The shit is fucking crazy. I would put the general ambient vibe of the drug as an odd and unsettling cross between mushrooms and LSD. Definitely good shit, and I took a lot of it. Zero Hour. I and my friend R are fucking around in some music store in my hometown.
4-HO-DET
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 5 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- 30 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Research-chemical
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 5 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- 30 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Research-chemical
Aliases: Cz-74, Ethocin, 4hodet, 4-hydroxy-det
Summary
4-HO-DET is a research chemical with very little history of human usage. The toxicity and long-term health effects have not been studied in any scientific context. Compared to psilocin, 4-HO-DET has been reported to have a slightly longer duration, less pronounced bodily effects, and more synthetic or algorithmic-style visuals.
Perspectives
“This is perhaps one of the more boring psychedelics I have tasted. The experience does not lend itself to any meaningful thought processes or profound explorations of existence.”
“This was in a gelatin capsule and it came on from a half hour to the three-quarter hour point like gang-busters. Time really slowed down, with sparkly-ness, interesting, and yet there was a touch of sadness. The intense visuals held the scene, and there was the compulsion to talk and to interact and to share stuff, but the erotic was not to be found. I slept OK but there was something uncomfortable at a deep level. Am OK.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 10-15mg | 20-30mg | 30-45mg | 45mg+ |
| Intravenous | 5mg | 10-15mg | 20mg+ | - |
| Smoked | 10-25mg | 25-35mg | 35-60mg | 60mg+ |
Light
Common
Strong
Heavy
Sources· 2 of 3 ladders not identified
Oral
Dose ladder — PsychonautWikiIntravenous
Dose ladder — source not identifiedSmoked
Dose ladder — source not identifiedOnset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 19-45 min | 30-60 min | 2.5-3.5 hrs | 1.5-2 hrs | 3-7 hrs |
| Intravenous | 1-3 min | - | - | - | 3-7 hrs |
| Smoked | 0-1 min | - | - | - | 3-7 hrs |
Effect Profile
11 reportsScores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
8.8
Intense+
9/10
Strong visuals, headspace, and auditory effects with strong body load
Visual Intensity
×3
10
internal hallucinations
colour enhancement
autonomous entities
drifting
tracers
synaesthesia
+9 more
Headspace Depth
×3
10
conceptual thinking
thought connectivity
recursion
emotion enhancement
perspective alterations
perspective distortions
+5 more
Auditory Effects
×1
10
auditory distortion
auditory enhancement
auditory hallucinations
auditory hallucination
synaesthesia
Body Load / Somatic Effects
×1
10
temperature regulation suppression
nausea
muscle tension
teeth grinding
increased heart rate
Based on reports from:
Tolerance
Build-up
develops rapidly after a single use
Reset
7โ14 days for baseline
Tolerance Decay
Full tolerance
1h
Half tolerance
10d
Baseline
~14d
Effects
Aggregated from 11 single-substance Erowid experience reports; 7 Erowid reports where another drug was taken too are left out
Each bar shows the share of analyzed reports whose text mentions that effect — a mention is not always a first-hand experience (fear of an effect or something witnessed can count). Mentions saying the effect did not happen are left out; that check reads keywords, so it can miss some. The shaded band on a bar, and the small range after its number, is the 95% interval: where the share could plausibly be with other reports of the same kind. Fewer reports, wider band. Tap or hover any number for details. The second value is the Bluelight extractor's per-effect confidence; a dash means the row is Erowid-derived, which has no confidence measurement.
Too few reports for bars: these effects come from 11 single-substance Erowid reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?
Effect glossary — · full glossary
Positive Effects 10
10 of 11
–
6 of 11
–
6 of 11
–
6 of 11
–
6 of 11
–
4 of 11
–
4 of 11
–
4 of 11
–
3 of 11
–
3 of 11
–
Adverse Effects 3
5 of 11
–
4 of 11
–
3 of 11
–
Combinations
Cross-Check 4-HO-DET with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 7 reports 5 positive 2 neutral visit
Background: -On no prescription drugs and slightly empty stomach -In my backyard at night -Mindset was positive and interested On the last night that my entire friend group could hang out before the first of us left for college we decided to have a tent night in my backyard, which is somewhat of a tradition now.
Alright, first off Iยll give you a little background information. Iยm 20 years old at the time of my first 4-HO-DET experience and I have a decent amount of experience with psychoactives and hallucinogens.
Intro: Had planned my day out earlier in the week, very clean house, organized spaces, intentions set and a ready mind. Not trying to 'control' things too much but preparing. A perfect day outside in the wild west here, 70 degrees, sunny and mild wind. 9:50am I took 35mg (between 35mg and 40mg, scale problems).
Material - 18 mg ethocin (4-HO-DET) in a gelcap, admistered rectally. Setting - My apartment, various places around the city. Purpose - Entertainment and exploration. -0:30 - Use the bathroom to clear myself out for rectal administration.
Ethocin for some reason always interested me, and a year ago when I passed up the chance to acquire some, I was very saddened. Recently, though, I was able to get my hands on a gram for experimentation. This particular venture was between my significant other of several years, and myself in our home.
I consider myself to be a highly experienced psychonaut, I've had hundreds of experiences with 2C-I, 2C-E, 5-MeO-AMT, 5-MeO-MiPT, 5-MeO-DMT, DOC, 4-AcO-DMT, 4-AcO-MiPT, mushrooms, ayahuasca, LSA, amanita mushrooms, yopo, and I was looking forward to this new tool to add to the bag.
Dose.wiki 1 report 1 neutral visit
This is perhaps one of the more boring psychedelics I have tasted. The experience does not lend itself to any meaningful thought processes or profound explorations of existence, rather it is a dull neutrality that I simply drifted through, gaining nothing.โฆ
Bluelight Reference Guide
Tryptamines The Big & Dandy 4-HO-DET Thread
4-ho-DET has produced some decent experiences. I could have gotten the same experience, with a more chemical feel from MDA. I'd compare it more to MDA than mushrooms... but not as rushy by far.
Read full thread on Bluelight โPiHKAL / TiHKAL
TiHKAL #16: 4-HO-DET
“This was in a gelatin capsule and it came on from a half hour to the three-quarter hour point like gang-busters. Time really slowed down, with sparkly-ness, interesting, and yet there was a touch of sadness. The intense visuals held the scene, and there was the compulsion to talk and to interact and to share stuff, but the erotic was not to be found. I slept OK but there was something uncomfortable at a deep level. Am OK.”
4-HO-DET's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
Add missing routes to PsychonautWiki Journal
The PsychonautWiki Journal app already has 4-HO-DET, but its built-in entry only covers Oral. Here are the other routes we have data for. You can't edit a built-in substance, but you can add a Custom Unit for any of these routes to log it.
⬇ Download import file
Import this file as custom substances
and you get "4-HO-DET (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer. The manual values below work for older
versions.
Custom Unit doses
- Intravenouscommon ~ 12.5 mg
- Smokedcommon ~ 30 mg
Dose & duration (reference)
4-HO-DET: routes the PsychonautWiki Journal app is missing Source: SubstanceSearch (substancesearch.com) Intravenous dose (mg): light 5 ยท common 10-15 ยท strong 20+ Smoked dose (mg): threshold 5 ยท light 10-25 ยท common 25-35 ยท strong 35-60 ยท heavy 60+ Intravenous duration: onset 1-3m ยท total 3-7h ยท after-effects 1-12h Smoked duration: onset 0-1m ยท total 3-7h ยท after-effects 1-12h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Custom Units carry a single dose per route, so the full ranges live in the reference above. A route's suggested dose is the midpoint of its common range. Ranges are harm-reduction guidance, not a prescription.
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for 4-HO-DET? Let us know. Reports are reviewed by moderators — this is not posted publicly.