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    4-HO-DET molecular structure

    4-HO-DET Stats & Data

    Cz-74 Ethocin 4hodet 4-hydroxy-det
    NPS DataHub
    MW232.33
    FormulaC14H20N2O
    CAS22204-89-3
    IUPAC3-(2-diethylaminoethyl)-1H-indol-4-ol
    SMILESCCN(CC)CCc1cnc2cccc(O)c12
    InChIKeyOHHYMKDBKJPILO-UHFFFAOYSA-N
    Tryptamines
    Chemical Class Substituted tryptamine
    Psychoactive Class Psychedelic

    Receptor Profile

    Receptor Actions

    Agonists
    5-HT2A receptor agonist
    5-HT2B receptor agonist
    5-HT2C receptor agonist
    Inhibitors
    Serotonin reuptake inhibitor (low affinity)

    Subjective Effects

    Physical
    • Spontaneous tactile sensations
    • Bodily control enhancement
    • Increased heart rate
    • Nausea
    • Pupil dilation
    • Tactile enhancement
    Cognitive
    • Analysis enhancement
    • Conceptual thinking
    • Delusions
    • Emotion enhancement
    • Immersion enhancement
    • Memory suppression
    • Ego death
    • Novelty enhancement
    • Personal bias suppression
    • Thought acceleration
    • Thought loops
    • Time distortion
    • Unity and interconnectedness
    • Wakefulness
    Sensory
    Auditory
    • Enhancements
    • Distortions
    • Hallucinations
    Visual · Distortions
    • Drifting: (melting, breathing, morphing and flowing)
    • Colour shifting
    • Depth perception distortions
    • Perspective distortions
    • Symmetrical texture repetition
    • Tracers
    Visual · Enhancements
    • Colour enhancement
    • Pattern recognition enhancement
    • Visual acuity enhancement
    Visual · Hallucinatory States
    • Transformations
    • Internal hallucinations: (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots)

    Forked from Subjective Effect Documentation work by Josie Kins, August 2016. Via dose.wiki (CC0).

    Toxicity

    PsychonautWiki

    The toxicity and long-term health effects of recreational 4-HO-DET use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 4-HO-DET is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 4-HO-DET suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. It is strongly recommended that one use harm reduction practices when using this substance.

    Effect Profile

    Curated + 11 Reports
    Psychedelic 8.8

    Strong visuals, headspace, and auditory effects with strong body load

    Visual Intensity×3
    10
    Headspace Depth×3
    10
    Auditory Effects×1
    10
    Body Load / Somatic Effects×1
    10

    Duration Timeline

    Bluelight
    Onset Comeup Peak Offset After Effects
    Oral
    19-45 minutes
    30 minutes - 1.0 hours
    2.5-3.5 hours
    1.5-2 hours
    1-4 hours
    Total: 3-7 hours
    Intravenous
    30-60 minutes hours
    1-12 hours
    Total: 3-7 hours
    Smoked
    0 minutes
    1-12 hours
    Total: 3-7 hours

    Tolerance & Pharmacokinetics

    drugs.wiki

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Cross-Tolerances

    LSD
    Psilocybin
    Psilocin
    Mescaline
    DMT
    5-MeO-DMT
    2C-B
    2C-E

    Experience Report Analysis

    Erowid
    18 Reports
    11 Single-substance
    2004–2020 Date Range
    8 With Age Data
    14 Effects Detected

    Demographics

    Gender Distribution

    Too few reports for a chart: gender is known from 18 reports, and a split is drawn only from 20 reports or more. Counts are shown instead. Why 20?

    • Male 14 of 18
    • Female 4 of 18

    Age Distribution

    Reports Over Time

    Effect Analysis

    Erowid

    Effects aggregated from 11 experience reports (11 single-substance Erowid)

    11 Reports
    14 Effects Detected
    10 Positive
    3 Adverse
    1 Neutral

    Effect Sentiment Distribution

    Confidence Distribution

    Each bar is the share of reports mentioning the effect; its whisker, and the band on the rows below, is the 95% interval: where the share could plausibly be with other reports of the same kind.

    Too few reports for bars: these effects come from 11 single-substance Erowid reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?

    Positive Effects 10

    Visual Distortions 10 of 11 70%
    Introspection 6 of 11 70%
    Music Enhancement 6 of 11 70%
    Stimulation 6 of 11 70%
    Color Enhancement 6 of 11 70%
    Closed-Eye Visuals 4 of 11 70%
    Empathy 4 of 11 70%
    Euphoria 4 of 11 70%
    Open-Eye Visuals 3 of 11 70%
    Focus Enhancement 3 of 11 70%

    Adverse Effects 3

    Confusion 5 of 11 70%
    Anxiety 4 of 11 70%
    Muscle Tension 3 of 11 70%
    Show 1 neutral or unclassified mention
    Sedation 3 of 11

    Dosage Distribution

    Dose distribution from experience reports, one dose per report (the first listed). Doses above Q3 + 3×IQR, far above what people typically take, are left out of the median and range and listed under each route: most are real heavy doses or overdoses, not mistakes.

    Median: 25.0 mg IQR: 25.0–28.8 mg n=11

    Real-World Dose Distribution

    Erowid

    From 19 of 20 recorded dose entries: those that state a weight (mg, g or µg), in routes with at least five of them. Values above Q3 + 3×IQR, far above what people typically take, are left out; they can include real heavy doses and overdoses, not only mistakes.

    Oral (n=18)

    Median: 25.0mg 25th: 25.0mg 75th: 30.0mg 90th: 35.9mg

    Common Combinations

    Most co-occurring substances, as a share of all 18 reports filed under 4-HO-DET

    Too few reports for bars: these combinations come from 18 reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?

    • THC 6 of 18

    Form / Preparation

    Most common forms and preparations, as a share of the 12 reports that give one

    Too few reports for bars: these forms come from 12 reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?

    • Powder / Crystals 8 of 12
    • Capsule 4 of 12

    Redose Patterns

    Redosing behavior across 13 reports

    0 of 13 Redosed
    1.0 Avg Doses

    Too few reports for a chart: redosing is known from 13 reports, and a split is drawn only from 20 reports or more. Counts are shown instead. Why 20?

    • Single dose 13 of 13
    • Redosed 0 of 13

    Legal Status

    Country Status Notes
    Finland Scheduled in the "government decree on psychoactive substances banned from the consumer market".
    Germany 4-HO-DET is controlled under Anlage I BtMG ( Narcotics Act, Schedule I ), former: Opiumgesetz ( Opium Act ) as of February 25, 1967. It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.
    Sweden Sveriges riksdags health ministry Statens folkhälsoinstitut classified 4-HO-DET as "health hazard" under the act Lagen om förbud mot vissa hälsofarliga varor (translated Act on the Prohibition of Certain Goods Dangerous to Health) as of Nov 1, 2005, in their regulation SFS 2005:733 listed as 4-hydroxi-N,N-diethyltryptamin (4-HO-DET), making it illegal to sell or possess.
    Switzerland 4-HO-DET is a controlled substance specifically named under Verzeichnis E.
    United Kingdom 4-HO-DET is a Class A drug in the United Kingdom as a result of the tryptamine catch-all clause.
    United States 4-HO-DET is unscheduled in the United States, but purchase, sale, or possession for human consumption could be prosecuted under the Federal Analogue Act.
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