Setting: a wilderness trail in the Southwestern U.S., on a gorgeous January afternoon. 20 milligrams 4-AcO-DPT fumarate is insufflated. Within minutes, I can feel an indescribable, perhaps slightly dissociative sensation creeping through my body, and I'm beginning to clearly disconnect from sobriety in a somewhat famil...
4-AcO-DPT
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 30 combo interactions documented
- classified Tentative
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 30 combo interactions documented
- classified Tentative
- classified Research-chemical
Aliases: Depracetin, 4acodpt
Summary
4-AcO-DPT is a research chemical tryptamine first reported around 2012 that acts as a prodrug to 4-HO-DPT through rapid de-acetylation. User reports indicate relatively poor oral bioavailability; intranasal or rectal routes produce shorter but more efficient experiences at roughly half oral doses, though insufflation can cause sharp stinging. The compound produces colorful, fast-moving visuals with pronounced physical stimulation including tremor, jaw tension, and visceral body load, yet comparatively less mystical depth than classic psychedelics.
Perspectives
“This substance is miraculously mentally stimulating. It feels as though it has boundless potential for introspection, therapy, learning, and analytical thinking.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Insufflated | 10-15mg | 15-25mg | 25-35mg | 35mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 30-60 min | 30-60 min | 1-2 hrs | 1-2 hrs | 3-6 hrs |
| Insufflated | 5-10 min | 10-25 min | 30-60 min | 1-2 hrs | 1.75-3.59 hrs |
| Rectal | 10-25 min | 20-40 min | 45-90 min | 1-2 hrs | 2.25-4.59 hrs |
Effect Profile
2 reportsScores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
4.4
Moderate
4/10
Moderate visuals with mild body load and headspace
Visual Intensity
×3
6
color enhancement
drifting
tracers
Headspace Depth
×3
4
introspection
time distortion
confusion
Auditory Effects
×1
0
Body Load / Somatic Effects
×1
5
nausea
teeth grinding
increased heart rate
Based on reports from:
Tolerance
Build-up
develops rapidly after a single use
Reset
7–14 days for baseline
Tolerance Decay
Full tolerance
1h
Half tolerance
10d
Baseline
~14d
Effects
Effect glossary — · full glossary
Positive
Negative
Positive
Negative
Positive
Negative
Combinations
Cross-Check 4-AcO-DPT with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 1 report 1 positive visit
Dose.wiki 1 report 1 neutral visit
This substance is miraculously mentally stimulating. It feels as though it has boundless potential for introspection, therapy, learning, and analytical thinking. It is a gentle fire that warms the mind and activate it into a higher state of functionality. It…
4-AcO-DPT's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track 4-AcO-DPT there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
⬇ Download import file
Import this file as custom substances
and you get "4-AcO-DPT (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer. The manual values below work for older
versions.
Name
4-AcO-DPT
Unit
mg
Description
4-AcO-DPT Source: SubstanceSearch (substancesearch.com) Insufflated dose (mg): light 10-15 · common 15-25 · strong 25-35 · heavy 35+ Oral duration: onset 0.5-1h · come-up 0.5-1h · peak 1-2h · offset 1-2h · total 3-6h · after-effects 2-8h Insufflated duration: onset 5-10m · come-up 10-25m · peak 0.5-1h · offset 1-2h · total 1.75-3.59h · after-effects 2-8h Rectal duration: onset 10-25m · come-up 20-40m · peak 0.75-1.5h · offset 1-2h · total 2.25-4.59h · after-effects 2-8h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 20 mg (Insufflated).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Report an issue or suggest an edit
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