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    Ketamine

    Aliases: k, ket, kitty, kittens

    Categories

    dissociative habit-forming common

    Ketamine structure

    Summary

    A short acting dissociative anaesthetic and hallucinogen commonly used in emergency medicine. It is the prototypical dissociative, and is widely used at sub-anesthetic doses recreationally. Small doses are comparable with alcohol, while larger doses are immobilising and lead to psychedelic experiences: the "K-Hole."

    ⚠️ AVOID: Driving. Moving and walking if possible. Mixing with other depressants like alcohol, benzos and opiates.
    ⚠️ Ketamine is based on weight. These are figures for the average 150 pound male There is no concrete dose for the "K-Hole" as each user is different.

    Dose Information

    Onset, Duration & After-effects

    • Onset:
      • Insufflated: 7.5-20 minutes
      • Intramuscular: 2-7.5 minutes
      • Intravenous: 0-2 minutes
      • Oral: 10-75 minutes
    • Duration: 1-2 hours
    • After-effects: 1-2 hours

    Effects

    Helpful Links

    📘 Experience Reports

    Known Combinations

    These combinations are considered extremely harmful and should always be avoided.

    alcohol: Both substances cause ataxia and bring a very high risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
    ghb/gbl: Both substances cause ataxia and bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
    opioids: Both substances bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.

    These combinations are not usually physically harmful, but may produce undesirable effects.

    amphetamines: No unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this combination may be ill advised due to risk of physical injury.
    benzodiazepines: Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position.
    cocaine: No unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this combination may be ill advised due to risk of physical injury.
    maois: MAO-B inhibitors appear to increase the potency of Ketamine. MAO-A inhbitors have some negative reports associated with the combination but there isn't much information available

    These drugs work together to cause an effect greater than the sum of their parts.

    dextromethorphan: Both substances primarily exert their effects through NMDA antagonism. Currently, there is no evidence regarding mechanisms that might reduce these effects.
    dox: Ketamine and psychedelics tend to potentiate each other - go slowly.
    mdma: No unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this combination may be ill advised due to risk of physical injury.

    Effects are additive. The combination is unlikely to cause any adverse or undesirable reaction.

    caffeine: No unexpected interactions.

    Studies