sleep.
Dream suppression Dose.wiki
Dream suppression is a decrease in the vividness, intensity, frequency, and recollection of a person's dreams. It is most commonly induced under the influence of moderate dosages of cannabinoids and most types of antidepressants.
Dream-like state Substance Search
A dream-like state is an experience in which waking consciousness takes on the qualities of a dream, such as loosened logic, drifting attention, and a sense of unreality or detachment from one's surroundings. Events during this state may feel hazy and disconnected, and can be difficult to remember afterward in the way dreams fade upon waking.
Drifting Dose.wiki
Drifting is the experience of the texture, shape, and general structure of objects and scenery appearing progressively warped, melted, and morphed across themselves. It is most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Dry eyes Substance Search
Dry eyes is a state in which the eyes are not kept adequately lubricated, resulting in sensations of grittiness, stinging, or irritation. It often occurs alongside other drying effects such as dry mouth, and is commonly reported under substances with antihistamine or anticholinergic properties.
Dry heaving Substance Search
Dry heaving is retching, the involuntary throat and stomach contractions of vomiting, without anything being brought up. It typically occurs when the stomach is already empty or when nausea continues after vomiting, and repeated episodes can leave the throat and abdominal muscles sore.
Dry mouth Dose.wiki
Dry mouth can be described as having a dry-feeling mouth often accompanied by a difficulty swallowing. It is usually a direct result of dehydration but can be felt to occur regardless of the actual dryness of a person's mouth. It is most commonly induced under the influence of moderate dosages of a wide variety of compounds, such as stimulants, psychedelics, opioids, antispychotics, deliriants, SSRI's, and cannabinoids.
Dulled perception Substance Search
Dulled perception is a decrease in the sharpness or intensity of one or more senses, such as vision, hearing, or touch. The world may feel muted, distant, or wrapped in a layer of numbness, and fine detail becomes harder to notice. It is commonly reported under dissociative and depressant compounds.
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Ego death Dose.wiki
Ego death (also known as ego suppression, ego loss or ego dissolution) is the temporary experience of a partial to complete disruption of a person's sense of self, which often results in a range of profound changes to how the person perceives and interprets their otherwise usually stable sense of identity, agency, and self-hood.
Ego fragmentation Substance Search
Ego fragmentation is the feeling that one's sense of self is splitting into separate parts rather than dissolving entirely. A person may seem to hold several viewpoints or selves at once, or feel their identity breaking into disconnected pieces that no longer add up to a single whole. It can be experienced as fascinating, disorienting, or intensely frightening depending on the person and setting.
Ego inflation Dose.wiki
Ego inflation is an effect that magnifies and enhances one's own ego and self-regard, resulting in the person feeling an increased sense of confidence, superiority, and general arrogance. It is most commonly induced under the influence of moderate dosages of stimulant compounds, particularly dopaminergic stimulants, such as methamphetamine and cocaine.
Ego replacement Dose.wiki
Ego replacement can be described as the sudden perception that one's sense of self and personality has been replaced with that of another person's, a fictional character's, an animal's, or an inanimate object's perspective. It is most commonly induced under the influence of moderate dosages of heavy dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.
Ego softening Substance Search
Ego softening is a partial loosening of a person's ordinary sense of self, in which the boundary between oneself and the outside world feels less rigid without disappearing entirely. It is often described as reduced self-consciousness or defensiveness, and is commonly reported at lower doses of psychedelic compounds; its more complete form is known as ego dissolution.
Embarrassment Substance Search
Embarrassment is a self-conscious feeling of awkwardness or shame about how one appears to others. During substance experiences it may arise from a perceived loss of composure, difficulty speaking, or a heightened awareness of one's own behavior, and anxiety can amplify it. The feeling often reflects the intoxicated person's self-perception more than how others actually see them.
Emotion intensification Dose.wiki
Emotion intensification is an increase in a person's current emotional state beyond normal levels of intensity. It is most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Emotion suppression Dose.wiki
Emotion suppression (also known as flat affect, apathy, or emotional blunting) is medically recognized as a flattening or decrease in the intensity of one's current emotional state below normal levels. It is most commonly induced under the influence of moderate dosages of antipsychotic compounds, such as quetiapine, haloperidol, and risperidone.
Emotional exhaustion Substance Search
Emotional exhaustion is the feeling of being emotionally drained or depleted, as if there is no energy left to feel or respond. Emotions may seem flattened, and ordinary interactions can require more effort than usual. It is commonly reported after intense emotional experiences and during comedowns.
Emotional lability Substance Search
Emotional lability is a state in which emotions shift rapidly and unpredictably, often with little relation to what is happening at the time. A person may move between laughter, tearfulness, irritability, and calm within a short period, and the swings can feel out of proportion or outside one's control. It is commonly reported during comedowns and withdrawal, and under a wide range of substances.
Emotional pain Substance Search
Emotional pain is a state of intense psychological suffering, such as grief, heartbreak, shame, or despair. It can feel as vivid and consuming as physical pain, and during emotionally amplified states buried feelings may surface unexpectedly, sometimes attached to memories or unresolved experiences.
Empathy, affection, and sociability enhancement Dose.wiki
Empathy, affection, and sociability enhancement is the experience of a mind state that is dominated by intense feelings of compassion, talkativeness, and happiness. It is most commonly induced under the influence of moderate dosages of entactogenic compounds, such as MDMA, 4-FA, and 2C-B.
Emptiness Substance Search
Emptiness is the felt absence of emotion, motivation, or meaning, often described as feeling hollow, numb, or blank inside. It is commonly reported during comedowns and in the days after intense or euphoric experiences, when ordinary feelings can seem temporarily out of reach.
Enhancement and suppression cycles Dose.wiki
Enhancement and suppression cycles is an effect which results in two opposite states of mind that do not occur simultaneously but instead swap between each other at seemingly random intervals. The first of these two alternate states can be described as the experience of cognitive enhancements which feel is if they drastically improve the person's ability to think clearly. The second of these two alternate states can be described as the experience of a range of cognitive suppressions which feel as if they drastically inhibit the person's ability to think clearly. They are most commonly induced under the influence of heavy dosages of psychedelic tryptamines, such as psilocybin, ayahuasca, and 4-AcO-DMT.
Enlightenment Substance Search
Enlightenment is the felt sense of having reached a profound or complete understanding of oneself, reality, or existence. It is sometimes reported during intense psychedelic or dissociative experiences, often alongside feelings of unity, awe, or loss of self-boundary. The feeling of profound understanding during intoxication does not guarantee that the understanding is accurate or will hold up afterward.
Environmental cubism Dose.wiki
Environmental cubism is a visual segmentation of the external environment into squares and cubes of varying amounts and sizes. It is most commonly induced under the influence of heavy dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Environmental orbism Substance Search
Environmental orbism is a visual effect in which translucent orb- or sphere-like shapes appear to float within or cover parts of the surrounding environment. The orbs are often described as luminous or bubble-like and may drift slowly across the visual field. It is an uncommonly reported effect, generally associated with higher doses of hallucinogens.
Environmental patterning Dose.wiki
Environmental patterning is the experience of certain textures or objects, such as carpets, clouds, and dense vegetation, drifting into increasingly complex geometric patterns that are clearly comprised of the original material they are manifesting from. It is most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Environmental transfiguration Substance Search
Environmental transfiguration is a visual effect in which one's surroundings appear transformed as a whole, taking on a changed character while their basic layout remains recognizable. A familiar room might look ancient, alien, sacred, or cartoon-like, as though the same place were being rendered in a different style. It is most commonly reported during strong psychedelic experiences.
Erection enhancement Substance Search
Erection enhancement can be described as an increase in the ease, firmness, or duration of erections relative to a person's normal baseline. It is reported anecdotally with some substances and contexts, and — as with other sexual effects — reports vary widely between individuals.
Euphoria Substance Search
Euphoria is an intense feeling of happiness, well-being, and contentment beyond what the situation alone would produce. It is often described as waves of physical and emotional pleasure, and is commonly reported under opioids, stimulants, and entactogens, though its character and strength vary widely between substances and individuals.
Excessive yawning Dose.wiki
Excessive yawning can be described as the experience of repeated, intensified, overly frequent, and spontaneous yawning despite a complete absence of genuine sedation or sleepiness. It is most commonly induced under the influence of moderate dosages of tryptamine psychedelic compounds, such as psilocybin, 4-AcO-DMT, 4-HO-MET, and ayahuasca.
Excitement Substance Search
Excitement is a feeling of heightened enthusiasm, anticipation, and mental energy. It is usually experienced as pleasant, though at high intensity it can shade into restlessness or a sense of being overstimulated.
Existential self-realization Dose.wiki
Existential self-realization can be described as a sudden realization, revelation, or reaffirmation of a person's existence within this universe. Existential self-realization is most commonly induced under the influence of moderate dosages of psychedelic and dissociative compounds such as ketamine, LSD, 4-AcO-DMT, and DCK.
External hallucination Dose.wiki
An external hallucination is the perception of a visual hallucination that displays itself seamlessly into the external environment as if it were physically present. They are most commonly induced under the influence of heavy dosages of deliriant compounds.
Eye pain Substance Search
Eye pain is an aching, burning, or pressure-like discomfort in or around the eyes. It may occur alongside light sensitivity, eye strain, or changes in pupil size, and it can make focusing on screens or bright environments unpleasant.
Eye rolling Substance Search
Eye rolling is an involuntary upward rolling of the eyes, sometimes accompanied by fluttering eyelids or difficulty holding a steady gaze. It usually occurs alongside other involuntary muscle effects and is commonly reported under entactogens such as MDMA and at heavy dosages of depressants.
Eye strain Substance Search
Eye strain is a feeling of tiredness, aching, or soreness in or around the eyes, sometimes accompanied by blurred vision or headache. As a drug effect it is often reported after long periods of staring or difficulty focusing, or when widened pupils let in more light than the eyes are comfortable with.
Eye twitching Substance Search
Eye twitching is an involuntary fluttering or repetitive movement of the eyelid or the muscles around the eye. It may also involve the eyes themselves making small jerky or wiggling movements that can make it harder to focus. It is commonly reported with stimulants and with fatigue.
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Fainting Substance Search
Fainting is a sudden, temporary loss of consciousness, most often caused by a brief reduction in blood flow to the brain. It is frequently preceded by lightheadedness, tunnel vision, sweating, or nausea, and consciousness typically returns within a short time once the person is lying flat. It is commonly reported in connection with sudden drops in blood pressure, such as standing up too quickly.
Fat redistribution Substance Search
Fat redistribution is a gradual change in where the body stores fat, rather than a change in overall weight alone. Over time, fat may shift between areas such as the abdomen, hips, thighs, face, and chest, subtly altering body shape. It is most often described in contexts involving sustained hormonal changes.
Fatigue Substance Search
Fatigue is a state of reduced physical and mental energy that makes activity and concentration feel more effortful than usual. Unlike ordinary sleepiness, it is not always relieved by rest. It is commonly reported during the offset or comedown of stimulating substances and as part of withdrawal or hangover states.
Fatigue suppression Substance Search
Fatigue suppression is a reduction or masking of tiredness, leaving a person feeling awake and capable despite a lack of rest. The underlying need for sleep is hidden rather than removed, and the suppressed fatigue tends to return strongly once the effect wears off. It is commonly associated with stimulants.
Feelings of impending doom Dose.wiki
Feelings of impending doom can be described as sudden sensations of overwhelming fear and urgency based upon the unfounded belief that a negative event is about to occur in the immediate future. They are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.
Fever reduction Substance Search
Fever reduction is a decrease in abnormally elevated body temperature back toward its normal range. It is typically noticed as the easing of fever symptoms such as sweating, chills, and general malaise.
Field of view alteration Dose.wiki
Field of view alteration is the experience of a perceived change in the open observable area a person can visibly see. It is most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Fish-eye distortion Substance Search
Fish-eye distortion is a visual effect in which the scene appears warped as if viewed through an ultra-wide lens, with the center of vision seeming to bulge forward and straight lines curving near the edges. The apparent size and distance of objects can shift along with the curvature. It is sometimes reported together with other perspective distortions.
Flatulence Substance Search
Flatulence is the passing of intestinal gas. As a drug effect it typically accompanies a temporarily unsettled digestive system and may occur alongside bloating, stomach gurgling, or mild cramping.
Fluid retention Substance Search
Fluid retention is the buildup of excess fluid in the body's tissues. It commonly appears as puffiness or swelling in the face, hands, ankles, or feet, a bloated feeling, or a rapid increase in body weight.
Focus enhancement Dose.wiki
Focus enhancement is the experience of an increased ability to selectively concentrate on an aspect of the environment while ignoring other things. It is most commonly induced under the influence of moderate dosages of stimulant and nootropic compounds, such as amphetamine, methylphenidate, modafinil, and caffeine.
Focus suppression Dose.wiki
Focus suppression is medically recognized as a decreased ability to selectively concentrate on an aspect of the environment while ignoring other things. It is most commonly induced under the influence of moderate or heavy dosages of antipsychotics, benzodiazepines, cannabinoids, and hallucinogens.
Foreshortening distortion Substance Search
Foreshortening distortion is a visual effect in which space appears compressed along the line of sight, making objects look closer, flatter, or shorter than they are. Hallways, rooms, and roads are common subjects, and the apparent depth of a scene may shift as one moves or refocuses. It is sometimes reported alongside other distortions of perspective and scale.
Frame rate suppression Dose.wiki
Frame rate suppression is the perceived reduction in speed at which visual information is processed. It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as ketamine, MXE, PCP, and DXM.
Frequent urination Dose.wiki
Frequent urination, or urinary frequency, can be defined as the need to urinate more often than usual. It is most commonly induced under the influence of moderate dosages of a wide variety of compounds, such as stimulants, psychedelics, dissociatives, and deliriants.
Frustration Substance Search
Frustration is a feeling of irritation and inner tension that arises when something feels blocked, stuck, or out of reach. During intoxication it can attach itself to small obstacles — a task that will not cooperate, a thought that will not complete — and feel disproportionately intense. It often eases once the triggering obstacle passes or the person's state shifts.
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Gait alteration Dose.wiki
Gait alteration is a change in the manner that a person walks and generally moves about throughout their environment. It is most commonly induced under the influence of moderate dosages of dissociatives such as ketamine, and especially DXM.
Gastrointestinal discomfort Substance Search
Gastrointestinal discomfort is an unpleasant sensation in the stomach or digestive tract, encompassing symptoms such as nausea, cramping, bloating, indigestion, and altered bowel habits. It can occur shortly after oral dosing, when a substance irritates the stomach directly, or later as a general bodily effect. It is commonly reported across many substance classes.
Genital sensitivity alteration Substance Search
Genital sensitivity alteration is a change in the physical sensitivity of the genitals, which can present as either an increase or a decrease in sensation. Decreased sensitivity may make arousal or orgasm difficult to achieve, while increased sensitivity can intensify sexual experiences. Both directions are reported, and the effect often occurs alongside broader changes in libido.
Geometry Dose.wiki
Geometry is the experience of a person's field of vision becoming partially or completely encompassed by fast-moving, colourful, and extremely complex geometric patterns, form constants, shapes, fractals, and colours.
Giddiness Substance Search
Giddiness is a light, bubbly excitement that often comes with an urge to laugh, talk, or be playful. Small things may seem unusually funny, and the mood can include a mildly floaty or lightheaded physical feeling. It typically arrives in bursts rather than as a steady state.
Glossolalia Dose.wiki
Glossolalia is an effect in which a person finds themselves involuntarily speaking and/or thinking in nonsensical speech which is structured in a manner that resembles an actual language. It is most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, deliriants, and dissociatives.
Goosebumps Substance Search
Goosebumps are small raised bumps on the skin caused by the involuntary contraction of tiny muscles at the base of body hairs. They typically appear in response to cold, strong emotion, or unusual tactile sensations, and are often reported alongside chills or waves of physical sensation.
Gratitude Substance Search
Gratitude is a heightened feeling of thankfulness and appreciation, directed toward specific people and circumstances or toward life in general. During substance experiences it can arise with unusual intensity, and it is often described as one of the longer-lasting emotional impressions an experience leaves behind.
Grief Substance Search
Grief is a deep sorrow felt in response to loss, most often the death of someone close, but also the loss of relationships, identities, or ways of life. During substance experiences, grief that is usually held at a distance can surface with unusual intensity, sometimes with crying, heaviness in the chest, or waves of emotion. This can feel overwhelming in the moment even when the underlying feeling is an ordinary response to loss.
Grogginess Substance Search
Grogginess is a state of sluggish, foggy alertness similar to being woken from deep sleep. It typically manifests as slowed thinking, heavy limbs, and difficulty becoming fully awake, and is commonly reported after sedatives or on waking from substance-affected sleep.
Guilt Substance Search
Guilt is a distressing emotion arising from the belief that one has done something wrong or failed to meet one's own moral standards. In the context of substance use it is often reported during comedowns and hangovers, where it may attach to the act of using itself, to behaviour during the experience, or to no clear cause at all.
Gustatory enhancement Dose.wiki
Gustatory enhancement is the experience of tastes becoming significantly richer, stronger, and more noticeable than that of everyday sobriety. It is most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline. However, it can also occur under the influence of cannabinoids and stimulants.
Gustatory hallucination Dose.wiki
A gustatory hallucination is any hallucination that involves one's sense of taste. A common example of this is a strong, unpleasant metallic taste in one's mouth. They are most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.
Gustatory suppression Dose.wiki
Gustatory suppression is the experience of tastes becoming significantly vaguer, weaker, and less noticeable than they would be during everyday sobriety. At higher levels, this can result in food becoming completely tasteless and significantly less appealing. It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.
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Hair loss Substance Search
Hair loss is thinning or shedding of hair beyond what is normal for the person. When reported in connection with substance use it tends to develop gradually over weeks to months of regular use rather than during a single experience, and it can also reflect the stress, poor sleep, or poor nutrition that sometimes surround heavy use.
Hallucinations Substance Search
Hallucinations are perceptions that occur without any corresponding external stimulus and can involve any of the senses, including sight, hearing, touch, smell, and taste. They vary from faint and clearly unreal to vivid and fully convincing. They are commonly reported under deliriants, at high doses of psychedelics and dissociatives, and during severe sleep deprivation.
Hallucinogen persisting perception disorder Substance Search
Hallucinogen persisting perception disorder (HPPD) is a condition in which visual disturbances that began during hallucinogen use — such as visual snow, afterimages, trails, or halos around objects — continue or recur long after the substance has left the body. Its severity varies widely, from subtle effects noticed only when looked for to persistent disturbances that interfere with daily life.
Haloing Substance Search
Haloing is a visual effect in which rings or glowing outlines of light appear around objects, especially bright ones such as lamps, screens, or the moon. The halos may be white or faintly colored and usually trace the shape of the object they surround. It is typically most noticeable in dim settings with strong points of light.
Head rush Substance Search
Head rush is a sudden, short-lived wave of lightheadedness, pressure, or tingling felt in the head. It can occur when standing up quickly or as a substance's effects first arrive, and depending on the context it may be experienced as pleasant, disorienting, or both at once.
Headache Dose.wiki
A headache can be described as a pain anywhere in the region of the head or neck. It can be a symptom of a number of different conditions. They are most commonly induced under the influence of heavy dosages of stimulating compounds, such as traditional stimulants, certain psychedelics, and certain dissociatives.
Heart palpitations Substance Search
Heart palpitations are an unusually strong awareness of one's own heartbeat, which may feel fast, pounding, irregular, or fluttering. They are commonly reported under stimulants and during states of anxiety, and even brief episodes can be frightening to notice.
Heart rate changes Substance Search
Heart rate changes are shifts in how fast the heart beats — either noticeably faster or noticeably slower than a person's usual resting rate. They may be felt as pounding, fluttering, or an unusual sense of stillness in the chest, or they may only be apparent when the pulse is checked. Many substances alter heart rate to some degree; large, sustained, or irregular changes are generally treated as a warning sign rather than a normal part of an experience.
Heightened awareness Substance Search
Heightened awareness is the feeling that the senses and attention have sharpened, so that more detail seems to be coming in than usual. Sounds, colors, textures, and small changes in the environment can feel unusually vivid or significant. The sense of perceiving more does not guarantee that perception or judgment is actually more accurate while intoxicated.
Hiccups Substance Search
Hiccups are repeated involuntary contractions of the diaphragm, each followed by a sudden closure of the vocal cords that produces the characteristic sound. Episodes are usually brief and harmless, though prolonged bouts can become uncomfortable.
Hopelessness Substance Search
Hopelessness is the feeling that one's situation cannot improve and that effort is pointless, often accompanied by low mood and a bleak view of the future. As a drug effect it is most often reported during comedowns, withdrawal, or difficult experiences, and it can feel absolute while it lasts even though the state itself is usually temporary.
Hot flashes Substance Search
Hot flashes are sudden, temporary waves of warmth typically felt most strongly in the face, neck, and chest. They may be accompanied by flushing of the skin, sweating, and a rapid heartbeat, and are sometimes followed by a chill as they pass.
Humility Substance Search
Humility is a felt reduction in self-importance, often with a sense of being one small part of something much larger, such as other people, nature, or the universe. It can be experienced as calm and grounding, or as sobering when it arrives suddenly. Some people describe it lingering as a changed outlook after the experience ends.
Hyperventilation Substance Search
Hyperventilation is a pattern of abnormally rapid or deep breathing that exceeds what the body currently needs. It can produce dizziness, tingling in the hands and around the mouth, and a feeling of panic, and it often occurs alongside intense anxiety.
Hypnagogic imagery Substance Search
Hypnagogic imagery is spontaneous imagery that appears behind closed eyes on the border between wakefulness and sleep, such as drifting patterns, faces, landscapes, or fragments of dream-like scenes. It occurs naturally as people fall asleep, but this borderline state can become easier to enter or more vivid in some drug-affected conditions. The imagery is usually recognized as internal rather than mistaken for the outside world.
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Identity alteration Dose.wiki
Identity alteration can be defined as the experience of one's sense of self becoming temporarily changed to feel as if it is comprised of different concepts than that which it previously did. This most commonly occurs during intense states of focus, meditation, or under the influence of hallucinogens such as psychedelics.
Illusion Substance Search
An illusion is a distorted perception of something that is really there — a real object, sound, or sensation that is seen, heard, or felt differently from how it actually is, such as a coat on a chair appearing to be a figure. It differs from a hallucination, in which a perception occurs with no external source at all. Illusions become more common in dim light, fatigue, and various intoxicated states.
Illusory clarity Substance Search
Illusory clarity is the compelling feeling that one's thinking has become unusually clear, ordered, or correct while intoxicated. The sense of clarity is itself the effect — it does not guarantee that the underlying thoughts are accurate, and ideas that feel obviously true in the moment may not hold up when sober.
Imagination enhancement Substance Search
Imagination enhancement is an increase in the vividness, detail, and spontaneity of mental imagery and fantasy. Daydreams and imagined scenes can feel unusually immersive and self-sustaining, often unfolding on their own behind closed eyes. Ideas conceived in this state can feel remarkably creative, though the felt brilliance of an idea during intoxication does not guarantee it holds up afterward.
Immersion enhancement Dose.wiki
Immersion enhancement is an effect that results in a pronounced increase in one's tendency to become fully captivated and engrossed by external stimuli, such as film, TV shows, video games, and various other forms of media. It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Increased blood pressure Dose.wiki
Increased blood pressure can be described as a condition in which the pressure in the systemic arteries is elevated to abnormal levels. It is most commonly induced under the influence of heavy dosages of deliriants and vasoconstricting compounds, such as traditional stimulants and stimulating psychedelics.
Increased bodily temperature Dose.wiki
Increased bodily temperature or pyrexia can be described as having a body temperature which is above normal baseline. It is most commonly induced under the influence of heavy dosages of stimulant compounds which affect serotonin and 5-HT receptors, dopamine and D receptors and norepinephrine.
Increased heart rate Dose.wiki
Increased heart rate or tachycardia is described as a heart rate that is faster than the normal heart rate at rest. It is most commonly induced under the influence of heavy dosages of stimulating compounds, such as traditional stimulants, certain psychedelics, and certain dissociatives.
Increased libido Dose.wiki
Increased libido can be described as a distinct increase in feelings of sexual desire, the anticipation of sexual activity, and the likelihood that a person will view the context of a given situation as sexual in nature. It is most commonly induced under the influence of moderate dosages of stimulant compounds, particularly dopaminergic stimulants such as methamphetamine and cocaine.
Increased music appreciation Dose.wiki
Increased music appreciation is a general sense of an increased enjoyment of music. It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and cannabinoids.
Increased pareidolia Dose.wiki
Increased pareidolia is an increase in a person's ability and tendency to recognise patterns (usually faces) within vague stimuli. It is most commonly induced under the influence of mild dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Increased perspiration Dose.wiki
Increased perspiration, or hyperhidrosis, can be described as a condition characterized by increased sweat which is in excess of that required for the regulation of body temperature. It is most commonly induced under the influence of stimulants, psychedelics, and benzodiapine or alcohol withdrawals.
Increased phlegm production Dose.wiki
Increased phlegm production can be described as the experience of the throat and respiratory system producing excessive amounts of mucous fluid that is often expelled via coughing. It is most commonly induced under the influence of heavy dosages of tryptamine psychedelic compounds, such as psilocybin, 5-MeO-MiPT, 4-AcO-DMT, and 4-HO-MET.
Increased salivation Dose.wiki
Increased salivation can be described as the production and excretion of excess saliva within the mouth, which may also be caused by decreased clearance of saliva. It is most commonly induced under the influence of heavy dosages of psychedelic tryptamine compounds, such as psilocybin, 4-AcO-DMT, and 4-HO-MET.
Increased sense of humor Dose.wiki
Increased sense of humor is as a general enhancement of the likelihood and degree to which a person finds stimuli to be humorous and amusing. It is most commonly induced under the influence of moderate dosages of certain hallucinogenic compounds, such as psychedelics, mescaline, and cannabinoids.
Increased suggestibility Dose.wiki
Increased suggestibility is a greater tendency to accept and act on the suggestions of others. It most commonly occurs under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, dissociatives, deliriants, and cannabinoids.
Increased thirst Substance Search
Increased thirst is the sensation of needing to drink more fluid than usual. It commonly accompanies dry mouth, and is commonly reported under stimulants as well as under substances with drying (anticholinergic) effects.
Increased vascularity Substance Search
Increased vascularity is a state in which veins near the surface of the skin become more visible or prominent. It is often noticed on the forearms, hands, and biceps, and tends to be more apparent when body fat or water retention is low.
Indigestion Substance Search
Indigestion is a feeling of discomfort or burning in the upper abdomen, typically arising during or after eating. It can manifest as bloating, nausea, belching, or a sense of uncomfortable fullness. It is commonly reported after the oral ingestion of substances that irritate the stomach.
Inflammation reduction Substance Search
Inflammation reduction is a decrease in the redness, swelling, heat, and pain that accompany the body's inflammatory response. It is typically experienced as relief from soreness, stiffness, or tenderness in affected areas.
Insight Substance Search
Insight is the felt experience of suddenly understanding something important, as though a problem, relationship, or aspect of one's life has snapped into focus. Realizations of this kind are commonly reported during psychedelic experiences and can feel unusually profound, though the feeling of insight during intoxication does not guarantee that the conclusion is accurate.
Insomnia Substance Search
Insomnia is difficulty falling asleep or staying asleep despite wanting and having the opportunity to rest. In the context of substance use it commonly occurs while a stimulating compound is still active in the body, and it can persist into the day or days following use.
Internal hallucination Dose.wiki
An internal hallucination is the perception of a visual hallucination that exclusively occurs within an imagined environment that can typically only be viewed with closed eyes, similar to those found within dreams. They are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.
Introspection Dose.wiki
Introspection can be described as the experience of a state of mind in which a person feels as if they are being encouraged or forced to reflect upon and examine aspects of their life, thoughts, and feelings. It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics and dissociatives.
Intrusive thoughts Substance Search
Intrusive thoughts are unwanted thoughts, images, or impulses that enter the mind involuntarily and can be difficult to dismiss. They are often repetitive, distressing, or out of character, and their content does not reflect the person's intentions. They occur in everyday life but are commonly reported in amplified form under hallucinogens and during stimulant comedowns.
Involuntary tongue movements Substance Search
Involuntary tongue movements are motions of the tongue that occur without the person intending them, such as writhing, pressing against the teeth or cheeks, or repetitive shifting inside the mouth. The person is often aware of the movement but finds it difficult to hold the tongue still. Prolonged episodes can leave the mouth, jaw, or tongue feeling sore or fatigued.
Irritability Dose.wiki
Irritability is medically recognized as the pervasive and sustained emotional state of being easily annoyed and provoked to anger. It is most commonly induced during the after effects of heavy dosages of stimulant compounds, such as cocaine, methamphetamine, and methylphenidate.
Itchiness Dose.wiki
Itchiness is the sensation that causes a person the desire or reflex to scratch at their skin. It is most commonly induced under the influence of heavy dosages of opioid compounds, such as heroin, fentanyl, tramadol, and kratom.
Itchiness suppression Substance Search
Itchiness suppression is a reduction in the intensity of itching sensations relative to what a person would ordinarily experience. It is typically noticed when skin irritation that would normally provoke scratching becomes faint or goes unnoticed. It is commonly reported under substances with antihistamine properties.
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Jamais vu Dose.wiki
Jamais vu can be described as the sudden sensation that a current event or situation is unfamiliar and being experienced for the very first time. It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and cannabinoids.
Jaw tremor Substance Search
Jaw tremor is an involuntary trembling or quivering of the jaw muscles, sometimes accompanied by chattering teeth or difficulty holding the mouth still. It is commonly reported alongside general muscle tension and teeth grinding, and it tends to ease as the overall effects subside.
Joint dryness Substance Search
Joint dryness is a sensation of stiffness, creaking, or aching in the joints, often attributed to reduced lubrication within them. It typically manifests as discomfort during movement or exercise that eases once the underlying cause resolves.
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Language distortion Substance Search
Language distortion is an altered experience of producing or understanding language. Words may become hard to find, sentences hard to hold together, or familiar words may suddenly sound strange, arbitrary, or loaded with unusual meaning. Reading and following conversation can take noticeably more effort while the effect lasts.
Language suppression Dose.wiki
Language suppression is the decreased ability to use and understand speech. It is most commonly induced under the influence of heavy dosages of antipsychotic compounds, such as quetiapine, haloperidol, and risperidone.
Laughter fits Dose.wiki
Laughter fits can be described as the experience of uncontrollable, intense, and spontaneous laughter which continue to occur despite a lack of any identifiable trigger or a feeling of humorousness. They are most commonly induced under the influence of moderate dosages of psychedelic and dissociative compounds, such as LSD, psilocybin, and nitrous oxide.
Libido fluctuation Substance Search
Libido fluctuation is a change in a person's level of sexual interest during an experience, which can move in either direction. Desire may feel heightened at some points and absent at others, and the direction can differ from one occasion to the next.
Lightheadedness Substance Search
Lightheadedness is a faint, woozy, or floaty feeling in the head, sometimes with a sense that one might pass out, especially when standing up. It often accompanies changes in blood pressure, dehydration, or sedation, and it typically eases when sitting or lying down.
Loneliness Substance Search
Loneliness is a distressing feeling of being isolated, disconnected, or cut off from others, regardless of whether one is actually alone. Under the influence of a substance it can feel unusually intense or all-encompassing. It is commonly reported during comedowns and withdrawal, and during difficult hallucinogen experiences.
Longing Substance Search
Longing is a persistent yearning or ache for something or someone absent, such as a person, a place, a past time, or an unnamed sense of completeness. It can surface with unusual intensity during emotionally amplified states and is often described as bittersweet rather than purely unpleasant.
Loss of consciousness Substance Search
Loss of consciousness is a state in which a person becomes unresponsive to their surroundings and to attempts to rouse them. Unlike ordinary sleep, a person in this state does not respond to voices, touch, or other stimulation. It is commonly reported at heavy dosages of depressant compounds and is generally regarded as a sign that emergency help is needed.
Low self-esteem Substance Search
Low self-esteem is a diminished sense of one's own worth, capability, or likability. During this state a person may dwell on perceived flaws or past failures and feel unusually self-critical or undeserving of positive regard. These judgments can feel convincing while the state lasts, but they reflect a temporary emotional shift rather than an accurate measure of the person.
Lung irritation Substance Search
Lung irritation is discomfort in the airways or chest, felt as burning, scratchiness, tightness, coughing, or wheezing. It is most commonly reported when material is smoked or vaporized, and harsher smoke or larger inhalations tend to make it worse. It can pass quickly or linger as a raw feeling and persistent cough after the session.
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Machinescapes Dose.wiki
Machinescapes are a complex visual and tactile experience where one perceives hallucinatory mechanical landscapes that are vast in both size and intricacy. They are most commonly induced under the influence of heavy dosages of salvia divinorum. However, they can also occur less commonly under the influence of psychedelic compounds, such as LSD, psilocybin, and 2C-P.
Magnification Dose.wiki
Magnification is the experience of distant details within one's visual field appearing magnified and closer than they actually are due to both visual enhancements and hallucinatory effects. It is a rare effect that is most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Malaise Substance Search
Malaise is a vague, general feeling of being unwell, run down, or simply off, without one specific symptom to point to. It often combines low energy, mild body discomfort, and a flat or uneasy mood, and it is commonly reported during comedowns and in the days following heavy use.
Mania Dose.wiki
Mania can be described as a state of abnormally elevated energy levels and general arousal. It is most commonly induced under the influence of heavy dosages of stimulant or dissociative compounds, such as methamphetamine, PCP, 2-Oxo-PCE, and cocaine.
Melancholy Substance Search
Melancholy is a quiet, lingering sadness or pensiveness, often without a single clear cause. During or after substance experiences it tends to appear as a subdued, reflective mood rather than acute distress. It commonly passes as the person returns to baseline.
Memory enhancement Dose.wiki
Memory enhancement is an improvement in a person's ability to recall or retain memories. It is most commonly induced under the influence of moderate dosages of stimulant and nootropic compounds, such as methylphenidate, caffeine, Noopept, nicotine, and modafinil.
Memory replays Dose.wiki
Memory replays are a multisensory subtype of internal hallucinations that result in a person reliving memories through the experience of vivid daydreams, reoccurring emotions or sensations, and hallucinations. They are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.
Memory suppression Dose.wiki
Memory suppression is an inhibition of a person's ability to maintain a functional short and long-term memory. It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.
Mental stimulation Substance Search
Mental stimulation is the experience of the mind feeling more energized and active than it does in everyday sobriety. Thoughts may arrive faster, feel easier to sustain, and carry a heightened urge to talk, plan, or work on tasks. At higher intensities the same effect can tip into racing or scattered thinking that is difficult to direct.
Meta-awareness of irrationality Substance Search
Meta-awareness of irrationality is the experience of noticing, while intoxicated, that one's own thoughts are not proceeding normally — observing confused, looping, or illogical thinking as it happens without being able to fully correct it. Some people find this observing perspective reassuring, while others find the gap between recognizing a thought as irrational and still experiencing it distressing.
Metallic taste Substance Search
A metallic taste is the perception of a metal-like flavour in the mouth that is not caused by anything actually eaten. It is often described as similar to the taste of copper or blood, and may appear shortly after dosing, particularly through routes where material can reach the back of the throat, such as insufflation. It is generally harmless in itself, though it can be unpleasant and persistent.
Mindfulness Dose.wiki
Mindfulness is the self-regulation of attention so that focus is directed towards immediate experience alongside of an orientation characterized by acceptance and a lack of judgement. It can occur under the influence of substances but is also practiced during meditation.
Mixed emotions Dose.wiki
Mixed emotions is the experience of feeling multiple emotions simultaneously without an obvious external trigger. They are most commonly induced under the influence of heavy dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Mixed stimulation and sedation Substance Search
Mixed stimulation and sedation is the experience of energizing and calming effects at the same time or in alternating waves. The body may feel heavy and relaxed while the mind races, or the reverse, and the balance can shift over the course of the experience. This push-pull quality feels smooth and functional to some people and confusing or unpleasant to others.
Mood elevation Substance Search
Mood elevation is a mild to moderate lift in mood — feeling brighter, lighter, or more positive than baseline. It is distinct from euphoria, which describes intense elation rather than a gentle improvement in emotional tone.
Mood stabilization Substance Search
Mood stabilization can be described as the experience of one's emotional state becoming steadier, with fewer or milder swings between highs and lows. It is typically noticed as an evenness of mood over time rather than as a distinct feeling of its own.
Motion exaggeration Substance Search
Motion exaggeration is a visual distortion in which movement appears larger, faster, or more dramatic than it actually is. Small gestures can seem sweeping and moving objects may appear to carry extra momentum, making the environment feel unusually animated.
Motivation enhancement Dose.wiki
Motivation enhancement is an increased desire to perform tasks and accomplish goals in a productive manner. It is most commonly induced under the influence of moderate dosages of stimulant and nootropic compounds, such as amphetamine, methylphenidate, nicotine, and modafinil.
Motivation suppression Dose.wiki
Motivation suppression (also known as avolition or amotivation) is a decreased desire to initiate or persist in goal-directed behavior. It is most commonly induced under the influence of an acute dosage of an antipsychotic compound, such as quetiapine, haloperidol, and risperidone. However, it is worth noting that chronic treatment with any dose of antipsychotic medication does not cause this effect.
Motor automatisms Substance Search
Motor automatisms are movements a person's body performs without a conscious decision to move, such as rocking, pacing, fidgeting, repeatedly touching objects, or small jaw and hand motions. The person is often unaware of the movement until their attention is drawn to it, and depending on the intensity of the experience the movement may or may not be possible to suppress.
Motor control loss Dose.wiki
Motor control loss can be described as feeling as if there has been a distinct decrease in a person's ability to control their physical body with precision, balance, coordination, and dexterity. Motor control loss is often accompanied by other coinciding effects such as sedation and disinhibition. It is most commonly induced under the influence of moderate dosages of GABAergic depressant compounds, such as, alcohol, benzodiazepines, GHB, and phenibut.
Mouth numbing Dose.wiki
Mouth numbing is a physical side effect of administering certain drugs sublingually (under the tongue) or buccally (via the cheeks and gum). The effect can be described as a distinct feeling of general numbness or tactile suppression around the tongue and mouth which can last for up to an hour after the drug has been administered.
Mouth pain Substance Search
Mouth pain is soreness or aching in the mouth, including the jaw, gums, tongue, or inner cheeks. As a drug effect it often follows jaw clenching, tooth grinding, or cheek chewing, and it can also result from dryness or irritation caused by smoked or orally held substances.
Multiple thought streams Dose.wiki
Multiple thought streams is a state of mind in which a person has more than one internal narrative or stream of consciousness simultaneously occurring within their head. They are most commonly induced under the influence of heavy dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Muscle cramp Dose.wiki
A muscle cramp can be described as an involuntary temporary contraction or over shortening of muscles which may cause severe aches and pains. They are most commonly induced under the influence of heavy dosages of stimulating psychedelic compounds, such as LSD, 2C-E, DOC, and AMT. However, they can also occur under the influence of certain GABAergic depressants such as GHB and phenibut.
Muscle pumps Substance Search
Muscle pumps are a sensation of fullness, tightness, and swelling in the muscles, usually most noticeable during or shortly after physical exertion. The affected muscles can look and feel larger and more engorged than usual. The feeling ranges from satisfying to painfully tight and cramp-like.
Muscle relaxation Dose.wiki
Muscle relaxation can be described as the experience of muscles losing their rigidity or tenseness while becoming relaxed and comfortable. It is most commonly induced under the influence of moderate dosages of depressant compounds, such as various benzodiazepines, GABAergics, and opioids.
Muscle soreness Substance Search
Muscle soreness can be described as aching, tenderness, or stiffness felt within the muscles. It is often noticed during the after-effects of an experience, particularly one that involved prolonged muscle tension, jaw clenching, or unusual physical activity.
Muscle spasms Substance Search
Muscle spasms are sudden, involuntary contractions of a muscle or group of muscles. They can range from brief, painless twitches to sustained and uncomfortable cramping, and may affect any part of the body. They are commonly reported under stimulants and during withdrawal from some depressants.
Muscle tension Dose.wiki
Muscle tension can be described as extended partial contractions or over shortening of muscles which can cause persistent low-level aches and pains. It is most commonly induced under the influence of heavy dosages of stimulating psychedelic compounds, such as LSD, 2C-E, DOC, and AMT.
Muscle twitching Dose.wiki
Muscle twitching can be described as the sensation of small and localised tremblings of muscle groups. These vibrations are often powerful enough to be visibly seen through the skin. It is most commonly induced under the influence of moderate dosages of stimulating psychedelic compounds such as LSD, 2C-E, DOC, and AMT.
Mystical experience Substance Search
A mystical experience is a profound alteration of consciousness commonly described as involving a sense of unity with the world, transcendence of time and space, deeply felt positive mood, and a conviction of encountering something significant, often alongside difficulty putting the experience into words. Such experiences are reported under high doses of psychedelics as well as in meditation, prayer, and other non-drug contexts.
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Nasal congestion Substance Search
Nasal congestion is a blocked or stuffy feeling in the nose caused by swollen nasal tissue and increased mucus. It is commonly reported after insufflation (snorting), and can also appear as a rebound effect when substances that constrict blood vessels in the nose wear off.
Nasal damage Substance Search
Nasal damage refers to physical injury to the tissues of the nose, including inflammation, sores, nosebleeds, and — in severe cases — erosion of the septum, the wall dividing the nostrils. It is associated with repeated insufflation (snorting) and is commonly reported to be worse with caustic or coarsely powdered material.
Nasal decongestion Substance Search
Nasal decongestion is a reduction of the swelling and mucus within the nasal passages, which makes it easier to breathe through the nose. It is commonly reported under compounds that narrow the blood vessels, such as many stimulants.
Nasal irritation Substance Search
Nasal irritation can be described as burning, stinging, or soreness in the nasal passages. It is commonly reported immediately after insufflating (snorting) a substance and typically fades as the material dissolves or drains, though repeated exposure can leave the passages persistently raw.
Nausea Dose.wiki
Nausea can be described as a sensation of unease and discomfort in the upper stomach combined with an involuntary urge to vomit. It is most commonly induced under the influence of heavy dosages of a wide variety of compounds, such as psychedelics, opioids, GABAergics, deliriants, dissociatives, and stimulants.
Nausea suppression Dose.wiki
Nausea suppression can be described as a reduction in vomiting, stomach cramps, and general feelings of nausea. It is most commonly induced under the influence of 5-HT3 receptor antagonists, cannabinoids, benzodiazepines, antihistamines, and others.
Near-death experience Substance Search
A near-death experience is a profound subjective event in which a person feels they have died or come close to dying, often featuring sensations of leaving the body, moving toward a light, reviewing one's life, or encountering other presences. Experiences with these features are reported at high doses of dissociatives and some psychedelics even when the person is not actually close to death, though such doses can still carry real physical risks of their own. They can be interpreted as deeply meaningful or deeply frightening, and their impact on a person's outlook may persist long afterward.
Neurotoxicity Substance Search
Neurotoxicity is damage to the structure or function of the nervous system caused by exposure to a substance. Depending on its extent, it can show up as problems with memory, mood, thinking, coordination, or sensation, and some of these changes may persist after use stops. How likely it is, and how severe, generally depends on the substance, the dose, and the pattern of use.
Nightmares Substance Search
Nightmares are vivid, disturbing dreams that cause fear or distress and often wake the sleeper. In the context of substance use they are commonly reported during withdrawal and during rebound sleep after substances that suppress dreaming, and they may be unusually intense, realistic, or recurrent compared to ordinary bad dreams.
Nodding Substance Search
Nodding is a semi-conscious state in which a person drifts back and forth between wakefulness and sleep. It typically manifests as the head slumping forward, the eyes closing, and speech trailing off, with the person briefly rousing before drifting off again. It is commonly reported under opioids and reflects a deep level of sedation.
Non-intoxicating Substance Search
Non-intoxicating is a term for substances or preparations that do not produce a noticeable high or altered mental state at the amounts typically used. The absence of a felt high does not mean an absence of effects — a non-intoxicating substance can still act on the body and still carry risks or interactions. The term describes the subjective experience, not overall safety.
Nosebleed Substance Search
A nosebleed is bleeding from the inside of the nose. In the context of substance use it is most often reported after insufflation (snorting), which can dry out and irritate the nasal lining. Frequent nosebleeds are generally taken as a sign that the nasal passages are irritated or damaged.
Nostalgia Substance Search
Nostalgia is a sentimental longing for, or wistful affection toward, one's own past. Under the influence of a substance it may manifest as vivid, emotionally charged recall of old memories, sometimes with an urge to revisit music, places, or people from earlier in life. The experience can feel pleasant, bittersweet, or melancholic depending on the memories involved.
Novelty enhancement Dose.wiki
Novelty enhancement is a feeling of increased fascination, awe, and appreciation attributed to specific parts or the entirety of one's external environment. It is most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
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Object activation Dose.wiki
Object activation is the experience of looking at an object and perceiving it to move, become alive, or become fully animated and autonomous of its own accord. It is most commonly induced under the influence of heavy dosages of deliriant compounds, such as DPH, datura, and benzydamine.
Object alteration Dose.wiki
An object alteration is the experience of perceiving objects and scenes to be progressively warping, moving, stretching, animating, and shifting in their 3-dimensional form. They are most commonly induced under the influence of heavy dosages of deliriant compounds, such as DPH and datura.
Obsessive thinking Substance Search
Obsessive thinking is a state in which a particular thought, worry, or idea repeats itself and is difficult to set aside. The mind may loop back to the same topic despite attempts to redirect attention, which can feel intrusive or distressing. It is sometimes reported under stimulants and during difficult psychedelic experiences.
Olfactory enhancement Dose.wiki
Olfactory enhancement (also known as hyperosmia) is the experience of smells becoming significantly richer, stronger, and more noticeable than they would be during everyday sobriety. This experience can either be positive or negative depending on the smell and the person's prior opinion of them. For example, while certain smells such as food or flowers may become a true delight during this experience, other smells such as pollution or body odour may become overpoweringly uncomfortable, which can potentially trigger nausea and vomiting.
Olfactory hallucination Dose.wiki
An olfactory hallucination (also known as phantosmia) is the detection or perception of a convincing imaginary smell that is not actually present in the person's environment. They are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as deliriants and psychedelics.
Olfactory suppression Dose.wiki
Olfactory suppression (also known as anosmia) is the experience of smells becoming significantly vaguer, weaker, and less noticeable than they would be during everyday sobriety. It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Optical sliding Dose.wiki
Optical sliding can be described as a physical effect which inhibits the coordination and control of a person's eyes by suppressing their ability to keep them still. It is most commonly induced under the influence of heavy dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Optimism Substance Search
Optimism is a felt expectation that things will turn out well, both in the immediate moment and in one's life more broadly. Problems that usually feel heavy may seem manageable, and future plans can take on a hopeful, energized quality. The brightened outlook may fade or persist to varying degrees after the experience ends.
Organic patterns Substance Search
Organic patterns are visual patterns with a living, natural quality, resembling vines, cells, scales, petals, or flowing biological forms rather than rigid geometry. They may appear overlaid on surfaces or within closed-eye visuals, and often seem to curl, grow, or breathe as they are watched. They are commonly reported under psychedelic compounds.
Orgasm enhancement Substance Search
Orgasm enhancement is an increase in the perceived intensity or pleasurability of orgasm compared with one's sober baseline. It is sometimes reported alongside broader enhancement of touch and physical sensation, though many substances have the opposite effect and individual responses vary widely.
Orgasm suppression Dose.wiki
Orgasm suppression (formally known as anorgasmia) can be described as a difficulty or complete inability to achieve orgasm despite adequate sexual stimulation. This effect commonly occurs on opioids and dissociatives which have been reported to decrease one's ability to feel sexual pleasure, which may be attributed to their tactile suppressing effects or through some other biological mechanism. It is also a well-known side effect of selective serotonin reuptake inhibitors (SSRIs).
Oscillation of existence Substance Search
Oscillation of existence is the sensation of one's sense of being flickering on and off, alternating between feeling that one exists and that one does not. It tends to accompany deep dissociative or ego-dissolving states and is often described as profoundly strange rather than straightforwardly pleasant or unpleasant. It is occasionally reported at heavy dosages of dissociatives and psychedelics.
Out-of-body experience Substance Search
An out-of-body experience is the sensation of perceiving the world, or one's own body, from a vantage point outside the physical body, such as feeling that one is floating above oneself. It is commonly reported at high doses of dissociative compounds and is generally considered a hallmark of deep dissociative states.
Overwhelm Substance Search
Overwhelm is the feeling that incoming sensations, emotions, or thoughts exceed one's capacity to take them in or respond. It can bring an urge to withdraw, shut down, or make the experience stop, and at higher intensities it may shade into panic. Many people report that it eases when stimulation is reduced, such as by moving to a quieter, calmer setting.
Overwhelming fear Substance Search
Overwhelming fear is an intense fear that dominates the experience and feels difficult or impossible to control. It may fix on a specific thought, such as dying or losing one's mind, or arrive with no clear object at all, and it is widely regarded as one of the most distressing effects a person can encounter.
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Pain Substance Search
Pain is an unpleasant physical sensation such as aching, burning, cramping, or stabbing that arises during or after a substance experience. It may be localized, for example in the head, stomach, muscles, or at a site of administration, or felt throughout the body. Unlike most subjective effects, new or severe pain generally functions as a warning signal from the body.
Pain enhancement Substance Search
Pain enhancement is an increase in the perceived intensity of physical pain or in one's awareness of it, so that discomfort which would ordinarily go unnoticed becomes prominent. Existing aches, injuries, or tension may feel amplified. It is sometimes reported under compounds that heighten bodily sensation generally.
Pain relief Dose.wiki
Pain relief can be described as an effect which suppresses negative sensations such as aches and pains. It is most commonly induced under the influence of moderate dosages of a very wide variety of compounds, such as opioids, GABAergics, GABApentinoids, cannabinoids, dissociatives, muscle relaxants, and NSAID's.
Panic attack Dose.wiki
A panic attack is a discrete period of sudden onset of intense fear or terror. During these attacks there are symptoms such as shortness of breath or smothering sensations; palpitations, pounding heart, or accelerated heart rate; chest pain or discomfort; choking; and fear of going crazy or losing control.
Panicked thinking Substance Search
Panicked thinking is a racing, fearful style of thought in which the mind fixates on worst-case interpretations and struggles to slow down or reason calmly. Thoughts may loop, jump to alarming conclusions, or feel impossible to interrupt, often alongside physical anxiety symptoms such as a pounding heart. The intense certainty that something is badly wrong does not necessarily reflect actual danger, and the state typically eases as the experience settles.
Paralysis Substance Search
Paralysis is a temporary inability to move part or all of the body despite trying to. It typically manifests as feeling locked in place or unable to lift the limbs, and it can be frightening when awareness remains intact. It is sometimes reported at heavy dosages of dissociatives and sedatives.
Paranoia Dose.wiki
Paranoia is the suspiciousness or the belief that one is being harassed, persecuted, or unfairly treated. It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as cannabinoids, psychedelics, dissociatives, and deliriants.
Parkinsonian symptom relief Substance Search
Parkinsonian symptom relief is a reduction in movement problems of the kind seen in Parkinson's disease, such as tremor, muscle rigidity, and slowness of movement. A person experiencing it may find that their hands are steadier, their movements smoother, or their walking easier for a period of time. The relief is typically temporary, lasting only while a substance's effects are active.
Pattern recognition suppression Substance Search
Pattern recognition suppression is a decreased ability to recognize and interpret familiar shapes, objects, faces, or symbols. Under its influence, ordinary things may look unfamiliar or take noticeably longer to identify, even though basic vision itself remains intact. It is commonly reported under dissociatives.
Perceived inanimate transformation Substance Search
Perceived inanimate transformation can be described as the experience of feeling that one's body has become, or is merging with, an inanimate object or material — for example stone, wood, machinery, or the surface one is resting on. It is felt as a change in body image rather than something seen. It is a rare effect occasionally reported under hallucinogens, particularly dissociatives.
Perceived temperature shift Substance Search
A perceived temperature shift is a change in how warm or cold the body feels that does not necessarily reflect actual body or room temperature. It can manifest as flushes of warmth, chills, or alternating waves of both, and is commonly reported under psychedelics and entactogens.
Perceived theriomorphosis Substance Search
Perceived theriomorphosis can be described as the experience of feeling that one's body has partly or fully taken on the form of a non-human animal. It is felt as a change in body image — for example, sensing paws, a tail, fur, or an altered posture — rather than something seen, though it may be accompanied by matching visual distortions. It is a rare effect occasionally reported under hallucinogens.
Perception of bodily heaviness Dose.wiki
Perception of bodily heaviness can be described as feeling as if one's body has significantly increased in its weight. This can result in feelings of slowness and sluggishness due to the body seeming difficult, uncomfortable, or impossible to move. It is most commonly induced under the influence of heavy dosages of depressant compounds, such as GABAergics, opioids, and antipsychotics.
Perception of bodily lightness Dose.wiki
Perception of bodily lightness can be described as feeling as if one's body has significantly decreased in its weight. This can result in feelings of increased energy and a general sense of bounciness due to the body seeming weightless and therefore effortless to move. It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Perception of eternalism Dose.wiki
Perception of eternalism can be described as the experience of a major alteration of one's perspective of the fundamental mechanics behind the linear continuity of time moving from the past, to the present, to the future. It is most commonly induced under the influence of heavy dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Perception of interdependent opposites Dose.wiki
Perception of interdependent opposites can be described as the experience of a powerful subjective feeling that reality is based upon a binary system in which the existence of fundamentally important concepts or situations logically arise from and depend upon the co-existence of their opposite. It is most commonly induced under the influence of heavy dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Perception of predeterminism Dose.wiki
Perception of predeterminism can be described as the sensation that all physical and mental processes are the result of prior causes, that every event and choice is an inevitable outcome that could not have happened differently, and that all of reality is a complex causal chain that can be traced back to the beginning of time. It is most commonly induced under the influence of heavy dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Perception of self-design Dose.wiki
Perception of self-design can be described as the experience of feeling that one is personally responsible for the creation, design, manifestation of a concept, process, or event which is normally seen as the result of unrelated external causes. It is most commonly induced under the influence of heavy dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Peripheral imagery Substance Search
Peripheral imagery is the appearance of fleeting shapes, movement, or figures at the edges of the visual field that vanish or resolve into ordinary objects when looked at directly. It is often experienced as the sense that something just moved out of view. It is reported across a range of substances as well as during fatigue and sleep deprivation.
Peripheral information misinterpretation Dose.wiki
Peripheral information misinterpretation is a fleeting experience of an object or detail within one's peripheral vision being interpreted and displayed incorrectly. It is most commonly induced under the influence of moderate dosages of deliriant compounds, such as DPH, datura, and benzydamine.
Peripheral stimulation Substance Search
Peripheral stimulation is stimulation felt mainly in the body rather than the mind, such as a racing heart, restlessness, jitteriness, or a persistent urge to move, without a matching increase in mental energy or focus. It is often described as uncomfortable because the body feels wired while the mind does not. It is commonly reported with some stimulating substances, especially at higher doses.
Personal bias suppression Dose.wiki
Personal bias suppression is a decrease in the cultural biases that a person filters their perception through. It is most commonly induced under the influence of hallucinogenic substances.
Personal meaning enhancement Dose.wiki
Personal meaning enhancement (also known as aberrant salience) is the experience of a considerably increased sense of personal significance becoming attributed to innocuous situations, and coincidences. It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics, dissociatives, cannabinoids, and deliriants.
Personality changes Substance Search
Personality changes are lasting shifts in a person's characteristic patterns of thinking, feeling, or behaving, as opposed to the temporary changes felt during an experience itself. They are sometimes reported after intense experiences or extended periods of use, and can be experienced as positive, such as greater openness, or as negative, such as increased irritability or flatness. Such changes are often noticed by the people around a person before the person notices them.
Personality regression Dose.wiki
Personality regression is a mental state in which one suddenly adopts an identical or similar personality, thought structure, mannerisms and behaviours to that of their past self from a younger age. It is a relatively rare effect that is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics, most notably Ayahuasca, LSD and Ibogaine in particular as well as certain dissociatives.
Perspective distortion Dose.wiki
A perspective distortion is a subtle to extreme change in how a person perceives the size and distance attributed to their body, specific parts of the external environment, or the external environment as a whole. They are most commonly induced under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, MXE, and DXM.
Perspective hallucination Dose.wiki
A perspective hallucination is an alteration of the perspective through which a given internal or external hallucination is seen through. They are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.
Perspective shifting Substance Search
Perspective shifting is the experience of viewing a situation, problem, or one's own life from an unfamiliar vantage point, as if stepping outside the usual way of seeing it. New framings can arrive spontaneously and often feel striking or meaningful, though the sense of insight felt during intoxication does not guarantee the new viewpoint is accurate. Some shifts fade with sobriety while others are remembered and reflected on afterward.
Philosophical thinking Substance Search
Philosophical thinking is an increased tendency to contemplate abstract questions about existence, meaning, consciousness, or one's place in the world. Ideas in these areas can feel unusually deep and significant while the state lasts, though the sense of profundity felt during intoxication does not guarantee the ideas hold up on sober reflection. It is commonly reported under psychedelics and dissociatives.
Photophobia Dose.wiki
Photophobia can be described as an abnormal physical intolerance to the visual perception of light. It is most commonly induced under the influence of heavy dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Photosensitivity Substance Search
Photosensitivity is an increased sensitivity to light. It can refer to the eyes, where ordinary levels of light feel uncomfortably bright or glaring, or to the skin, which reacts more strongly than usual to sunlight with redness or burning after relatively brief exposure. Either form is usually temporary but can make bright environments or time outdoors noticeably less comfortable.
Physical autonomy Dose.wiki
Physical autonomy can be described as the experience of a person's own body performing simple or complex actions entirely of its own accord. It is most commonly induced under the influence of heavy dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Physical disconnection Dose.wiki
Physical disconnection is the experience of feeling distant and detached from one's sense of touch and their feelings of ownership and control over their own physical body. This effect is most commonly induced under the influence of moderate dosages of depressant and dissociative compounds, such as, ketamine, PCP, and DXM.
Physical euphoria Dose.wiki
Physical euphoria can be described as feelings of pleasure and comfort within and across one's body. This euphoria typically feels somewhat comparable to the endorphin rushes felt during states of excitement or love, the coziness of a comfortable bed, and the rush of an orgasm. It is most commonly induced under the influence of heavy dosages of a wide variety of compounds, such as opioids, stimulants, psychedelics, and GABAergics.
Physical fatigue Dose.wiki
Physical fatigue can be described as a general feeling of bodily exhaustion. It is most commonly induced under the influence of moderate dosages of antipsychotic compounds, such as quetiapine, haloperidol, and risperidone. However, it can also occur during the withdrawal symptoms of many depressants, and during the offset of many stimulants.
Potentiation of other substances Substance Search
Potentiation of other substances is an effect in which one substance strengthens or prolongs the effects of another taken around the same time. The combined result can feel considerably stronger than either substance would produce on its own, which makes familiar doses behave unpredictably. It can apply to recreational and prescribed drugs alike.
Priapism Substance Search
Priapism is a prolonged and often painful erection that persists in the absence of sexual arousal or stimulation. An episode lasting more than a few hours is considered a medical emergency, as it can cause lasting tissue damage if left untreated.
Protracted comedown Substance Search
A protracted comedown is an offset phase that drags on much longer than expected, with residual effects lingering well after the main experience has ended. Common features include fatigue, low or flat mood, dulled thinking, and difficulty sleeping or feeling normal. It differs from an afterglow in that the lingering state is unpleasant rather than pleasant.
Psychosis Dose.wiki
Psychosis is as an abnormal condition of the mind and a general psychiatric term for a mental state in which one experiences a "loss of contact with reality." It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as deliriants, psychedelics, dissociatives, and cannabinoids.
Pupil constriction Dose.wiki
Pupil constriction (also called pinpoint pupils or miosis) can be described as the reduction of the size of a person's pupils under normal lighting conditions. It is most commonly induced under the influence of moderate dosages of opioid compounds, such as heroin, kratom, tramadol, and fentanyl.
Pupil dilation Dose.wiki
Pupil dilation can be described as the enlargement of the size of a person's pupils under normal lighting conditions. This is most commonly induced under the influence of moderate dosages of a wide variety of serotonergic compounds, such as psychedelics, dissociatives, deliriants, entactogens, various stimulants, and some antidepressants.
R
Rapid intoxication Substance Search
Rapid intoxication is the experience of a substance's effects arriving unusually quickly, so that the shift from feeling sober to feeling strongly affected happens over a very short span of time. Because there is little time to adjust, the transition can feel abrupt, intense, or overwhelming compared with a gradual onset. Faster onsets generally leave less room to gauge how strong the experience is becoming.
Rapid tolerance Substance Search
Rapid tolerance is a quick reduction in a substance's effects with repeated use over a short period, so that the same amount taken again soon afterward produces a noticeably weaker experience. With some substances this can develop within a single session or day and take days to weeks to fade. Taking larger amounts to compensate increases risk without reliably restoring the original effects.
Realistic hallucinations Substance Search
Realistic hallucinations are perceptions of objects, people, scenes, or events that are not actually present but look and feel indistinguishable from ordinary reality. Unlike patterned or obviously dreamlike imagery, they copy the texture, lighting, and logic of the real environment, and the person may not recognize them as hallucinations while they are happening. This loss of the ability to tell perception from reality can make the experience deeply disorienting.
Rebirth Substance Search
Rebirth is the felt experience of an old self ending and a new one beginning, often described as dying and being born again within a single experience. It is commonly reported during intense psychedelic and dissociative experiences and can be accompanied by strong emotions ranging from terror to relief. The sense of profound personal transformation felt in the moment does not always persist once the experience ends.
Rebound insomnia Substance Search
Rebound insomnia is difficulty falling or staying asleep that emerges when a substance which had been promoting sleep wears off or is discontinued. Sleep during this period is often lighter and more fragmented than it was before the substance was used. It is commonly reported after regular use of sedating substances comes to an end.
Recursion Dose.wiki
Recursion is a visual distortion that alters the appearance of one's external environment by repeating specific sections of itself across itself in a self-similar fashion. It is most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Red eyes Substance Search
Red eyes are a visible reddening of the whites of the eyes caused by widening of the small blood vessels on their surface. The effect is painless in itself, though it may occur alongside dryness or irritation, and it is one of the more outwardly noticeable signs of recent use. It is commonly reported under cannabis and other cannabinoids.
Reduced blood clotting Substance Search
Reduced blood clotting is a decreased ability of the blood to form clots, so that bleeding takes longer to stop. It is usually not felt directly, but can show up as easy bruising, nosebleeds, bleeding gums, or small cuts that keep oozing. It becomes more significant when injuries occur or when combined with other things that also thin the blood.
Reduced hyperactivity Substance Search
Reduced hyperactivity is a decrease in excess physical restlessness and the constant urge to move. Sitting still, staying with one task, and moving at a deliberate pace all become easier, and fidgeting tends to drop away. It is usually experienced as calming rather than sedating, though the line between the two can blur at higher intensities.
Reduced impulsivity Substance Search
Reduced impulsivity is a lessened tendency to act on urges the moment they appear. There is a felt widening of the gap between wanting to do something and doing it, leaving more room to weigh consequences first. People often notice it indirectly, as fewer interruptions, snap decisions, or unplanned actions, rather than as a distinct sensation.
Reduced water retention Substance Search
Reduced water retention is a decrease in the amount of water held in the body's tissues. It may be noticed as a leaner or more defined physical appearance, looser rings or clothing, and more frequent urination.
Regret Substance Search
Regret is the unpleasant feeling of wishing one had acted differently, directed at a past choice or event. During or after substance experiences it may attach to the decision to take the substance, to things said or done while intoxicated, or to older memories brought into sharp focus. It is commonly reported during comedowns and often softens as mood returns to baseline.
Rejuvenation Dose.wiki
Rejuvenation can be described as feelings of mild to extreme cognitive refreshment which are felt during the afterglow of certain compounds. It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics and dissociatives.
Relaxation Substance Search
Relaxation is a decrease in physical and mental tension, leaving the muscles feeling looser and the mind more at ease. It often appears as a reduced urge to move about, a slower pace of thought, and a general sense of comfort. It is commonly reported under depressants and cannabinoids.
Relief Substance Search
Relief is the easing of a distressing feeling or physical discomfort, often experienced as a release of built-up tension. It is defined by contrast: the pleasantness comes from something unpleasant — pain, anxiety, craving, dread — loosening its grip. It may arrive as a sudden wash of ease or as a gradual settling.
Religious imagery Substance Search
Religious imagery is the appearance of spiritual or religious content within visual effects, such as deities, angels, temples, mandalas, or symbols of faith. It is commonly reported during intense psychedelic experiences and can occur regardless of the person's own beliefs, sometimes carrying a strong sense of significance in the moment.
Resentment Substance Search
Resentment is a lingering feeling of bitterness or grievance toward a person or situation perceived as having caused unfair harm. During emotionally intense experiences, old grievances may resurface with renewed force, sometimes over events long past.
Respiratory depression Dose.wiki
Respiratory depression can be described as a reduced urge to breathe that can be fatal depending on its intensity. It is most commonly induced under the influence of heavy dosages of depressant compounds, particularly opioids, such as heroin and fentanyl, or GABAergics, such as alcohol and GHB. However, it is worth noting that otherwise safe dosages of these compounds can become fatal when combined with even small amounts of other classes of depressant.
Restless legs Dose.wiki
Restless legs (also known as restless legs syndrome or RLS) is a neurological disorder characterized by an irresistible urge to move one's body to stop uncomfortable or odd sensations. Restless legs syndrome is most commonly induced during the withdrawal symptoms of many depressants, such as opioids or benzodiazepines, and during the offset of many stimulants, such as methamphetamine, cocaine, and MDMA. However, it can also occur under the influence of deliriants such as DPH and datura.
Restlessness Substance Search
Restlessness is an uncomfortable inability to remain still or at ease, often expressed as fidgeting, pacing, or a persistent urge to move. It is commonly reported under stimulating compounds and can also appear during withdrawal from depressants.
Reverence Substance Search
Reverence is a feeling of deep respect, awe, or veneration directed toward something experienced as larger than oneself, such as nature, existence, another person, or the experience itself. It is commonly reported during psychedelic experiences and can feel sacred or worshipful even in people who do not consider themselves religious.
Rhabdomyolysis Substance Search
Rhabdomyolysis is a serious medical condition in which muscle tissue breaks down and releases its contents into the bloodstream, where they can damage the kidneys. Commonly reported warning signs include severe muscle pain or weakness and unusually dark, tea-coloured urine. Recognised contributors include prolonged overexertion, overheating, and immobility, such as dancing for hours in a hot environment or remaining collapsed in one position.
Rhythmic perception enhancement Substance Search
Rhythmic perception enhancement is an increased awareness of and engagement with rhythm, most noticeable while listening or moving to music. Beats can feel more distinct, compelling, or physically felt, and the urge to dance or move in time may grow stronger. It is commonly reported with stimulating and entactogenic substances.
Rippling Substance Search
Rippling is a visual effect in which surfaces such as walls, floors, water, or skin appear to move in gentle waves, as if their texture were flowing. The object itself is usually still understood to be stationary while its surface undulates. It is commonly reported under psychedelic compounds.
Runny nose Dose.wiki
A runny nose can be described as a condition where the nasal cavity is filled with a significant amount of mucous fluid, otherwise known as "snot". It is most commonly induced under the influence of heavy dosages of tryptamine psychedelic compounds, such as psilocybin, 4-AcO-DMT, and 4-HO-MET. However, it can also occur under the influence of opioid withdrawals) and as a symptom of cocaine abuse.
Rush Substance Search
Rush is a sudden surge of intense sensation, often described as warmth, pressure, euphoria, or physical energy, arriving in the first moments after a substance takes effect. It is most commonly described when onset is rapid, and it generally gives way to the more stable body of the experience as onset completes.
S
Sadness Substance Search
Sadness is a state of low mood characterized by feelings of sorrow, loss, or emotional heaviness. During substance experiences it may surface without an obvious trigger, or previously buried feelings may rise with unusual force. It is also commonly reported during comedowns and withdrawal.
Scenarios and plots Dose.wiki
Scenarios and plots are the situations, stories, and events that occur within both external and internal hallucinations. They are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.
Scene replacement Substance Search
Scene replacement is a hallucinatory effect in which a person's view of their surroundings is partially or fully replaced by a different, self-contained scene or environment. The new scenery can feel as detailed and convincing as ordinary sight before shifting or dissolving back into the real environment. It is generally described at the more intense end of hallucinatory experiences.
Scenery slicing Dose.wiki
Scenery slicing is the experience of a person's visual field appearing to split into separate, cleanly cut sections. These individual slices then proceed to drift slowly away from their original position before disappearing and resetting to normal. It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Sedation Dose.wiki
Sedation can be described as a decrease in a person's physical energy levels which are interpreted as discouraging when it comes to wakefulness, movement, performing tasks, talkativeness, and general exercise. It is most commonly induced under the influence of moderate dosages of depressant compounds, such as opioids, GABAergics, and antipsychotics.
Seizure Dose.wiki
An epileptic seizure (colloquially a fit) can be described as a brief episode of signs and/or symptoms which are due to abnormal, excessive, or synchronous neuronal activity in the brain. They are most commonly induced under the influence of withdrawals from prolonged chronic benzodiazepine or alcohol usage.
Seizure suppression Dose.wiki
Seizure suppression is an effect caused by drugs known as "anticonvulsants". These drugs prevent or reduce the severity and frequency of seizures in various types of epilepsy. It is most commonly induced under the influence of moderate dosages of certain GABAergic compounds and certain cannabinoids.
Selective auditory attention Substance Search
Selective auditory attention is a change in how hearing is focused, in which certain sounds seem amplified and singled out while others fade into the background. A single conversation, instrument, or background noise may capture attention completely, making it harder to follow everything at once. It is sometimes reported under psychedelics and cannabis.
Self-hatred Substance Search
Self-hatred is an intense turning of negative feeling against oneself, with harsh self-criticism, shame, or disgust aimed at one's own character, body, or past actions. These feelings can surface with unusual force during intoxication or comedowns, and their intensity in the moment is not a reliable measure of their accuracy. It is generally experienced as one of the more painful emotional effects.
Self-multiplication Substance Search
Self-multiplication is the experience of feeling as though one has split into, or exists as, more than one simultaneous copy of oneself. Those who report it often describe their awareness as divided across several bodies or points of view at the same time. It is a rare effect most commonly reported under hallucinogens.
Sensed presence Dose.wiki
A sensed presence is the distinctive feeling that another conscious agent is present alongside one's own self. It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.
Sensory enhancement Substance Search
Sensory enhancement is an overall intensification of one or more of the senses. Sights, sounds, tastes, smells, and physical sensations may all feel more vivid, detailed, or engaging than they normally would.
Sensory overload Dose.wiki
Sensory overload within the context of psychoactive substance usage is the experience of feeling overwhelmed by the sheer amount of sensory inputs occurring as a result of various other subjective effects. It is most commonly induced under the influence of heavy dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Settings, sceneries, and landscapes Dose.wiki
Settings, sceneries, and landscapes are the perceived environments in which the plot of an internal or external hallucination occurs. This effect is capable of manifesting in a seemingly infinite variety of potential places and settings. They are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.
Sexual dysfunction Substance Search
Sexual dysfunction is a reduction in the ability to engage in or enjoy sexual activity, which can involve lowered desire, difficulty becoming aroused, erectile difficulties, or an inability to reach orgasm. It may occur acutely during a substance's effects or in association with longer-term use. It is commonly reported under stimulants, opioids, and many antidepressants.
Sexual imagery Substance Search
Sexual imagery is the appearance of erotic content in closed- or open-eye visuals, dreams, or spontaneous mental imagery. It can range from suggestive shapes and themes to explicit scenes, and it may occur whether or not the person feels aroused or welcomes the content.
Shadow people Dose.wiki
Shadow people are the experience of perceiving patches of shadow in one's peripheral or direct line of sight to appear and behave as living, autonomous beings. They are most commonly induced under the influence of heavy dosages of deliriant compounds, such as DPH, datura, and benzydamine.
Shakiness Dose.wiki
Shakiness is the experience of vibrations and trembling throughout a person's body, their limbs, or most commonly, their hands. It is most commonly induced under the influence of moderate dosages of stimulating psychedelic compounds.
Shame Substance Search
Shame is a painful emotional state centered on the feeling of being flawed, exposed, or judged negatively, often accompanied by an urge to hide or withdraw. In the context of substance use it is sometimes reported during comedowns or afterward, when a person reflects on their behavior while intoxicated. It differs from guilt in that it tends to target the whole self rather than a specific action.
Shimmering Substance Search
Shimmering is a visual effect in which surfaces and edges appear to waver, sparkle, or ripple with light, similar to heat haze rising from a road or sunlight on water. It typically affects textured or brightly lit areas first and is commonly reported at lighter intensities of psychedelic experiences.
Size distortion Substance Search
Size distortion is a visual effect in which objects appear larger or smaller than they actually are. It can affect a single object or the entire scene, and may make familiar spaces feel unusually vast or cramped. It is commonly reported under psychedelics and dissociatives.
Skin flushing Dose.wiki
Skin flushing can be described as the experience of a sudden reddening of the skin which is usually accompanied by feelings of rushing blood and warm skin. It is most commonly induced under the influence of heavy dosages of opioid compounds, such as heroin, tramadol, fentanyl, and kratom. However, it can also occur under the influence of alcohol, certain psychedelics such as 5-MeO-DMT, and stimulants, such as caffeine.
Skin softening Substance Search
Skin softening is a perceived increase in the smoothness and softness of the skin. It may be experienced as a genuine change in the skin's texture or as a change in tactile perception in which the skin simply feels softer to the touch than usual. It is an infrequently reported effect and is not generally considered harmful.
Sleep deprivation Substance Search
Sleep deprivation is the state that results from getting too little sleep, whether because a substance prevents sleep or because use has displaced it. It typically brings grogginess, poor concentration, slowed reactions, and irritability, and when extended over long periods it can produce perceptual disturbances and confusion.
Sleep disruption Substance Search
Sleep disruption is a reduction in the quality, depth, or continuity of sleep, even when falling asleep remains possible. It can involve frequent waking, restless or shallow sleep, unusually vivid or unpleasant dreams, and feeling unrefreshed the next day, and it is commonly reported in the hours or days after using stimulating compounds.
Sleep disturbance Substance Search
Sleep disturbance is a reduced ability to fall asleep or stay asleep, or a reduction in the quality of sleep itself. It can manifest as lying awake for long periods, waking frequently during the night, restless or unrefreshing sleep, or unusually vivid and unpleasant dreams. It is commonly reported during and after the use of stimulating compounds.
Sleep enhancement Substance Search
Sleep enhancement is an increased ability to fall asleep and stay asleep. It typically manifests as feeling drowsy at bedtime, falling asleep more quickly than usual, or experiencing what feels like deeper or longer sleep, and is commonly reported under sedating compounds. The perceived depth of such sleep does not necessarily reflect how restful it actually is.
Sleep paralysis Substance Search
Sleep paralysis is a temporary inability to move or speak that occurs while falling asleep or waking up, during which the person remains aware of their surroundings. Episodes often include a sensation of pressure on the chest and can be accompanied by vivid, frightening hallucinations such as a sensed presence in the room. Episodes typically resolve on their own within seconds to minutes.
Sleepiness Dose.wiki
Sleepiness (also known as drowsiness) is medically recognized as a state of near-sleep, or a strong desire for sleep without feeling a decrease in one's physical energy levels. This state is independent of a circadian rhythm; so, unlike sedation, this effect does not necessarily decrease physical energy levels but instead decreases wakefulness. It is most commonly induced under the influence of moderate dosages of a wide variety of compounds such as cannabinoids, GABAergic depressants, opioids, antipsychotics, some antihistamines, and certain psychedelics.
Sleepwalking Substance Search
Sleepwalking is the performance of actions such as walking, talking, eating, or more complex behavior while not fully awake, typically with little or no memory of it afterward. As a drug effect it is most often reported with sedating substances taken around bedtime, and it carries risk because the person is acting without awareness of their surroundings.
Slurred speech Substance Search
Slurred speech is a reduction in the clarity and articulation of spoken words, causing them to run together or sound mumbled. It results from impaired coordination of the muscles used in speaking and typically appears alongside other signs of motor impairment. It is commonly reported under depressants such as alcohol and benzodiazepines.
Sociability suppression Substance Search
Sociability suppression is a decreased desire or ability to engage in social interaction. Conversation may feel effortful or unappealing, and a person may withdraw even in familiar company. It can accompany strongly introspective states as well as comedowns from stimulating compounds.
Sound layering Substance Search
Sound layering is the experience of hearing a piece of audio as a set of distinct, separated layers rather than a single blended whole. In music this often means individual instruments, voices, or effects seem to stand apart from one another and can be followed independently. Ambient environments can show the same separation, with background noises becoming individually noticeable.
Spatial disorientation Dose.wiki
Spatial disorientation is the failure to perceive or perceiving incorrectly the position, motion, or altitude of oneself within the fixed coordinate system provided by the surface of the Earth and the gravitational vertical. It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as diphenidine, ketamine, and DXM.
Speech distortion Substance Search
Speech distortion is a reduced ability to produce clear and fluent speech. Words may come out slurred, jumbled, repeated, or in the wrong order, and the person may notice a gap between what they intend to say and what they actually say. Others may find the person hard to understand even when their inner train of thought feels coherent to them.
Spirituality enhancement Dose.wiki
Spirituality enhancement can be described as the experience of a shift in a person’s personal beliefs regarding their existence and place within the universe, their relationship to others, and what they value as meaningful in life. It is most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Spontaneous physical movements Dose.wiki
Spontaneous physical movements are the experience of seemingly random yet structured movements or twitches in groups of muscles throughout the body. They most commonly occur under the influence of heavy dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Spontaneous tactile sensations Dose.wiki
Spontaneous tactile sensations are the experience of sensations across the body occurring without any obvious or immediate physical trigger. This results in feelings of seemingly random yet distinct tingling sensations that occur across the skin and within the body. Depending on the psychoactive substance consumed, these vary greatly in their styles of sensation.
Stamina enhancement Dose.wiki
Stamina enhancement can be described as an increased ability to engage in physically and mentally taxing activities without the development of fatigue. It most commonly occurs under the influence of stimulants such as amphetamine and specific psychedelics such as LSD.
Stimulation Dose.wiki
Stimulation can be described as an increase in a person's physical energy levels. It is most commonly induced under the influence of stimulant compounds, such as amphetamine, MDMA, and cocaine.
Stomach bloating Dose.wiki
Stomach bloating can be described as an uncomfortable physical side effect which results in one's stomach becoming temporarily bloated and expanded in a manner which looks somewhat similar to pregnancy. It is most commonly induced under the influence of heavy dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline. However, it can also occur under the influence of stimulants, opioids, and depressants.
Stomach cramp Dose.wiki
A stomach cramp can be described as an intense feeling of sudden pain or discomfort which occurs within the stomach. They are most commonly induced under the influence of heavy dosages of a wide variety of compounds, such as psychedelics, opioids, GABAergics, and deliriants.
Stomach discomfort Substance Search
Stomach discomfort can be described as an unpleasant sensation felt in the stomach or upper abdomen. It commonly manifests as feelings of unease, cramping, bloating, or mild nausea, and is frequently reported after a substance is swallowed, particularly on an empty stomach.
Stoned feeling Substance Search
Stoned feeling is a heavy, relaxed state in which the body feels weighted down and the mind becomes slow, dreamy, and easily absorbed in whatever is in front of it. It is most often described in connection with cannabis and other cannabinoids, though similar states are reported with a range of depressants. Many people find it pleasant and calming, while others experience it as foggy, dull, or demotivating.
Strength increase Substance Search
Strength increase is the experience of being able to exert more physical force than usual, whether during exercise, lifting, or everyday movement. It may reflect a genuine change in performance, a blunting of fatigue and discomfort, or simply the perception of greater power. Felt strength during intoxication does not always match actual capacity, which can invite overexertion or strain.
Subconscious communication Substance Search
Subconscious communication is the experience of receiving thoughts, images, or messages that feel as though they come from a deeper part of one's own mind rather than from deliberate thinking, sometimes taking the form of an inner voice or dialogue. The material can feel personally meaningful, though the sense that it comes from a wiser or hidden source does not make its content more reliable than ordinary thought.
Sudden sleep onset Substance Search
Sudden sleep onset is an abrupt, sometimes irresistible transition into sleep with little or no warning drowsiness beforehand. A person may nod off mid-activity or mid-conversation and be unaware it happened until they wake. It is a particular hazard around driving, machinery, water, and other situations where a lapse in consciousness can cause injury.
Suggestibility suppression Dose.wiki
Suggestibility suppression is a decreased tendency to accept and act on the suggestions of others. It is most commonly induced under the influence of GABAergic depressants.
Suicidal ideation Dose.wiki
Suicidal ideation can be described as the experience of compulsive suicidal thoughts and a general desire to end one's own life. It is most commonly induced under the influence of moderate dosages of various antidepressants of the selective serotonin reuptake inhibitor class.
Surreality Substance Search
Surreality is the feeling that one's surroundings or experience have become dreamlike, strange, or subtly "off," even when nothing specific has visibly changed. Familiar places and situations can feel improbable or staged, as if the ordinary rules of the world have loosened. The feeling can be experienced as fascinating, amusing, or unsettling, and it typically fades as the experience wears off.
Symbolic imagery Substance Search
Symbolic imagery is the experience of visions or mental images that feel charged with meaning, such as archetypal figures, cultural or religious symbols, or personally significant scenes. It is most often described with the eyes closed during more intense experiences, and the felt sense that an image carries a message is part of the experience rather than evidence of one.
Symmetrical texture repetition Dose.wiki
Symmetrical texture repetition is the perception of textures becoming mirrored repeatedly over their own surface in an intricate and symmetrical fashion that is consistent across itself. It is most commonly induced under the influence of mild dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Synaesthesia Dose.wiki
Synaesthesia (also spelt synesthesia or synæsthesia) is the experience of a blending, merging, or mixing of the senses. Synaesthesia is commonly induced under the influence of heavy dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
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Tactile distortion Dose.wiki
A tactile distortion is the experience of a perceived alteration in one's sense of touch. This is distinct from that of a tactile hallucination, as it exclusively alters the perception of pre-existing sensations and does not add any new content. They are most commonly induced under the influence of hallucinogenic compounds, such as psychedelics, deliriants, and salvia divinorum.
Tactile enhancement Dose.wiki
Tactile enhancement is an overall increase in both the intensity of a person's sense of touch and their awareness of the physical sensations across their body. It is most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Tactile hallucination Dose.wiki
A tactile hallucination is the experience of perceiving a convincing physical sensation that is not actually occurring. They are most commonly induced under the influence of heavy dosages of deliriant compounds, such as DPH, datura, and benzydamine.
Tactile intimacy enhancement Substance Search
Tactile intimacy enhancement is an increase in the pleasure and emotional meaning of physical closeness, in which touch such as hugging, holding hands, or cuddling feels unusually comforting and significant. It is commonly reported with entactogens and often occurs alongside heightened feelings of affection and trust.
Tactile suppression Dose.wiki
Tactile suppression is a decrease in one's ability to feel their sense of touch, which may result in a general numbness across the body. It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Talkativeness Substance Search
Talkativeness is an increased urge to speak and to engage others in conversation beyond one's usual baseline. Speech may feel easier and faster-flowing, and topics can shift quickly. It is commonly reported under stimulants and entactogens.
Taste distortion Substance Search
Taste distortion is a change in the way things taste, causing familiar foods or drinks to seem different, unusually intense, or unpleasant. It can also appear as a lingering chemical, bitter, or metallic taste with no obvious source. It is commonly reported with substances taken orally or nasally.
Teeth chattering Dose.wiki
Teeth chattering is the experience of a compulsive and often uncontrollably rapid slight opening and closing of a person's mouth, similar to that of when a person is cold or afraid. It is most commonly induced under the influence of heavy dosages of serotonergic compounds, such as MDMA and DXM.
Teeth grinding Dose.wiki
Teeth grinding (also known as bruxism, jaw clenching, and gurning) can be described as a compulsive and often uncontrollable urge to grind one's teeth. It is most commonly induced under the influence of common dosages of stimulant compounds, such as methamphetamine, MDMA, methylphenidate, and cocaine. However, it can also occur under the influence of certain stimulating psychedelics such as 2C-E, DOC, and AMT.
Temperature regulation suppression Dose.wiki
Temperature regulation suppression can be defined as an inability to maintain a normal temperature. It is most commonly induced under the influence of heavy dosages of stimulating psychedelic compounds, such as LSD, 2C-B, and AMT.
Temporary erectile dysfunction Dose.wiki
Temporary erectile dysfunction can be described as a difficulty in achieving and maintaining an adequately erect penis for the purpose of sexual intercourse. It is most commonly induced under the influence of heavy dosages of stimulating compounds, such as traditional stimulants and certain psychedelics. However, it can also occur under the influence of opioids, dissociatives, GABAergics, and deliriants.
Text imagery Substance Search
Text imagery is the appearance of letters, words, numbers, or symbols within visual effects, whether in closed-eye imagery or overlaid on surfaces in the environment. The text often looks meaningful at a glance but tends to shift, blur, or become unreadable when examined directly.
Texture liquidation Dose.wiki
Texture liquidation is the experience of the texture, shape, and general structure of objects and scenery appearing progressively simplified, smudged and stylized in such a way that one's external environment begins to take on the aesthetic of a painting or cartoon. It is most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
The void Substance Search
The void is the experience of finding oneself in a formless, empty space with little or no sensory content, sense of body, or sense of place. It is often described as a vast darkness or nothingness, and reactions to it range from deep peace to fear. It is most commonly reported at heavy doses of dissociative and psychedelic compounds.
Thought acceleration Dose.wiki
Thought acceleration (also known as racing thoughts) is the experience of thought processes being sped up significantly in comparison to that of everyday sobriety. It is most commonly induced under the influence of moderate dosages of stimulant and nootropic compounds, such as amphetamine, methylphenidate, modafinil, and MDMA.
Thought connectivity Dose.wiki
Thought connectivity is an alteration of a person's thought stream which is characterized by a distinct increase in wandering thoughts which connect into each other through a fluid association of ideas. It is most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Thought deceleration Dose.wiki
Thought deceleration is the process of thought being slowed down significantly in comparison to that of normal sobriety. It is most commonly induced under the influence of heavy dosages of depressant compounds, such as GABAergics, antipsychotics, and opioids.
Thought disorganization Dose.wiki
Thought disorganization is a state in which one's ability to analyze and categorize conceptual information using a systematic and logical thought process is considerably decreased. It is most commonly induced under the influence of heavy dosages of hallucinogenic and depressant compounds, such as dissociatives, psychedelics, cannabinoids, and GABAergics.
Thought expansion Substance Search
Thought expansion is the experience of one's thinking feeling broader and more far-reaching than usual, with a single idea branching into many associations, implications, and perspectives at once. Thoughts can feel unusually profound or interconnected, though the sense of insight this produces during intoxication does not guarantee the ideas will hold up afterward.
Thought loops Dose.wiki
A thought loop is the experience of becoming trapped within a chain of thoughts, actions and emotions which repeats itself over and over again in a cyclic loop. Thought loops are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics and dissociatives. However, they can also occur to a lesser extent under the influence of extremely heavy dosages of stimulants and benzodiazepines.
Thought organization Dose.wiki
Thought organization (also known as fluid intelligence) is as a state of mind in which one's ability to analyze and categorize conceptual information using a systematic and logical thought process is considerably increased. It is most commonly induced under the influence of mild dosages of stimulant and nootropic compounds, such as amphetamine, methylphenidate, and Noopept.
Thought suppression Substance Search
Thought suppression is a decrease in the number or intensity of thoughts a person experiences, resulting in a quieter and emptier-feeling mind. At mild levels it can be experienced as a peaceful mental stillness, while at stronger levels it can make it difficult to hold onto or produce any train of thought.
Throat irritation Substance Search
Throat irritation is a raw, scratchy, or sore sensation in the throat. It typically manifests as discomfort when swallowing, speaking, or breathing deeply, and is commonly reported after smoking or vaporizing substances.
Time distortion Dose.wiki
Time distortion is an effect that makes the passage of time feel wildly altered and difficult to keep track of. is most commonly induced under the influence of strong dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and cannabinoids.
Time reversal Substance Search
Time reversal is the perception that time or recent events are flowing backward, as if moments are replaying in reverse order. It is a rare form of time distortion in which the usual forward sequence of experience feels inverted or scrambled rather than simply sped up or slowed down. It is occasionally reported at heavy dosages of psychedelics and dissociatives.
Tinnitus Dose.wiki
Tinnitus is the experience of a sound which is usually described as a ringing, humming, buzzing, roaring, hissing, or clicking that occurs when no corresponding external sound is present. It can occur under the influence of a wide variety of compounds.
Tolerance reduction Substance Search
Tolerance reduction is a return toward a person's original sensitivity to a substance after their response to it has become blunted through repeated use. It most commonly occurs during a break from use, though some people report it in other contexts as well. It is worth knowing that a dose that felt manageable at high tolerance can become far stronger, and more dangerous, once tolerance has fallen.
Tracers Dose.wiki
Tracers are the experience of visual trails of varying lengths and opacity being left behind moving objects. They are most commonly induced under the influence of mild dosages of psychedelic compounds.
Transformations Dose.wiki
Transformations are the experience of a perceived visual metamorphosis that specific parts of one's external environment undergo as they shapeshift into other objects. They are most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Tunnel imagery Substance Search
Tunnel imagery is the perception of tunnel-like visuals, such as corridors, vortices, or concentric rings, that the viewer seems to be looking down or moving through. It most often appears with closed eyes or in darkness and is commonly reported during psychedelic and dissociative experiences, sometimes with a sense of being drawn toward the far end.
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Unity and interconnectedness Dose.wiki
Unity and interconnectedness refers to a feeling in which one's sense of self becomes temporarily expanded to include one or more concepts or systems that would not typically be included within one’s sense of individual identity. It most commonly occurs under the influence of psychedelic and dissociative compounds, such as LSD, DMT, ayahuasca, mescaline, and ketamine.
Unspeakable horrors Dose.wiki
Unspeakable horrors describe the experience of prolonged exposure to indescribable scenarios and hallucinatory content of a scary and disturbing nature, which are often directly influenced by a person's fears. They are most commonly induced under the influence of heavy dosages of psychedelic compounds, such as LSD, psilocybin, and 2C-P.
V
Vasoconstriction Dose.wiki
Vasoconstriction can be described as a narrowing of the veins and blood vessels which results from a contraction of their muscular wall. It is most commonly induced under the influence of moderate dosages of stimulating psychedelic compounds, such as LSD, 2C-E, and DOC.
Vasodilation Dose.wiki
Vasodilation can be described as a widening of the veins and blood vessels which results from the relaxation of smooth muscle cells within the vessel walls. It is most commonly induced under the influence of moderate dosages of cannabinoid compounds, such as cannabis, JWH-018, and THJ-018. However, it can also occur under the influence of poppers and viagra.
Vasomotor symptom relief Substance Search
Vasomotor symptom relief is a lessening of episodes of sudden body-heat disturbance, such as hot flushes, skin flushing, and bouts of sweating. People experiencing it notice these episodes becoming less frequent, less intense, or both. The term is most often used in the context of menopause, where such episodes are common.
Verbal fluency enhancement Substance Search
Verbal fluency enhancement is an increased ability to find words and articulate thoughts through speech. It typically manifests as conversation feeling easier and more effortless than usual, often alongside a general increase in talkativeness and sociability. It is commonly reported under stimulating compounds and under empathy-enhancing substances such as MDMA.
Vibrating sensations Substance Search
Vibrating sensations are feelings of buzzing, humming, or rapid oscillation within the body, ranging from a faint tingle in the limbs to a strong whole-body vibration. They are sometimes reported during the onset of hallucinogenic experiences and may come and go in waves rather than remaining constant.
Vibrating vision Dose.wiki
Vibrating vision, also known as nystagmus, is the experience of constant, rapid involuntary eye movements in which the eyes shift from left to right in such quick succession that the person's vision begins to vibrate and blur. It is most commonly induced under the influence of heavy dosages of stimulant compounds, such as MDMA, amphetamine, and 4-FA.
Visual acuity enhancement Dose.wiki
Visual acuity enhancement is a heightening of the clearness and clarity of vision. It is most commonly induced under the influence of mild dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Visual acuity suppression Dose.wiki
Acuity suppression is the degradation of the sharpness and clarity of one's vision, resulting in vision becoming partially to completely blurred and indistinct. This effect is most commonly induced under the influence of moderate dosages of depressant and dissociative compounds, such as alcohol, quetiapine, ketamine, and DXM.
Visual agnosia Dose.wiki
Visual agnosia is a partial to complete inability to mentally process visual information, regardless of its clarity. It is most commonly induced under the influence of heavy dosages of dissociative or antipsychotic compounds, such as ketamine, quetiapine, PCP, and DXM.
Visual auras Dose.wiki
Visual auras are the experience of glowing fields of translucent emanating colour which surround the edges of a person, an object, or any part of the environment. They are most commonly induced under the influence of moderate dosages of psychedelic compounds.
Visual disconnection Dose.wiki
Visual disconnection is the experience of becoming distanced and/or detached from one's sense of vision. It is a near-universal effect under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Visual distortion Substance Search
Visual distortion is an alteration in the appearance of things a person is actually looking at, as distinct from seeing something that is not there. Common examples include surfaces that appear to drift, breathe, or warp, and changes in the perceived size, distance, or color of objects. Visual distortions are commonly reported under psychedelic and dissociative compounds.
Visual enhancement Substance Search
Visual enhancement is a perceived improvement in the clarity, brightness, or detail of vision. Colors may appear more vivid, edges sharper, and fine textures easier to notice than usual. It is commonly reported under psychedelics.
Visual exposure to inner mechanics of consciousness Dose.wiki
Visual exposure to inner mechanics of consciousness is the experience of being exposed to a mass of visual geometry comprised entirely of innately readable representations which subjectively feel as if they convey the inner mechanics that compose all underlying neurological processes.
Visual exposure to semantic concept network Dose.wiki
Visual exposure to semantic concept network is the experience of percieving a seemingly infinite mass of complex interconnected geometric forms comprised entirely of innately understandable representations. These individual geometric representations are perceived to simultaneously convey every internally stored concept and memory contained within the mind.
Visual flipping Dose.wiki
Visual flipping distorts the surrounding environment to make it appear as if it has been rotated, mirrored, or flipped into an alternative orientation. For example, one's vision may suddenly be viewed as upside down or sideways. This effect is usually very fleeting in its occurrence, typically ranging from a few seconds to less than a minute.
Visual fragmentation Substance Search
Visual fragmentation is a distortion in which the visual field appears to break apart into sections, facets, or repeated fragments, as though the scene were viewed through a cracked lens or assembled from shifting tiles. Objects may seem split, duplicated, or rearranged while remaining individually recognizable. It is sometimes reported at higher intensities of hallucinogenic experiences.
Visual hallucinations Substance Search
Visual hallucinations are perceptions of images, objects, or entire scenes that are not actually present. They range from vague shapes glimpsed at the edge of vision to fully formed and seemingly solid imagery, and the person experiencing them may or may not recognize them as unreal. They are commonly reported under deliriants, at high doses of psychedelics and dissociatives, and during severe sleep deprivation.
Visual haze Dose.wiki
Visual haze distorts the surrounding environment to make it appear as if the air is shrouded in an imaginary cloud of smoke, fog, or haze. It is most commonly induced under the influence of mild dosages of hallucinogenic compounds, such as psychedelics, deliriants, and cannabinoids.
Visual processing acceleration Dose.wiki
Visual processing acceleration increases the speed at which a person can perceive and interpret rapidly occurring events. It is most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Visual snow Substance Search
Visual snow is the perception of fine, grainy static across the field of vision, similar to the noise of an untuned analogue television. It is usually most noticeable when looking at large uniform surfaces such as a blank wall or the sky, and can be subtle enough to go unnoticed. It is commonly reported under psychedelics and can also occur in people who have taken no substance at all.
Visual spiraling Substance Search
Visual spiraling is a distortion in which parts of the visual field appear to twist, rotate, or curl into spiral shapes. Patterned surfaces such as wood grain, carpet, or clouds are especially prone to it, seeming to wind slowly around a central point. It is commonly reported with psychedelics.
Visual stretching Dose.wiki
Visual stretching distorts a person's field of view to make it appear as if it is horizontally or vertically stretching in its size. It is most commonly induced under the influence of heavy dosages of sudden onset hallucinogenic compounds, such as nitrous oxide, DMT, and salvia divinorum. This holds particularly true in the moments immediately preceding ego death.
Visual strobing Dose.wiki
Visual strobing is the experience of a fast-paced and bright flashing light which can occur within one's visual field in manner similar to that of a strobe light. It is most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, DMT, psilocybin, and mescaline.
Visual suppression Substance Search
Visual suppression is a reduction in the clarity, detail, or intensity of vision, experienced as sight that seems dim, blurred, flattened, or less vivid than usual. In stronger forms, parts of the visual field can feel distant or hard to focus on. It is most commonly reported with depressant and dissociative compounds.
Visual twisting Dose.wiki
Visual twisting distorts a person's field of view to make it appear as if it curling into itself, similar to the shape of a spiral. It is most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.
Volume distortion Substance Search
Volume distortion is a change in how loud sounds seem, with noises appearing louder or quieter than they really are, or seeming to swell and fade on their own. Background sounds may leap forward while nearby ones recede, making it difficult to judge how loud anything actually is.
Vomiting Substance Search
Vomiting is the forceful expulsion of stomach contents through the mouth. It often follows nausea and can occur shortly after ingesting a substance or during the come-up. Beyond the discomfort, it matters for safety: vomiting while heavily sedated or unconscious carries a risk of choking, which is why sedated people should be placed in the recovery position.
Vulnerability Substance Search
Vulnerability is a feeling of being emotionally exposed, open, and easily affected by one's surroundings and the people in them. In trusted company it can be experienced as closeness and honesty, while in an unsafe or judgmental setting the same openness can feel distressing.
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Wakefulness Dose.wiki
Wakefulness is an increased ability to stay conscious without feeling sleepy combined with a decreased need to sleep. It is most commonly induced under the influence of moderate dosages of a wide variety of compounds such as stimulants, nootropics, and psychedelics.
Warm bodily numbness Substance Search
Warm bodily numbness is a dulling of physical sensation accompanied by a feeling of warmth spreading through the body. Touch, discomfort, and body awareness all feel muted, while the warmth is often described as a heavy, cozy, blanket-like comfort. Because sensation is dulled, minor injuries or discomfort can go unnoticed while the effect lasts.
Warmth Substance Search
Warmth is a comfortable sensation of heat spreading through the body, often centered in the chest or abdomen and frequently described as a glow. It is commonly reported with opioids, alcohol, and entactogens, and it often blends with an emotional sense of warmth toward oneself and others.
Watery eyes Dose.wiki
Watery eyes can be described as a physical effect which results in a state of continuous involuntary streaming, tearing, crying, and watering of the tear ducts within one's eyes. It is most commonly induced under the influence of moderate dosages of psychedelic tryptamine compounds, such as psilocybin, 4-AcO-DMT, and 4-HO-MET.
Waves of emotion Substance Search
Waves of emotion are surges of feeling that rise, peak, and pass in repeating swells rather than holding at a steady level. The feeling carried by each wave can be positive, negative, or mixed, and successive waves may differ in tone and strength. Depending on intensity, the experience can feel moving, cleansing, or hard to keep up with.
Weight gain Substance Search
Weight gain is an increase in body weight over time. It can result from increased appetite, fluid retention, reduced activity, or changes in how the body stores fat, and may develop gradually enough to go unnoticed at first.
Weight loss Substance Search
Weight loss is a reduction in body weight, which in the context of substance use most often results from sustained appetite suppression and increased physical activity. It is commonly reported with regular use of stimulant compounds and can become a health concern when eating is neglected over extended periods.
Well-being Substance Search
Well-being is a state of feeling comfortable, content, and generally good in both body and mind. It is often described as a quiet background sense that things are alright, rather than an intense rush of pleasure. It can appear on its own or alongside relaxation, sociability, or mood lift.
Withdrawal suppression Substance Search
Withdrawal suppression is a reduction or complete relief of the withdrawal symptoms that arise when a person who has become physically dependent on a substance reduces or stops their use of it. It typically manifests as the easing of symptoms such as restlessness, sweating, aches, anxiety, and cravings. It is commonly reported when a compound with activity similar to the substance a person is dependent on is taken.
Z
Zooming Substance Search
Zooming is a visual distortion in which parts of the environment appear to rush toward or away from the viewer, as if seen through a camera lens changing magnification. Objects may seem to swell closer and then recede, and judging distance can briefly feel unreliable.
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Definitions are descriptive reference material, not medical guidance. Licence: dose.wiki effect index text (CC0); Substance Search-written entries under the site's own terms; referenced replication media are not reproduced here.