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    ๐Ÿงช This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    5-MAPB Well-documented
    Well-documented
    Multiple authoritative sources agree on dosing and effects.
    • 5 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 29 combo interactions documented
    • toxicity data (PsychonautWiki)
    • classified Research-chemical

    Aliases: 5mapb

    Summary dose.wiki TripSit PsychonautWiki

    5-MAPB is a potent non-selective monoamine releaser with approximately 3-5 times the potency of MDMA at serotonin and norepinephrine transporters. It functions as a full 5-HT2B receptor agonist, which suggests potential cardiac valve toxicity with repeated use; spacing sessions at least 4-6 weeks apart is strongly advised. Significant batch-to-batch variability in potency has been documented; always use reagent testing and start with a low dose.

    Dose Information PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 40-60mg 60-80mg 80-100mg 100mg+
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — PsychonautWiki

    Onset, Duration & After-effects dose.wiki TripSit PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 19-60 min 45-90 min 2-4 hrs 1.5-3 hrs 6-48 hrs 5-8 hrs
    Insufflated 4-19 min 19-40 min 2-4 hrs 1.5-3 hrs 6-48 hrs 5-8 hrs
    Rectal 15-40 min 30-60 min 2-4 hrs 1.5-3 hrs 6-48 hrs 5-8 hrs
    Intramuscular 10-30 min 19-40 min 2-4 hrs 1.5-3 hrs 6-48 hrs 5-8 hrs

    Effect Profile

    23 reports

    Scores (0–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 2.1
    Light 2/10

    Mild auditory effects with strong body load, low visuals and headspace

    Visual Intensity ×3
    3
    colour enhancement visual acuity enhancement
    Headspace Depth ×3
    1
    time distortion
    Auditory Effects ×1
    4
    music enhancement
    ⚠ Body Load / Somatic Effects ×1
    9
    vasoconstriction nausea teeth grinding increased heart rate sweating
    Empathogen 8.1
    Intense 8/10

    Strong sensory enhancement, empathy, and euphoria with moderate stimulation

    Empathy / Social Openness ×3
    8
    empathy enhancement empathy, affection and sociability enhancement increased sociability
    Euphoria / Mood Elevation ×2
    8
    cognitive euphoria euphoria mood lift
    Stimulation ×1
    7
    stimulation wakefulness teeth grinding increased heart rate
    Sensory Enhancement ×1
    10
    tactile enhancement music enhancement colour enhancement visual acuity enhancement
    Stimulant 6.1
    Strong 6/10

    Strong euphoria and focus with strong anxiety/jitters, mild stimulation

    Stimulation / Energy ×3
    5
    stimulation wakefulness
    Euphoria / Mood Lift ×2
    9
    cognitive euphoria euphoria mood lift motivation enhancement
    Focus / Productivity ×2
    8
    analysis enhancement memory enhancement motivation enhancement thought acceleration
    ⚠ Anxiety / Jitters ×1
    10
    anxiety teeth grinding increased heart rate vasoconstriction sweating

    Tolerance

    No tolerance chart. No study has measured how long tolerance to it lasts, so this page shows what is known instead of a curve.

    No study has measured tolerance to 5-MAPB in people; research so far is on cells, rodents and poisoning cases. PsychonautWiki estimates that tolerance halves in 3-7 days and is gone in 1-2 weeks, and user advice collected by drugs.wiki suggests at least 4-6 weeks between sessions; neither cites a source.

    Sources: Brandt et al. 2020 ยท Hofer et al. 2017 ยท PsychonautWiki: 5-MAPB ยท drugs.wiki (user consensus)

    Cross-Tolerances

    Other serotonin releasers

    Effects Erowid Bluelight

    Aggregated from 8 single-substance Erowid and 15 Bluelight experience reports; 13 Erowid reports where another drug was taken too are left out

    Each bar shows the share of analyzed reports whose text mentions that effect — a mention is not always a first-hand experience (fear of an effect or something witnessed can count). Mentions saying the effect did not happen are left out; that check reads keywords, so it can miss some. The shaded band on a bar, and the small range after its number, is the 95% interval: where the share could plausibly be with other reports of the same kind. Fewer reports, wider band. Tap or hover any number for details. The second value is the Bluelight extractor's per-effect confidence; a dash means the row is Erowid-derived, which has no confidence measurement.

    Rows resting on fewer than 20 reports show a count (“3 of 7”) instead of a bar. Why 20?

    Positive Effects 35

    82.6% (95% interval 63 to 93 percent) 94%
    60.8% (95% interval 41 to 78 percent) 88%
    56.5% (95% interval 37 to 74 percent) 86%
    39.1% (95% interval 22 to 59 percent) 85%
    30.4% (95% interval 16 to 51 percent) 92%
    21.7% (95% interval 10 to 42 percent) 70%
    6 of 15 90%
    6 of 15 85%
    5 of 15 84%
    5 of 15 84%
    4 of 15 84%
    3 of 15 87%
    2 of 15 80%
    2 of 15 80%
    2 of 15 82%
    1 of 15 85%
    1 of 15 75%
    1 of 15 70%
    1 of 15 85%
    1 of 15 75%
    Show 15 more positive effects
    1 of 15 85%
    1 of 15 95%
    1 of 15 85%
    1 of 15 85%
    1 of 15 90%
    1 of 15 65%
    1 of 15 75%
    1 of 15 85%
    1 of 15 90%
    1 of 15 85%
    1 of 15 80%
    1 of 15 85%
    1 of 15 75%
    1 of 15 85%
    1 of 15 80%

    Adverse Effects 12

    43.5% (95% interval 26 to 63 percent) 85%
    6 of 15 79%
    4 of 15 76%
    4 of 15 79%
    2 of 15 88%
    1 of 15 80%
    1 of 15 75%
    1 of 15 80%
    1 of 15 80%
    1 of 15 75%
    1 of 15 80%
    1 of 15 75%

    Also reported in combinations. In the 13 5-MAPB reports where another drug was taken too, 0 mention hospital, emergency services or an overdose, 0 a seizure and 1 psychosis (too few reports for percentages). In the 8 single-substance reports: 0, 0 and 0. These are not in the figures above: they cannot be put down to 5-MAPB alone, and a mention is not always something that happened to the writer.

    Combinations TripSit

    Cross-Check 5-MAPB with another substance

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.

    Erowid 8 reports 2 positive 4 neutral 2 cautionary visit
    Mixed Experience, Strange Hallucinogen cautionary exp #115165

    Mixed Experience, Strange Hallucinogen For context, Iย’d never used an entactogen before 5-MAPB. The acquisition of 5-MAPB came partially from both a desire for something to fill the role of MDMA and an inability to acquire MDMA itself.

    Kadolf B
    Maple Induction Ceremony neutral exp #105576

    Background: It was my first time with this particular substance but Iย’ve done Methylone, MDMA, MDA, and an obscure synthetic cathinone called 4-EMC, so I have experience with euphoric empathogens. I am a 145lb male. T-1.5hr: I had some spicy buffalo wings since I didnย’t have anything in my stomach.

    StarEnthusiast
    Glide Through Euphorant Atmospheres neutral exp #105977

    After I purchased and Marquis tested 7 pristine mg from a trusted vendor I had a few prior purchases from, I found myself a month in and having exercised experience-gathering using carefully--oral and insufflation--chosen RsOA.

    Cryonic_Alchemistry
    Only Slightly Different From MDMA neutral exp #115823

    I obtained some 5-MAPB from a reliable source and decided to try it with a friend. He had to be up very early in the morning, so he didn't want to go all out, so we decided to initially shoot for a low dose.

    TheBaron · 30 mg oral / 15 - 20 mg insufflated / 15 - 20 mg insufflated / 15 - 20 mg insufflated
    Detonated a Sleeping Disorder on Me cautionary exp #116648

    5-MAPB Detonated a Sleeping Disorder on Me I donย’t pretend to alarm nobody with this sensationalist title. Because I donย’t have any proof of it, however I canย’t avoid mixing the clues I have.

    mobbysdick
    Reflections on Initial Use neutral exp #106762

    Night time setting, dorm/frat house type single room. This is two nights of initial research with some 5-MAPB as the primary intoxicant. On the first night I took 40mg nasal in two 20mg doses and 110 oral taken in 3 parachutes of 40 and 60 about 45 minutes apart.

    Bambi · insufflated / oral / oral / oral
    Oddly Reassuring positive exp #118531

    Oddly Reassuring Experience Okay so, I'm Alex (pseudonym) and I'm from the United States. A friend (party animal) of mine took 5-MAPB with him to me from the UK. I thanked him and had the baggie in my backpack for some weeks. After a while, I decided to test the substance (0,5g bag).

    Alex · 50 - 60 mg oral
    Overview and Review positive exp #101651

    Like most my trip reports, this is simply an overview conducted based on memory, which is not my strong point. I feel the need to record my results as this is a novel substance with few reports, yet I can see it taking off sometime in the near-future.

    Infectious · oral
    Bluelight 8 threads 2 positive 5 neutral 1 cautionary visit
    50 Mgs 5 Mapb Quite A Nice Time neutral

    Last night did a dose of 5-mapb together with my girlfriend. I am experienced in empathogeons and this is my second time doing 5-mapb. The first time I did it I had a really intense trip and really bad side effects-I dosed it at 107 mgs weight out (245 lbs) , girlfriend did 70 mgs (165).

    50 mg mentioned in the thread; auto-extracted, unverified
    5 Mapb 3 Different Tries Experienced cautionary

    1st try. It should be stated first that I have been using drugs on a massive scale compared to most people i know for umm 20 or so years. I have had a habit to almost every class of drugs there are. In general I will take more drugs than anyone else and i will enjoy being more fucked up than just about anyone i know.

    5 Mapb 90 Mg Oral 40 Mg Nasal Experienced Summertime Spontanetiy neutral

    OK so I have tested my batch out a few times, but last night was off the chains. Long story short surprise day off taken my me and surprise kids sleep over at in laws and wala on a hot and steamy august night we were free!!!!! Carefully measured out 90 mg for myself and 50 mg for my wife.

    90 mg oral, 40 mg insufflated mentioned in the thread; auto-extracted, unverified
    5 Mapb 90mg First Experience Mind Blown neutral

    I'd like to share this experience as it was my first time with 5-MAPB and also my highest dosage (of the good stuff, there was lots of crap 5-MAPB going around back then that you could easily take a few .1g of and not feel much.) Since this experience I've had many encounters with 5-MAPB and love it dearly as an admixt...

    90 mg mentioned in the thread; auto-extracted, unverified
    5 Mapb 100mg Inexperienced Nearly There neutral

    SUBSTANCE: (1-(benzofuran-5-yl)-N-methylpropan-2-amine) Aka- 5 MAPB APPEARANCE: Light Tan with an almost slightly light orange tint CAS: N/A 5pm: Bombed 100mg of 5-MAPB in a rizla. And so it begins.....

    100 mg mentioned in the thread; auto-extracted, unverified
    5 Mapb 100mg First Time Incredible neutral

    Setting: In my room, quite warm! Substance: 5-MAPB hcl. aka 1-(benzofuran-5-yl)-N-methylpropan-2-amine Appearance: White Powder (from vendor thats been trading since 2007) User: 104KG healthy male, experience with MDMA 80-100mg, Methylone, 4-FA, Mephedrone REPORT t-0 minutes: Oral ROA of 100mg wrapped up in toilet pape...

    100 mg mentioned in the thread; auto-extracted, unverified
    5 Mapb 420mg Really Really Nice positive

    I'm a 30 something male of average build. For comparison I find about 120mg mdmt be purfect but i have been known to enjoy several redoses. Probably a little less with the APB-s but not excessively so and also prone to redose (incidentally avoid doing 4-mmc after, you might find yourself surprised abd taking a moment o...

    420 mg mentioned in the thread; auto-extracted, unverified
    5 Mapb 80 Mg First Time With This Chem Roll At Home Happy Birthday positive

    I weigh 53 kg and am not new to this class of drugs, but this was my first time with 5-MAPB. Setting: my own birthday party at my apartment. We played a concert for the guests and had finished and were feeling very relaxed, all guests were good friends. 22:00 - Took about 80 mg of 5-MAPB orally. SO took 100 mg.

    80 mg mentioned in the thread; auto-extracted, unverified

    Bluelight Reference Guide Bluelight

    The Main 5-MAPB Thread

    1-(benzofuran-5-yl)-N-methylpropan-2-amine this ones just popped up about 2 weeks ago with some of the big vendors. rather expensive at the minute though. any knowledge or experiences with this new intriguing chemical? so far theres only one trip report but it does seem very promising as the next step towards a MDMA re...

    Read full thread on Bluelight โ†’
    →

    Helpful Links

    Add missing routes to PsychonautWiki Journal

    The PsychonautWiki Journal app already has 5-MAPB, but its built-in entry only covers Oral. Here are the other routes we have data for. You can't edit a built-in substance, but you can add a Custom Unit for any of these routes to log it.

    ⬇ Download import file Import this file as custom substances and you get "5-MAPB (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Duration (reference)
    5-MAPB: routes the PsychonautWiki Journal app is missing
    Source: SubstanceSearch (substancesearch.com)
    
    
    Insufflated duration: onset 4-19m ยท come-up 19-40m ยท peak 2-4h ยท offset 1.5-3h ยท total 5-8h ยท after-effects 6-48h
    Rectal duration: onset 15-40m ยท come-up 0.5-1h ยท peak 2-4h ยท offset 1.5-3h ยท total 5-8h ยท after-effects 6-48h
    Intramuscular duration: onset 10-30m ยท come-up 19-40m ยท peak 2-4h ยท offset 1.5-3h ยท total 5-8h ยท after-effects 6-48h
    
    Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Ranges are harm-reduction guidance, not a prescription.