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    πŸ§ͺ This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    PRO-LAD Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 30 combo interactions documented
    • toxicity data (PsychonautWiki)
    • classified Tentative
    • classified Research-chemical

    Aliases: N-propylnorlsd, 6-propyl-6-nor-lsd

    Summary dose.wiki TripSit PsychonautWiki

    PRO-LAD is a research chemical with very limited history of human use and minimal scientific documentation regarding its pharmacology, metabolism, and long-term toxicity. Unlike LSD, PRO-LAD has a propyl chain at R6 which may result in slower absorption and different onset characteristics. Users should employ rigorous harm reduction practices including reagent testing, accurate weighing with a microgram scale, and having a trusted sober trip sitter present.

    Perspectives

    “I am aware of some change within a quarter hour, and then nothing more for quite a while. Certainly no visuals, almost like MDMA in that I am not really sure that this is even psychedelicβ€”it does not have any of the flavor of LSD. I want to try it at a higher dose some day.”

    Dose Information PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 50-100Β΅g 100-200Β΅g 200-350Β΅g 350Β΅g+
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — PsychonautWiki

    Onset, Duration & After-effects dose.wiki TripSit PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 30-45 min 30-60 min 2-4 hrs 2-3 hrs 1-4 hrs 6-8 hrs

    Effect Profile

    Scores (0–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 7.2
    Strong+ 7/10

    Strong visuals with moderate headspace, mild auditory effects and body load

    Visual Intensity ×3
    9
    visual patterning and geometry color enhancement drifting tracers visual distortions
    Headspace Depth ×3
    7
    conceptual thinking introspection thought connectivity time distortion
    Auditory Effects ×1
    4
    auditory distortion
    ⚠ Body Load / Somatic Effects ×1
    4
    nausea increased heart rate

    Tolerance

    Build-up develops rapidly after a single use (lysergamide)
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Cross-Tolerances

    Lysergamides

    Effects dose.wiki

    Positive
    Negative
    Neutral
    Positive
    Neutral
    Positive
    Neutral

    Combinations

    Cross-Check PRO-LAD with another substance

    PiHKAL / TiHKAL Shulgin

    TiHKAL #51: PRO-LAD

    “I am aware of some change within a quarter hour, and then nothing more for quite a while. Certainly no visuals, almost like MDMA in that I am not really sure that this is even psychedelicβ€”it does not have any of the flavor of LSD. I want to try it at a higher dose some day.”

    β€” Alexander Shulgin, TiHKAL (with 80 ΞΌg, orally)
    →

    Helpful Links

    Import into PsychonautWiki Journal

    The PsychonautWiki Journal app includes PRO-LAD, but its built-in data can be thinner than ours. Importing this file adds a separate "PRO-LAD (Substance Search)" custom substance with our dose ranges, durations and tolerance, so you can log against whichever you prefer.

    ⬇ Download import file Import this file as custom substances and you get "PRO-LAD (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer.

    Ranges are harm-reduction guidance, not a prescription.