Preface: TMA-2 is a psychedelic amphetamine closely related to mescaline. TMA-2 is just one of a series of the compounds known as the TMAs- short for TriMethoxy Amphetamine. As the name suggests, these are amphetamines with 3-methoxy groups.
TMA-2
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 4 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 30 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Tentative
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 4 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 30 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Tentative
- classified Research-chemical
Aliases: Domeo, 2,5-dimethoxy-4-methoxyamphetamine
Summary
TMA-2 (2,5-dimethoxy-4-methoxyamphetamine) is a synthetic psychedelic amphetamine. It is notably more potent than its positional isomer TMA (3,4,5-trimethoxyamphetamine) and has a limited history of human use. TMA-2 is known for producing unique stimulating effects with less pronounced visual distortions compared to mescaline. Anecdotal reports indicate it is dose-sensitive and can produce uncomfortable body load, nausea, and overstimulation.
Perspectives
“TMA-2 is a challenging but rewarding experience, worthwhile for those willing to suffer the massive lingering bodyload and the overwrought, nonstop stimulation.”
“I took it in two 10 milligram doses, spaced by two hours. There was a slight movement of surface textures, my hearing was deepened and spatially defined. The body was relaxed and stretching seemed necessary. The further I got into it the more I realized that I was totally lazy. Very lethargic, to the point of laughter. At the sixth hour, I was seeing more life in the woodwork, and the wooden angel hanging on the ceiling was flesh and feathers when I stared at it. Great vision. But by no means overwhelming. Sleep was fine.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 10-20mg | 20-40mg | 40-60mg | 60mg+ |
Light
Common
Strong
Heavy
Sources
Oral
Dose ladder — PsychonautWiki, TripSitOnset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 0.33-2 hrs | 1.5-3 hrs | 4-6 hrs | 2-4 hrs | 6-12 hrs |
| Insufflated | 10-30 min | 30-60 min | 4-6 hrs | 2-4 hrs | 6-12 hrs |
| Rectal | 10-30 min | 30-60 min | 4-7 hrs | 3-5 hrs | 6-12 hrs |
| Vaporized | 5-15 min | 20-40 min | 3-6 hrs | 2-4 hrs | 6-12 hrs |
Effect Profile
22 reportsScores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Validated against 22 Erowid trip reports
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
8.4
Intense
8/10
Strong visuals, auditory effects, and headspace with strong body load
Visual Intensity
×3
10
color enhancement
drifting
pattern recognition enhancement
color shifting
after images
brightened colour
+1 more
Headspace Depth
×3
9
conceptual thinking
thought connectivity
emotion enhancement
time distortion
confusion
Auditory Effects
×1
10
auditory distortion
music appreciation enhancement
Body Load / Somatic Effects
×1
10
vasoconstriction
nausea
muscle tension
Stimulant
6.5
Strong
6/10
Strong stimulation with strong anxiety/jitters, moderate focus, mild euphoria
Stimulation / Energy
×3
10
stimulation
wakefulness
Euphoria / Mood Lift
×2
4
euphoria
Focus / Productivity
×2
7
analysis enhancement
thought acceleration
Anxiety / Jitters
×1
10
restlessness
vasoconstriction
muscle tension
Based on reports from:
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3โ7 days for acute; 1โ3 weeks for full reset
Tolerance Decay
Full tolerance
6h
Half tolerance
3d
Baseline
~21d
Acute tolerance develops within hours like other serotonergic psychedelics; functional tolerance typically halves over ~3 days and largely resolves within ~7โ14 days. Crossโtolerance with other classical psychedelics is expected via 5โHT2A downregulation; ratios are rough heuristic values from general psychedelic literature, not TMAโ2 specific measurements.
Effects
Aggregated from 22 single-substance Erowid experience reports; 10 Erowid reports where another drug was taken too are left out
Each bar shows the share of analyzed reports whose text mentions that effect — a mention is not always a first-hand experience (fear of an effect or something witnessed can count). Mentions saying the effect did not happen are left out; that check reads keywords, so it can miss some. The shaded band on a bar, and the small range after its number, is the 95% interval: where the share could plausibly be with other reports of the same kind. Fewer reports, wider band. Tap or hover any number for details. The second value is the Bluelight extractor's per-effect confidence; a dash means the row is Erowid-derived, which has no confidence measurement.
Effect glossary — · full glossary
Positive Effects 12
63.6% (95% interval 43 to 80 percent)
–
54.5% (95% interval 35 to 73 percent)
–
50.0% (95% interval 31 to 69 percent)
–
45.5% (95% interval 27 to 65 percent)
–
22.7% (95% interval 10 to 43 percent)
–
22.7% (95% interval 10 to 43 percent)
–
22.7% (95% interval 10 to 43 percent)
–
18.2% (95% interval 7 to 38 percent)
–
18.2% (95% interval 7 to 38 percent)
–
13.6% (95% interval 5 to 33 percent)
–
13.6% (95% interval 5 to 33 percent)
–
13.6% (95% interval 5 to 33 percent)
–
Adverse Effects 4
45.5% (95% interval 27 to 65 percent)
–
31.8% (95% interval 16 to 53 percent)
–
27.3% (95% interval 13 to 48 percent)
–
13.6% (95% interval 5 to 33 percent)
–
Also reported in combinations. In the 10 TMA-2 reports where another drug was taken too, 0 mention hospital, emergency services or an overdose, 0 a seizure and 2 psychosis (too few reports for percentages). In the 22 single-substance reports: 0.0%, 0.0% and 4.5%. These are not in the figures above: they cannot be put down to TMA-2 alone, and a mention is not always something that happened to the writer.
Combinations
Cross-Check TMA-2 with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 8 reports 3 positive 5 neutral visit
**I didnยt change much from the original notes I made during the trip so you have a better understanding of how I felt during the trip. My conclusion is at the bottom.** ยยยยยยยยยยยยยยยยยยยยยยยยย **Preface:** After having tried 3,4,5-trimethoxyamphetamine (TMA) in February, I decided to check off the other trimethoxyla...
I recently tried TMA-2 for the first time, at 30mg. I'm male, 22, and ~150lbs. I have previous experience with 2C-I,B,E,T2, and Mescaline. I hadn't ingested any psychoactive in almost a year, following a few difficult experiences. This was my first experience with a psychedelic amphetamine.
Relevant Personal Experience: Considerable experience with LSD, MDMA, psilocybin, and various forms of DMT, plus flips and other combinations. Minimal experience with mescaline and analogues: one positive San Pedro ceremony, one okay 2C-B experience (22mg), positive nexus flip and allie flip.
Dissolved Into Life, TMA-2 Recently, I was able to try a compound that I've had a lot of interest in since I ever read Pihkal almost 20 years ago. This compound is TMA-2 (HCL).
I was not expecting much. My boyfriend Z had acquired four TMA-2 capsules the previous year, and had tried a capsule out together with a mutual friend. His only comment afterwards was that the sunset had been particularly stunning, and I had not pressed for further details.
I'd always been interested in TMA-2, its been on the top of my list of RC's to sample for awhile, so when i came into 200mg i was stoked. It is very chemically similar to mescaline, however my interest stemmed from working with an extract of acorus gramineus last year.
[Erowid Note: Driving while intoxicated, tripping, or extremely sleep deprived is dangerous and irresponsible because it endangers other people. Don't do it! ] To 'All the Presidents Men' - with no clear visual distortion. I MUST REMEMBER - an ASC need not have visual disruption as a symptom!.
PiHKAL / TiHKAL
PiHKAL #158: TMA-2
“I took it in two 10 milligram doses, spaced by two hours. There was a slight movement of surface textures, my hearing was deepened and spatially defined. The body was relaxed and stretching seemed necessary. The further I got into it the more I realized that I was totally lazy. Very lethargic, to the point of laughter. At the sixth hour, I was seeing more life in the woodwork, and the wooden angel hanging on the ceiling was flesh and feathers when I stared at it. Great vision. But by no means overwhelming. Sleep was fine.”
TMA-2's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
Add missing routes to PsychonautWiki Journal
The PsychonautWiki Journal app already has TMA-2, but its built-in entry only covers Oral. Here are the other routes we have data for. You can't edit a built-in substance, but you can add a Custom Unit for any of these routes to log it.
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Duration (reference)
TMA-2: routes the PsychonautWiki Journal app is missing Source: SubstanceSearch (substancesearch.com) Insufflated duration: onset 10-30m ยท come-up 0.5-1h ยท peak 4-6h ยท offset 2-4h ยท total 6-12h ยท after-effects 6-12h Rectal duration: onset 10-30m ยท come-up 0.5-1h ยท peak 4-7h ยท offset 3-5h ยท total 6-12h ยท after-effects 6-12h Vaporized duration: onset 5-15m ยท come-up 20-40m ยท peak 3-6h ยท offset 2-4h ยท total 6-12h ยท after-effects 4-12h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Ranges are harm-reduction guidance, not a prescription.
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