This drug is not fun. If you are incredibly desperate to fall asleep, it could be helpful. But I took 50mg around 1am and tried to stay awake, but was asleep by 1:30. I was texting some friends but had to stop due to an overwhelming urge to sleep. My legs felt restless and I was extremely uncomfortable.
Quetiapine
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 4 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- toxicity data (PsychonautWiki, PubChem)
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 4 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- toxicity data (PsychonautWiki, PubChem)
Aliases: Derin, Seroquel, Xeroquel, Ketilept, Ketipinor
Summary
Quetiapine is primarily prescribed for schizophrenia, bipolar disorder, and as adjunct therapy in major depressive disorder. Off-label use for insomnia is common but not recommended due to metabolic side effects, weight gain, and risk of orthostatic hypotension. Recreational misuse is driven by sedative and anxiolytic properties rather than euphoric effects.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 25-50mg | 50-150mg | 150-300mg | 300mg+ |
Light
Common
Strong
Heavy
Sources
Oral
Dose ladder — PsychonautWikiOnset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 20-40 min | 30-60 min | 1.5-6 hrs | 6-7 hrs | 4-8 hrs |
Tolerance
Build-up
develops over 1–4 weeks of regular use
Reset
days to weeks depending on duration of use
Tolerance Decay
Half tolerance
6d
Baseline
~14d
Effects
Aggregated from 60 single-substance Erowid experience reports; 67 Erowid reports where another drug was taken too are left out
Each bar shows the share of analyzed reports whose text mentions that effect — a mention is not always a first-hand experience (fear of an effect or something witnessed can count). Mentions saying the effect did not happen are left out; that check reads keywords, so it can miss some. The shaded band on a bar, and the small range after its number, is the 95% interval: where the share could plausibly be with other reports of the same kind. Fewer reports, wider band. Tap or hover any number for details. The second value is the Bluelight extractor's per-effect confidence; a dash means the row is Erowid-derived, which has no confidence measurement.
Effect glossary — · full glossary
Positive Effects 6
45.0% (95% interval 33 to 58 percent)
–
38.3% (95% interval 27 to 51 percent)
–
15.0% (95% interval 8 to 26 percent)
–
13.3% (95% interval 7 to 24 percent)
–
6.7% (95% interval 3 to 16 percent)
–
5.0% (95% interval 2 to 14 percent)
–
Adverse Effects 5
18.3% (95% interval 11 to 30 percent)
–
16.7% (95% interval 9 to 28 percent)
–
6.7% (95% interval 3 to 16 percent)
–
5.0% (95% interval 2 to 14 percent)
–
5.0% (95% interval 2 to 14 percent)
–
Also reported in combinations. In the 67 Quetiapine reports where another drug was taken too, 13 (19.4%) mention hospital, emergency services or an overdose, 4 (6.0%) a seizure and 13 (19.4%) psychosis. In the 60 single-substance reports: 15.0%, 3.3% and 18.3%. These are not in the figures above: they cannot be put down to Quetiapine alone, and a mention is not always something that happened to the writer.
Community Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 8 reports 3 neutral 5 cautionary visit
Ok, so this is actually two separate stories. Each took place within a week of the other (2006), but the first account was written a few days after, and the second was written about a year later (2007). And it is now being reposted 2 years later (2008).
Well I'm all over the place right now. I'm currently on my daily dose of 200 mg of seroquel for an as of yet undiagnosed psychiatric condition, probably bipolar based on my manic symptoms. I started seroquel treatment 10 days ago.
I've been taking Quetiapine (Seroquel) for insomnia for the last couple months. I am one of the unfortunate group of people who are recovering from substance abuse and addiction, but also have a sleep disorder.
This report is more for people who are being prescribed or thinking about accepting their all-knowing shrink's offer to perscribe them Seroquel, not recreational users... If I ever caught someone using seroquel recreationally I would have to smack them upside the head and laugh in their face as a matter of principle.
[Erowid Note: The doses described in this report are potentially life threatening. The amount taken is beyond a heavy dose and could pose serious health risks or result in unwanted, extreme effects. Doses such as this have been known to cause hospitalizations and/or deaths.
I have been incorrectly diagnosed with different mental illnesses throughout my life, ranging from ADD to Bipolar Disorder. After a great deal of research of the symptoms of various mental conditions I have concluded that there is nothing 'wrong' with me.
I have had anxiety as long as I can remember. I have been diagnosed recently by my psychiatrist as having general anxiety disorder, depression, post traumatic stress disorder, and border line personality disorder. I had a very traumatic childhood, and anxiety runs very strong in my family.
Bluelight 3 threads 3 cautionary visit
I hope this qualifies as a trip report. I'll just go ahead and tell you what went down last night... So it's friday night and I'm watching the baby while my girlfriend is off to work.
So, I'm a freshman where I'm from and very inexperienced when it comes to drugs. Mainly I just smoke pot and drink but I decided one day to try Seroquel because it's all I had, and my dumbass friend "assured" me it would get me high. So anyway, I pop 4 seroquel tablets (100 MG'S) so I've now taken 400 MG of Seroquel.
Took 30 pills of seroquel each 300 mg. I Dont remember much of the time afterwards but I was in my bathroom and then walked downstairs and passed out. My roomates took me to the ER, I was having siezures at this time.
Pill Identifiers
40
known pill identifiers on record — view imprints, colors, shapes, and images
→
Quetiapine's nerd page
Pharmacology, chemical data, effect profiles, and more
→
Helpful Links
Import into PsychonautWiki Journal
The PsychonautWiki Journal app includes Quetiapine, but its built-in data can be thinner than ours. Importing this file adds a separate "Quetiapine (Substance Search)" custom substance with our dose ranges, durations and tolerance, so you can log against whichever you prefer.
⬇ Download import file
Import this file as custom substances
and you get "Quetiapine (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer.
Ranges are harm-reduction guidance, not a prescription.
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for Quetiapine? Let us know. Reports are reviewed by moderators — this is not posted publicly.