Ayahuasca Encyclopedic

Encyclopedic

Typical encyclopedia coverage. Cross-reference for important decisions.

5 corroborating sources

descriptive-only dose data

duration data present

28 combo interactions documented

toxicity data (PsychonautWiki)

Aliases: Aya, Cipó, Yage, Yaje, Brew, pharmahuasca

Summary dose.wiki Erowid TripSit PsychonautWiki

Ayahuasca is a brew combining DMT-containing plants with MAOI-containing plants, requiring both components to produce psychoactive effects. Traditional brews vary widely in potency depending on plant sources, preparation methods, and regional practices. The purgative effects (nausea, vomiting, diarrhea) are considered an integral part of the traditional experience and can be intense.

Dose Information source varies by band

ROA	Light	Strong	Heavy
Oral (Traditional B. Caapi + P. Viridis Brew)	Small cup (50-75ml of traditional brew)	Large cup (150-200ml of traditional brew)	Multiple servings or very concentrated brew

Light Strong Heavy

Sources· 1 of 1 ladders not fully identified

Oral (Traditional B. Caapi + P. Viridis Brew)

Dose ladder — Light, Strong: DrugsPRO · Heavy: not identified

Onset, Duration & After-effects dose.wiki PsychonautWiki TripSit

ROA	Onset	Comeup	Peak	Offset	After Effects	Total
Oral (Syrian Rue + Mimosa Hostilis)	19-60 min	30-60 min	1-2 hrs	1-2 hrs	1-8 hrs	5-10 hrs
Oral (Syrian Rue + Acacia Confusa)	19-60 min	30-60 min	1-2 hrs	1-2 hrs	1-8 hrs	4-8 hrs
Oral (Pharmahuasca - Extracted Alkaloids)	15-30 min	19-40 min	1-2 hrs	1-2 hrs	1-6 hrs	4-8 hrs
Oral (Traditional B. Caapi + P. Viridis Brew)	19-60 min	30-60 min	1-2 hrs	1-2 hrs	1-8 hrs	4-8 hrs
Oral	18-60 min	-	1-2 hrs	1-2 hrs	1-8 hrs	4-8 hrs

Effect Profile

137 reports

Scores (0–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Validated against 112 Erowid trip reports
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Psychedelic 8.8

Intense+ 9/10

Strong visuals, headspace, and auditory effects with strong body load

Visual Intensity ×3

internal hallucinations autonomous entity contact autonomous entities colour enhancement synesthesia drifting +7 more

Headspace Depth ×3

conceptual thinking personal meaning enhancement thought connectivity emotional amplification and catharsis feelings of interdependent opposites subconscious communication +8 more

Auditory Effects ×1

auditory distortion auditory enhancement auditory hallucinations synesthesia

⚠ Body Load / Somatic Effects ×1

nausea physical discomfort muscle tension

Empathogen 9.1

Intense+ 9/10

Strong sensory enhancement, empathy, euphoria, and stimulation

Empathy / Social Openness ×3

empathy

Euphoria / Mood Elevation ×2

euphoria emotion enhancement

Stimulation ×1

stimulation restlessness

Sensory Enhancement ×1

enhanced tactile sensation spontaneous tactile sensations colour enhancement acuity enhancement

Stimulant 6.2

Strong 6/10

Strong stimulation with strong anxiety/jitters, moderate euphoria and focus

Stimulation / Energy ×3

stimulation

Euphoria / Mood Lift ×2

euphoria

Focus / Productivity ×2

analysis enhancement thought acceleration

⚠ Anxiety / Jitters ×1

restlessness muscle tension

Based on reports from:

Effect Index My First Experience with Unity Bluelight Big & Dandy Thread Erowid Experience Reports PsychonautWiki Ayahuasca The Drug Users Bible Ayahuasca

Tolerance

Build-up develops rapidly after a single use

Reset 7–14 days for baseline

Tolerance Decay

Full tolerance 1h Half tolerance 10d Baseline ~14d

Cross-Tolerances

Lysergamides

LSD

Tryptamines

Psilocybin

Psilocin

DMT

5-MeO-DMT

Phenethylamines

Mescaline

2C-B

2C-E

Effects Erowid Bluelight

Aggregated from 112 single-substance Erowid and 25 Bluelight experience reports; 29 Erowid reports where another drug was taken too are left out

Each bar shows the share of analyzed reports whose text mentions that effect — a mention is not always a first-hand experience (fear of an effect or something witnessed can count). Mentions saying the effect did not happen are left out; that check reads keywords, so it can miss some. The shaded band on a bar, and the small range after its number, is the 95% interval: where the share could plausibly be with other reports of the same kind. Fewer reports, wider band. Tap or hover any number for details. The second value is the Bluelight extractor's per-effect confidence; a dash means the row is Erowid-derived, which has no confidence measurement.

Positive Effects 51

63.4% –

54.8% 78%

54.5% –

51.8% 84%

42.3% 85%

40.2% 82%

36.0% 83%

36.0% 87%

35.7% 88%

33.6% 90%

28.0% 80%

24.0% 82%

23.2% –

20.0% 91%

20.0% 88%

17.5% 80%

16.8% 82%

16.1% –

16.0% 90%

16.0% 84%

Show 31 more positive effects

16.0% 85%

16.0% 78%

14.6% 89%

12.0% 83%

12.0% 92%

12.0% 83%

12.0% 82%

12.0% 87%

8.0% 85%

8.0% 88%

8.0% 82%

8.0% 85%

8.0% 92%

4.0% 80%

4.0% 85%

4.0% 75%

4.0% 95%

4.0% 90%

4.0% 80%

4.0% 75%

4.0% 80%

4.0% 75%

4.0% 85%

4.0% 90%

4.0% 85%

4.0% 70%

3.6% –

Adverse Effects 33

66.4% 89%

64.2% 87%

36.0% 86%

36.0% 91%

28.0% 85%

26.2% 85%

20.0% 89%

20.0% 78%

13.2% 85%

12.5% –

12.0% 85%

9.5% 82%

8.0% 80%

8.0% 82%

8.0% 85%

8.0% 88%

8.0% 90%

5.9% 80%

4.5% –

4.4% 82%

3.6% –

2.7% –

Show 11 more adverse effects

4.0% 85%

4.0% 75%

4.0% 80%

4.0% 90%

4.0% 80%

4.0% 90%

2.7% –

Also reported in combinations. In the 29 Ayahuasca reports where another drug was taken too, 1 (3.4%) mentions hospital, emergency services or an overdose, 0 (0.0%) a seizure and 2 (6.9%) psychosis. In the 112 single-substance reports: 4.5%, 2.7% and 3.6%. These are not in the figures above: they cannot be put down to Ayahuasca alone, and a mention is not always something that happened to the writer.

Combinations TripSit

Cross-Check Ayahuasca with another substance

Ayahuasca's harmala alkaloids are MAOIs, so these are TripSit's MAOI interactions, plus TripSit's DMT entry on lithium. TripSit's ayahuasca factsheet says to avoid anything contraindicated with MAOIs, particularly SSRIs, MDxx compounds such as MDMA, and amphetamines.

Trip Reports Effect Index

My First Experience with Unity Josie

Community Trip Reports

Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.

Reddit 8 reports 2 positive 6 neutral visit

First time with medicine in Costa Rica neutral r/Ayahuasca ▲7 2 comments

WOW. I had the most amazing experience at a San Pedro retreat at Ananda Lodge in Costa Rica. Blown away by how held, cared for and authentic the owners and center is. Love how intimate the groups were.

I asked and was shown the meaning of life while on Ayahuasca - it wasn’t what i expected and took me years to come to terms with. neutral r/Ayahuasca ▲452 224 comments

I asked the question without even meaning too, so i feel like i had no choice. The next thing i was being pulled up thru a blue swirling funnel as i experienced a life review. The process was incredibly uncomfortable and felt like my soul was being ripped from my body.

A male entity literally left my mouth last weekend during my ceremony and my friend saw it. What on earth was that? neutral r/Ayahuasca ▲240 168 comments

UPDATE: 12/5/2024: Just spoke with my shaman and she explained that she had seen the entity in me when she met me back in April during my first ceremony, but it wasn't ready to come out yet.

I thought ayahuasca would fix me… my experience as someone with OCD neutral r/Ayahuasca ▲45 28 comments

I wanted to share this because I wish I had read something like this before I went into it. I came to ayahuasca from a place of desperation. At that time, I was already dealing with OCD—but it was mostly health anxiety.

The real work was always in the integration, but I didn’t expect it to go that far neutral r/Ayahuasca ▲18 21 comments

From the beginning, I knew that the real work with ayahuasca wasn’t the ceremony itself, but what comes after. The visions and intensity matter, of course, but they felt like openings, not conclusions. What I didn’t expect was how far that integration process would take me.

My ayahuasca experience positive r/Ayahuasca ▲17 2 comments

Ayahuasca was incredible—also unbelievably difficult and physically painful. At one point, I almost canceled my next ayahuasca trip to Peru because of how intense it was. But after the last ceremony, I was completely blown away and in awe.

Jaguar “embodiment” during ayahuasca + lingering physical effects looking for grounded perspectives neutral r/Ayahuasca ▲12 12 comments

Hi everyone, I’m looking for perspectives from people who have experience with ayahuasca, Shipibo traditions, or deep integration work not just surface-level takes. I went to Pucallpa, Peru in December and sat in around 9–10 ayahuasca ceremonies.

Returning to Soltara positive r/Ayahuasca ▲10 7 comments

I’m heading back to Soltara in Costa Rica for my second visit in the past year and a half. The first time I went I hadn’t worked with any plant medicine before. I was struggling in my life back then, I felt stuck and like I was leaking.

Erowid 8 reports 4 positive 4 cautionary visit

The Din of Celestial Birds positive exp #90922

I started my enchanting and beautiful affair with ayahuasca in Goa; which was to mark a very magical end to my sojourn in India. Visionary splendour, ceremonies and nocturnal visits to the realm of spirits. 5 days prior to the ceremonies, I visited a French shaman A.

My Spiritual Limbs Were Tied positive exp #58796

An account of drinking the psychedelic tea Ayahuasca by a long time meditator and spiritual practitioner. My friendship with Robert began in the late 60s. We shared a mutual interest in spirituality and, at that time, we had both experimented with psychedelic substances as a means of arriving at a deeper spiritual und...

A Rookie's Bumbling Notes positive exp #101226

Ayahuasca: a rookie's bumbling notes Among the myriad of vines that make the Amazon jungle their home, there is one with particularly unique properties. The name of that vine is Ayahuasca. When mixed with other Amazonian plants and shrubs into a tea and ingested, it is said to produce powerful hallucinogenic effects.

I'm behind the Underneath cautionary exp #73580

The Second Night (IMO) = In my opinion. I was a more apprehensive on this second night after having recorded the physical and emotional effects of last night, the fragmented stories of others experiences and my own to some degree: the physical payment of vomiting and bodily soreness wasnt it, nor was it even the act...

Allow Yourself to Be Devoured by the Alligator cautionary exp #117847

Allow yourself to be devoured by the Alligator On the 21-09-19 I attended an ayahuasca ceremony in Denmark. Here is a transcript of my diary covering the events. (Drafted on word starting on the 28-12-19. Originally written down in my diary 22-09-19).

Pacha Mama positive exp #116009

My flight from L.A. to Lima was sooooo long! Eight hours with my mask AND face shield left me unrested and annoyed beyond belief! I arrived in Lima and had to wait in the airport for hours before my 4oclock flight to Tarapoto. During the flight I could look down and see mighty rivers and the rainforest below.

Long-Lasting Trauma cautionary exp #104149

I warn you that this report is more than just a simple trip report. It covers many months as the impact of the trip didnt stop after the active molecules had dispersed. I will try (as best as possible) to give a detailed account of what I went through with this powerful psychedelic. It all started around 5 years ago.

Wrestling With Time and Space cautionary exp #111866

INTRO: I decided to try ayahuasca a long time ago, but now I can say with certainty that Im very glad I didnt have a chance to try it in my 20s. I believe this kind of ego-shattering experience requires a lot of mental sobriety and emotional maturity in order not to be confused for a psychotic episode.

Bluelight 8 threads 4 positive 3 neutral 1 cautionary visit

Pharmahuasca The End Of Time Parties With Aliens And Endless Torture positive

Harmala + DMT Extract (Experienced) - The End of Time Celebration and Endless Pain Me: Years of heavy psychedelic experiences coupled with about 100+ breakthrough DMT experiences, of which very few even provided a fraction of this experience.

Ayahuasca First Time Ayahuasca Enlightenment Experience 4 Consecutive Days Dosing positive

Now I would like to post my first great Ayahuasca experience. I am not sure if this is the right thread thou. Ayahuasca enlightenment experience I started to take Ayahuasca 4 days ago, Every day one session. The first 3 sessions were a preparation for what was about to come today.

Ayahuasca In Ecuador positive

Ayahuasca in Ecuador Alright... so I know this cute Canadian chick who introduced me to the idea of trying Ayahuasca. So then I did it. WOW is all I have to fucking say.

Ayahuasca Dose First Time When The Student Is Ready The Teacher Appears neutral

original (Spanish) post: NSFW : El sábado pasado tuve la oportunidad de asistir a una "ceremonia" de ayahuasca en Mexicali B.C. Yo nunca había asistido a ningún evento de este tipo pero sí he leído al respecto, al no tener experiencia pues puedo ser fácilmente "tomado por los pelos" por así decirlo, tengo entendido que...

Ayahuasca First Time Brought Into Being Peace X Piece positive

DMT (Ayahuasca) First time ~ Brought into Being, Peace x Piece 1 teaspoon Syrian Rue powder 11 grams Mimosa Hostilis root bark ½ bowl of weed Note: for those of you who haven’t already, you would due well to also read Spinal’s Ayahuasca report up at the top of trip reports. Our stories are very much intermingled.

Introduction To Pharmahuasca And The Binge neutral

@JackARoe Has been imploring me to start a blog about some of my trip reports that involve certain combinations/doses of psychedelics, and I'm currently scripting a website to host them on.

Ayahuasca First Time Hellfire cautionary

Overview I have spent the past month digesting this experience, and I'll likely continue to process it for a long while to come. This was one of the toughest things I have ever lived through. Over the course of a weekend in Peru, the brew dowsed me repeatedly and without mercy in my own worst fears and memories.

Ayahuasca 1 Glass First Experience Long Lasting Trauma neutral

I warn you that this TR is more than just a simple trip report. It covers many months as the impact of the trip didn’t stop after the active molecules had dispersed. I will try (as best as possible) to give a detailed account of what I went through with this powerful psychedelic. It all started around 5 years ago.

Dose.wiki 6 reports 3 positive 3 neutral visit

My Second Experience with Unity 2.5g Syrian Rue / 6g Mimosa hostillis oral positive

I took the syrian rue by powdering it in a mortar and pestle and washing it down with milk, before waiting approximately 45 minutes to drink down 7 grams of MHRB blended into a banana smoothie. I only managed to drink roughly 6 grams, however, as the sheer…

These voices are the building blocks of consciousness 2g Syrian Rue / 1g Mimosa Hostillis oral neutral

This was definitely an enlightening experience. Many of the thoughts and ideas are a bit fuzzy, which isn’t that odd as they are very much a work in progress, and some of them have already been revised, but I feel like I’ve gained a lot from this. It wasn’t…

Best cake I've had for a while 6g Mimosa / 2.5g Syrian Rue oral - the mimosa was embedded into a cupcake positive

Initially I was nauseous, but the visuals built up and distracted me. They were triangle-based geometric patterns, laced over huge structures: first the triangular wallpaper was emanating from my centre of focus, then I started flying across the top of the…

I was the Universe's prophet 3g mimosa / 2g syrian rue oral - ingested in a banana smoothie (2 bananas, quarter pint of milk, one teaspoon of honey) positive

I was nauseous for the start of the trip, and the closed-eye-visuals looked like the inside of my brain, but black. I purged and thought that I’d be ill for the rest of the trip, but Ayahuasca reassured me, said that this kind of thing happens sometimes, etc.…

My First Proper Psychedelic Experience 3.5g Syrian Rue / 30g Mimosa Hostillis oral neutral

The first thing I noticed was the feeling of my hands melting into my thighs as I was sitting. Then a few minutes later I saw my friend’s face go ‘glitchy’, and his nose stretched and went back to normal. That all happened in a matter of seconds, and I knew I…

Trying to engage in sexual intercourse with the personification of Ayahuasca 3.5g Syrian rue / 50g Mimosa Hostilis oral neutral

I was the last of a group of us to come up (as usual), but I started tripping when I saw fibres of light on everything. I laid down and covered my eyes with my jumper. The first hallucination. I was trying to engage in sexual intercourse with the…

Bluelight Reference Guide Bluelight

The Big & Dandy Oral DMT thread (Ayahuasca/Pharmahuasca)

If i brewed these two together would this make an Ayahuasca brew ? What would be the general dose for these two, anyone know the ratio of syrian rue to Mimosa hostilis is?

Read full thread on Bluelight →

Ayahuasca's nerd page Pharmacology, chemical data, effect profiles, and more

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Helpful Links

📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki 📖 TripSit 📖 Bluelight 📖 The Drug Users Bible

Add missing routes to PsychonautWiki Journal

The PsychonautWiki Journal app already has Ayahuasca, but its built-in entry only covers Oral. Here are the other routes we have data for. You can't edit a built-in substance, but you can add a Custom Unit for any of these routes to log it.

Dose (reference)

Ayahuasca: routes the PsychonautWiki Journal app is missing
Source: SubstanceSearch (substancesearch.com)

Oral (Traditional B. Caapi + P. Viridis Brew) dose (mg): threshold Variable - depends on brew strength and preparation · light Small cup (50-75ml of traditional brew) · strong Large cup (150-200ml of traditional brew) · heavy Multiple servings or very concentrated brew

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

Ranges are harm-reduction guidance, not a prescription.

Report an issue or suggest an edit

Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for Ayahuasca? Let us know. Reports are reviewed by moderators — this is not posted publicly.

Ayahuasca Encyclopedic Encyclopedic Typical encyclopedia coverage. Cross-reference for important decisions. 5 corroborating sources descriptive-only dose data duration data present 28 combo interactions documented toxicity data (PsychonautWiki)

Summary dose.wiki Erowid TripSit PsychonautWiki

Dose Information source varies by band

Oral (Traditional B. Caapi + P. Viridis Brew)

Onset, Duration & After-effects dose.wiki PsychonautWiki TripSit

Effect Profile

Tolerance

Tolerance Decay

Cross-Tolerances

Effects Erowid Bluelight

Positive Effects 51

Adverse Effects 33

Combinations TripSit

Trip Reports Effect Index

Community Trip Reports

Bluelight Reference Guide Bluelight

The Big & Dandy Oral DMT thread (Ayahuasca/Pharmahuasca)

Helpful Links

Report an issue or suggest an edit

Ayahuasca Encyclopedic

Encyclopedic

Typical encyclopedia coverage. Cross-reference for important decisions.

5 corroborating sources

descriptive-only dose data

duration data present

28 combo interactions documented

toxicity data (PsychonautWiki)