I know this is something I should talk to a therapist about, but I've decided to share it here as well. About 12 days ago, while in a country where I could buy them over the counter, I purchased 30 Lyrica 300mg pills just to experience their effects.
Pregabalin
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 6 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 22 combo interactions documented
- toxicity data (PsychonautWiki, PubChem)
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 6 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 22 combo interactions documented
- toxicity data (PsychonautWiki, PubChem)
Aliases: Lyrica, Nervalin, Pregablin
Summary
Pregabalin (also known as 3-isobutyl GABA and by the trade-name Lyrica) is a depressant substance of the gabapentinoid class. Pregabalin is a common prescription drug, which is typically used to treat neuropathic pain, anxiety, restless leg syndrome, and as an adjunct drug in the treatment of seizures. Pregabalin has a pharmacological profile comparable to that of gabapentin as they both share similar mechanisms of action and induce similar subjective effects.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 50-225mg | 225-600mg | 600-900mg | 900mg+ |
| Rectal | 40-200mg | 200-450mg | 450-600mg | 600mg+ |
Light
Common
Strong
Heavy
Sources
Oral
Dose ladder — PsychonautWikiRectal
Dose ladder — dose.wiki, PsychonautWikiOnset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 30-60 min | 1-2 hrs | 4-6 hrs | 4-8 hrs | 4-17 hrs |
| Insufflated | 15-30 min | 0.5-2 hrs | 2-3 hrs | 3-5 hrs | 6-14 hrs |
| Rectal | 12-30 min | 0.5-2 hrs | 2-3 hrs | 3-5 hrs | 6-14 hrs |
Tolerance
Build-up
develops over 1–2 weeks of daily use
Reset
Falls after you stop, at a rate that varies from person to person. If you've been using regularly, cut down gradually with medical help rather than stopping suddenly.
No tolerance chart. Our decay curves for these drugs were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.
How fast tolerance to these drugs fades after a break has not been measured well enough to draw, so don't count on a dose you used to take still being safe: after time off, start with a much smaller amount and don't use alone. Mixing sedatives with each other, with alcohol or with opioids sharply raises the risk of a fatal overdose. If you've been using regularly, don't stop suddenly: withdrawal from benzodiazepines, alcohol or GHB/GBL can cause seizures or delirium, so get medical help to cut down gradually.
Sources: FRANK: benzodiazepines · Alcohol and Drug Foundation: GHB · FDA 2020: benzodiazepine boxed warning · FDA 2019: gabapentinoids and breathing · NHS: alcohol use disorder
Cross-Tolerances
Effects
Aggregated from 87 single-substance Erowid and 30 Bluelight experience reports; 49 Erowid reports where another drug was taken too are left out
Each bar shows the share of analyzed reports whose text mentions that effect — a mention is not always a first-hand experience (fear of an effect or something witnessed can count). Mentions saying the effect did not happen are left out; that check reads keywords, so it can miss some. The shaded band on a bar, and the small range after its number, is the 95% interval: where the share could plausibly be with other reports of the same kind. Fewer reports, wider band. Tap or hover any number for details. The second value is the Bluelight extractor's per-effect confidence; a dash means the row is Erowid-derived, which has no confidence measurement.
Effect glossary — · full glossary
Positive Effects 48
50.4% (95% interval 42 to 59 percent)
89%
36.7% (95% interval 22 to 54 percent)
83%
30.8% (95% interval 23 to 40 percent)
81%
24.8% (95% interval 18 to 33 percent)
86%
22.2% (95% interval 16 to 31 percent)
86%
20.0% (95% interval 10 to 37 percent)
79%
20.0% (95% interval 10 to 37 percent)
88%
19.7% (95% interval 14 to 28 percent)
84%
17.1% (95% interval 11 to 25 percent)
90%
16.7% (95% interval 7 to 34 percent)
80%
16.2% (95% interval 11 to 24 percent)
77%
13.7% (95% interval 9 to 21 percent)
86%
13.7% (95% interval 9 to 21 percent)
78%
11.1% (95% interval 7 to 18 percent)
86%
11.1% (95% interval 7 to 18 percent)
88%
10.3% (95% interval 6 to 17 percent)
91%
10.0% (95% interval 4 to 26 percent)
82%
10.0% (95% interval 4 to 26 percent)
85%
10.0% (95% interval 4 to 26 percent)
78%
10.0% (95% interval 4 to 26 percent)
83%
Show 28 more positive effects
8.6% (95% interval 5 to 15 percent)
85%
Auditory Effects
6.8% (95% interval 4 to 13 percent)
80%
6.7% (95% interval 2 to 21 percent)
78%
6.7% (95% interval 2 to 21 percent)
80%
6.7% (95% interval 2 to 21 percent)
75%
6.7% (95% interval 2 to 21 percent)
88%
6.7% (95% interval 2 to 21 percent)
80%
6.7% (95% interval 2 to 21 percent)
85%
4.2% (95% interval 2 to 10 percent)
85%
3.3% (95% interval 1 to 17 percent)
85%
3.3% (95% interval 1 to 17 percent)
80%
3.3% (95% interval 1 to 17 percent)
85%
3.3% (95% interval 1 to 17 percent)
85%
Sleep
3.3% (95% interval 1 to 17 percent)
75%
3.3% (95% interval 1 to 17 percent)
65%
3.3% (95% interval 1 to 17 percent)
80%
3.3% (95% interval 1 to 17 percent)
80%
3.3% (95% interval 1 to 17 percent)
75%
3.3% (95% interval 1 to 17 percent)
75%
3.3% (95% interval 1 to 17 percent)
80%
3.3% (95% interval 1 to 17 percent)
95%
3.3% (95% interval 1 to 17 percent)
75%
3.3% (95% interval 1 to 17 percent)
85%
3.3% (95% interval 1 to 17 percent)
85%
3.3% (95% interval 1 to 17 percent)
90%
3.3% (95% interval 1 to 17 percent)
85%
3.3% (95% interval 1 to 17 percent)
80%
3.3% (95% interval 1 to 17 percent)
90%
Adverse Effects 29
33.3% (95% interval 19 to 51 percent)
86%
26.7% (95% interval 14 to 44 percent)
84%
23.3% (95% interval 12 to 41 percent)
80%
23.3% (95% interval 12 to 41 percent)
85%
22.2% (95% interval 16 to 31 percent)
86%
10.0% (95% interval 4 to 26 percent)
78%
9.2% (95% interval 5 to 17 percent)
–
7.7% (95% interval 4 to 14 percent)
72%
6.7% (95% interval 2 to 21 percent)
82%
6.7% (95% interval 2 to 21 percent)
80%
6.7% (95% interval 2 to 21 percent)
80%
6.7% (95% interval 2 to 21 percent)
95%
6.7% (95% interval 2 to 21 percent)
85%
3.3% (95% interval 1 to 17 percent)
95%
3.3% (95% interval 1 to 17 percent)
85%
3.3% (95% interval 1 to 17 percent)
90%
3.3% (95% interval 1 to 17 percent)
85%
3.3% (95% interval 1 to 17 percent)
85%
3.3% (95% interval 1 to 17 percent)
80%
3.3% (95% interval 1 to 17 percent)
80%
Show 9 more adverse effects
3.3% (95% interval 1 to 17 percent)
85%
3.3% (95% interval 1 to 17 percent)
70%
3.3% (95% interval 1 to 17 percent)
80%
3.3% (95% interval 1 to 17 percent)
85%
3.3% (95% interval 1 to 17 percent)
80%
3.3% (95% interval 1 to 17 percent)
80%
3.3% (95% interval 1 to 17 percent)
75%
3.3% (95% interval 1 to 17 percent)
85%
3.3% (95% interval 1 to 17 percent)
85%
Also reported in combinations. In the 49 Pregabalin reports where another drug was taken too, 4 (8.2%) mention hospital, emergency services or an overdose, 4 (8.2%) a seizure and 0 (0.0%) psychosis. In the 87 single-substance reports: 8.0%, 9.2% and 1.1%. These are not in the figures above: they cannot be put down to Pregabalin alone, and a mention is not always something that happened to the writer.
Combinations
Cross-Check Pregabalin with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Reddit 8 reports 2 positive 1 neutral 5 cautionary visit
So I took 600mg two days ago it literally took all away my problems and I could think straight like I used when I was younger, get things done, talk to people way better than I could ever before. Understand my emotions perfectly, repair family issues in just one day by talking.
Hello, I've lurked the sub a lot so I figured I'd share this experience. Initially, my psychiatrist put me on 25mg pregabalin every day to help with anxiety, and that did literally nothing, I was taking that for about a week before this, so I probably got a little bit of toleranc...
NOTE: This post is not a recommendation, it's just anecdotal evidence that only works for me, so take this as an anecdote. My dose is 600mg pregabalin and like 200mg caffeine. Advice Empty stomach: Wait at least 3 hours after tour meal and eat after 2 hours of taking the dose.
If you know anyone who’s about to start treatment with pregabalin or wants to take it recreationally, you could pass this on to them I used to take pregabalin mostly recreationally – I’d take higher doses (150/300) when meeting people or when I needed to boost my creativity, beca...
[](https://www.reddit.com/user/ArabDevastator/) First off, let’s start by saying I have a stutter, I have social anxiety, and I can’t speak two words to save my life. I’m kinda paranoid, and I have no girlfriends or friends whatsoever.
Every post about pregabalin i see people are recommending first time users to take 400mg, 600mg, 900mg. Do you want to kill somebody????? There is evidence of people having seizures because of dosing too much or redosing. Guys, start with 150-225mg.
I went to the ER a couple nights back after consuming around 600mg of Pregabalin. I was feeling super dizzy and anxious, and being the hypochondriac I am, decided to go to emergency.
Erowid 8 reports 3 positive 2 neutral 3 cautionary visit
Ive experimented with Lyrica before. The first time I did 300 mg and the second time I did 400, both were fun but, eh, not much to say. This time, I was intent on getting high, and being out of my usual stash of random mind-bending friends, I jumped on that Lyrica. I took a total of 600 mg.
I am prescribed Lyrica/pregabalin for compressed nerves in my back, I have pretty severe pain from time to time. At the recommended doses for me (100mg 2x a day) it is quite helpful for those pains.
I got Lyrica prescribed to me when I got the shingles. However they are now also being issued out as a medication for nerve damage, and in some cases, pain relief.
I have experience both with long-term use, withdrawal and high dosages of this drug. I've been using pregabalin at 600mg/day for 1.5 years now. Any euphoric feelings from this dosage disappears quickly. The anxiolytic effect, however, remains.
The Strange Psychedelia of Pregabalin Myself and my housemate set aside a night to determine if Pregabalin, could have psychedelic potential. The setting was an outdoor backroom, with television and all the regular comforts, and we have a close relationship, are experienced psychonauts, and were in a healthy mindset.
I'm not a native English speaker. I would like to mention that I used pregabalin a few times prior to this experience. I seem to have a relatively high tolerance to it compared to my friends and other reports I read.
Substance: Pregabalin (Lyrica) Dose: 750 mgs (5 150mg capsules) Setting: Friend's House (Will be referred to as B in the report) It was a normal day, and I was visiting with my friend B at his house. I had recently aquired 10 capsules of Lyrica, brand name for Pregabalin.
When I was in my freshman year of high school, I was extremely depressed. The doctor said it was Bipolar Type II, which means the elevated mood is euphoric and then anxiety kicks in and kills it. The ups arent the problem; my downs are horrible. Suicide has often been rationalized and twice attempted.
Bluelight 7 threads 3 positive 1 neutral 3 cautionary visit
Recently, after about a year-long hiatus, my interest in experimenting with psychoactive substances has been rekindling. I didn't have to work yesterday, nor did I have any other particularly pressing obligations, and for the past couple weeks I've spent most of my spare time feverishly working on my latest artistic pr...
I posted this report this morning on several different forums. I think you'll find it interesting. I have horrible chronic pain from arthritis in my neck and chronic headaches.
So this is a fairly mild dose. 205 lbs male @ 5 ft 11. About 335 mg total. I took the inital 255 mg at 1:30 pm before work, and it takes forever to kick in. Work was a very short useless shift today (hardly anyone in the clinic, holidays) and I bumped the other 80 at about 4:45 pm.
I've been taking a modest dose of pregabalin for a while now, ocasionaly taking more to test the waters. This is what i have to say about it. This is just my personal experience. The feeling or headspace of pregabalin is one of psychedelics or dissociatives in addition to that of a benzo type drug.
T = Time of start dosing T+3 = did 300mg of Pregabalin. Going home. Feeling a little bit happier. T+6 = did 300mg of Pregabalin. It made me super hungry, so I eat a lot, but I was on a diet, so.. it kinda balanced out. T+8 = did 150mg of Pregabalin and 20mg of Diazepam. Feeling really nice in my legs and arms.
FINALLY. After years of trying every SSRI, benzos, anti-psychotics, vistaril, tricylic ADs....and every single street drug. I am a recovering heroin addict. I have injected anything i can get my hands on from meth, coke, heroin, to adderall, buprenorphine, and everclear.
Lyrica (pregabalin) - GHB/XTC/UNIQUE - ultimate bliss @ high dosages.. I hope the moderators do not mind, but I am going to repost my observations and information on Lyrica here as well as on the other drugs forum simply because I overlapped my experience with information that I thought It would be useful.
Pill Identifiers
114
known pill identifiers on record — view imprints, colors, shapes, and images
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Pregabalin's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
Add missing routes to PsychonautWiki Journal
The PsychonautWiki Journal app already has Pregabalin, but its built-in entry only covers Oral, Rectal. Here are the other routes we have data for. You can't edit a built-in substance, but you can add a Custom Unit for any of these routes to log it.
⬇ Download import file
Import this file as custom substances
and you get "Pregabalin (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer. The manual values below work for older
versions.
Duration (reference)
Pregabalin: routes the PsychonautWiki Journal app is missing Source: SubstanceSearch (substancesearch.com) Insufflated duration: onset 15-30m · come-up 0.5-2h · peak 2-3h · offset 3-5h · total 6-14h · after-effects 6-12h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Ranges are harm-reduction guidance, not a prescription.
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for Pregabalin? Let us know. Reports are reviewed by moderators — this is not posted publicly.