Methoxphenidine Limited data

Limited data

Sparse data. Doses and effects may be unreliable or untested.

6 corroborating sources

1 ROA with full dose ladder

duration data present

29 combo interactions documented

classified Tentative

classified Research-chemical

dose data not in PW/TripSit (unverifiable)

dose ladder unverifiable and undisclosed — capped

Aliases: Mxp, 2-mxp, Methoxyphenidine, 2-meo-diphenidine

Summary dose.wiki Erowid TripSit PsychonautWiki

Methoxphenidine (commonly called MXP or 2-MXP) is a long-acting dissociative of the diarylethylamine class with particularly extended duration. Oral onset can take 1-2 hours, leading inexperienced users to redose prematurely and experience severe intoxication. Doses above 150 mg have produced severe confusion, blackouts, urinary tract irritation similar to ketamine cystitis, and hospitalizations.

Perspectives

“Perhaps it’s the addition of cannabis, or my setting, but overall it provides an exciting and interesting experience that almost feels like an abraded and dulled down psychedelic, devoid of color and with a mysterious damper taking hold of my thoughts and moving them uncontrollably along some predetermined track. Overall it is very buzzy and vibrate-y.”

— Nervewing, nervewing.blogspot.com 150 mg oral

Dose Information dose.wiki TripSit

ROA	Light	Common	Strong	Heavy
Oral	50-75mg	75-120mg	120-150mg	150mg+

Light Common Strong Heavy

Sources

Oral

Dose ladder — dose.wiki, TripSit

Onset, Duration & After-effects dose.wiki TripSit PsychonautWiki

ROA	Onset	Comeup	Peak	Offset	After Effects	Total
Oral	0.5-2 hrs	30-60 min	2-5 hrs	2-3 hrs	6-24 hrs	6-8 hrs
Insufflated	10-45 min	15-30 min	2-4 hrs	1-2 hrs	6-24 hrs	6-8 hrs
Intravenous	30-60 min	-	2-3 hrs	1-2 hrs	6-12 hrs	6-8 hrs

Effect Profile

10 reports

Scores (0–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Dissociative 6.3

Strong 6/10

Strong dissociative depth with strong motor impairment and mania, moderate insight

Dissociative Depth ×3

depersonalization derealization consciousness disconnection tactile disconnection physical disconnection visual disconnection +6 more

⚠ Mania / Compulsion ×1

thought acceleration disinhibition stimulation euphoria

Insight / Novel Thought ×2

conceptual thinking perspective alterations perspective distortions

⚠ Motor / Sensory Impairment ×1

motor control loss tactile disconnection physical disconnection tactile suppression numbness spatial disorientation +2 more

Based on reports from:

Bluelight Big & Dandy Thread Erowid Experience Reports PsychonautWiki Methoxphenidine The Drug Users Bible Methoxphenidine

Tolerance

Build-up develops with repeated use over days to weeks

Reset 2–4 weeks for noticeable reduction

Tolerance Decay

Full tolerance 2d Half tolerance 7d Baseline ~21d

Rapid tolerance build is commonly reported with frequent dissociative use; decay back to baseline typically requires weeks. Values are heuristic aggregates from user reports across dissociatives; specific MXP kinetics are poorly characterized. Avoid consecutive-day use to limit escalation and compulsive redosing.

Cross-Tolerances

Ketamine

DXM

3-MeO-PCP and related arylcyclohexylamines

Effects Erowid

Aggregated from 10 single-substance Erowid experience reports; 20 Erowid reports where another drug was taken too are left out

Each bar shows the share of analyzed reports whose text mentions that effect — a mention is not always a first-hand experience (fear of an effect or something witnessed can count). Mentions saying the effect did not happen are left out; that check reads keywords, so it can miss some. The shaded band on a bar, and the small range after its number, is the 95% interval: where the share could plausibly be with other reports of the same kind. Fewer reports, wider band. Tap or hover any number for details. The second value is the Bluelight extractor's per-effect confidence; a dash means the row is Erowid-derived, which has no confidence measurement.

Too few reports for bars: these effects come from 10 single-substance Erowid reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?

Positive Effects 2

4 of 10 –

3 of 10 –

Adverse Effects 1

3 of 10 –

Also reported in combinations. In the 20 Methoxphenidine reports where another drug was taken too, 2 (10.0%) mention hospital, emergency services or an overdose, 0 (0.0%) a seizure and 3 (15.0%) psychosis. In the 10 single-substance reports: 3, 0 and 0. These are not in the figures above: they cannot be put down to Methoxphenidine alone, and a mention is not always something that happened to the writer.

Combinations TripSit

Cross-Check Methoxphenidine with another substance

Community Trip Reports

Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.

Dose.wiki 1 report 1 neutral visit

The Great Vibration 150mg oral neutral

MXP in my past experiences was never a substance to send me down the “hole”, but in my recent experiments it has surely proven itself. Perhaps it’s the addition of cannabis, or my setting, but overall it provides an exciting and interesting experience that…

Bluelight Reference Guide Bluelight

☛ Official ☚ The Big & Dandy Methoxphenidine / MXP Thread - Part 2 - 'Foxphenny Methoxphenny'?

The Methoxphenidine (2-MeO-Diphenidine) Thread iupac = 1-(1-(2-methoxyphenyl)-2-phenylethyl)piperidine ; (±)-1-[1-(2-methoxyphenyl)-2-phenylethyl]piperidine; (R/S)-1-(1-(2-methoxyphenyl)-2-phenylethyl)piperidine Link to the previous Big & Dandy thread Warnings - MUST read before use: - Long winded Duration: The duratio...

Read full thread on Bluelight →

Methoxphenidine's nerd page Pharmacology, chemical data, effect profiles, and more

→

Helpful Links

📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki 📖 TripSit 📖 Bluelight 📖 The Drug Users Bible

Add missing routes to PsychonautWiki Journal

The PsychonautWiki Journal app already has Methoxphenidine, but its built-in entry only covers Oral. Here are the other routes we have data for. You can't edit a built-in substance, but you can add a Custom Unit for any of these routes to log it.

⬇ Download import file Import this file as custom substances and you get "Methoxphenidine (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.

Duration (reference)

Methoxphenidine: routes the PsychonautWiki Journal app is missing
Source: SubstanceSearch (substancesearch.com)


Insufflated duration: onset 10-45m · come-up 15-30m · peak 2-4h · offset 1-2h · total 6-8h · after-effects 6-24h
Intravenous duration: onset 0.5-1h · peak 2-3h · offset 1-2h · total 6-8h · after-effects 6-12h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

Ranges are harm-reduction guidance, not a prescription.

Report an issue or suggest an edit

Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for Methoxphenidine? Let us know. Reports are reviewed by moderators — this is not posted publicly.