Background Information Within the realm of substance experimentation I would classify myself as well versed. I have over a decade of exploration spanning tryptamines, dissociatives, phenethylamines, opioids, opiates, and stimulants.
O-PCE
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 6 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 29 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Tentative
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 6 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 29 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Tentative
- classified Research-chemical
Aliases: 2-dcnek, 2-oxo-pce, Eticyclidone, N-ethyldeschloroketamine, Deschloro-n-ethyl-ketamine, 2'-oxo-pce, opce
Summary
2'-Oxo-PCE (also known as as Eticyclidone, and O-PCE) is a lesser-known novel dissociative substance of the arylcyclohexylamine class that produces dissociative, anesthetic, stimulating and hallucinogenic effects when administered. It is structurally related to arylcyclohexylamines like MXE, 3-MeO-PCE, and deschloroketamine and is speculated to produce its effects through its activity as an NMDA receptor antagonist. The structural similarities O-PCE shares with DCK and ketamine which has been speculated to have antibacterial properties, has raised some concern as to whether it also shares these properties as well.
Perspectives
“This is a spooky substance. It is one of the blankest and most neutral feeling dissociatives I have ever taken. It robs me entirely of emotions, it is neither euphoric nor dysphoric just incredibly blank and grey.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Insufflated BA ~70% | 3-6mg | 6-12mg | 12-20mg | 20mg+ |
| Oral BA ~50% | 1-5mg | 5-10mg | 10-20mg | 20mg+ |
Light
Common
Strong
Heavy
Sources
Insufflated
Dose ladder — PsychonautWikiOral
Dose ladder — dose.wikiOnset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Insufflated | 1-4 min | 4-15 min | 1-2 hrs | 1-2 hrs | 4-6 hrs |
| Oral | 19-40 min | 30-60 min | 2-3 hrs | 1-2 hrs | 3.82-6.67 hrs |
Effect Profile
18 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Dissociative
5.1
Moderate+
5/10
Strong dissociative depth, mania, and motor impairment with low insight
Dissociative Depth
×3
10
depersonalization
derealization
physical disconnection
visual disconnection
physical autonomy
perception of bodily lightness
+3 more
Mania / Compulsion
×1
10
mania
compulsive redosing
disinhibition
stimulation
Insight / Novel Thought
×2
3
conceptual thinking
Motor / Sensory Impairment
×1
10
motor control loss
physical disconnection
tactile suppression
numbness
spatial disorientation
visual disconnection
Based on reports from:
Tolerance
Build-up
develops with repeated use over days to weeks
Reset
2β4 weeks for noticeable reduction
Tolerance Decay
Full tolerance
1d
Half tolerance
7d
Baseline
~14d
Acute tolerance: develops within a single session β the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Rapid tolerance build and partial crossβtolerance across arylcyclohexylamines are widely reported; values above are heuristic and based on anecdotal patterns. Space sessions 10β14 days when possible to reduce escalation risk.
Cross-Tolerances
Effects
Aggregated from 18 Erowid experience reports
Each bar shows the share of analyzed reports whose text mentions that effect — a mention is not always a first-hand experience (fear of an effect, something witnessed, or "did not happen" count too). Tap or hover any number for details. The second value is the Bluelight extractor's per-effect confidence; a dash means the row is Erowid-derived, which has no confidence measurement.
Effect glossary — · full glossary
Positive Effects 11
83.3%
–
77.8%
–
61.1%
–
50.0%
–
44.4%
–
38.9%
–
33.3%
–
22.2%
–
22.2%
–
22.2%
–
16.7%
–
Adverse Effects 8
55.6%
–
50.0%
–
44.4%
–
33.3%
–
22.2%
–
22.2%
–
22.2%
–
16.7%
–
Combinations
Cross-Check O-PCE with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 7 reports 2 positive 3 neutral 2 cautionary visit
This was my third experience with 2'-Oxo-PCE, though it's my first time writing a report on it, and I will be covering a bit of my first two experiences as well. This is my first report on a dissociative in general too, or at least other than being combined with a psychedelic and having the report focus on that, so I'm...
This was my fifth and sixth experiences taking 2'-Oxo-PCE, which occurred on back-to-back days and were close enough to each other for me to consider them like one long high for the sake of reporting.
An Interesting Ketamine's Kinsman I am a 23 year old boy. Approximate weight of 60 kg (although the reported doses are quite separated in time, I deduce that my weight does not vary significantly to notice noticeable changes in these experiences.
One Weird Experience Βthis is a weird substanceΒ is what my computerΒs autocorrect made of the jumble I managed to hack into my keyboard some time after the peak.
I would like to preface this report with a cautionary statement. O-PCE is a very powerful drug. It can and will tear you to shreds with no remorse if you do not treat it with respect.
This is an update on my previous report under the same pseudonym. This report is about a dissociative-anesthetic drug called 2'-Oxo-PCE, which has also been sold as O-PCE, eticyclidone, and 3F-Meo-PCP. CAUTION: I am in no way suggesting people use this substance daily.
Dose.wiki 1 report 1 neutral visit
This is a spooky substance. It is one of the blankest and most neutral feeling dissociatives I have ever taken. It robs me entirely of emotions, it is neither euphoric nor dysphoric just incredibly blank and grey. It has a heavy sinking feeling, it lacks theβ¦
Bluelight Reference Guide
Dissociatives The Big & Dandy Eticyclidone / 2β-Oxo-PCE Thread
IUPAC-Name: 2-(ethylamino)-2-phenylcyclohexan-1-one Other names: O-PCE, Deschloroethylnorketamine, eticyclidone CAS #: 4551-92-2 There has been some confusion over the identity of this compound due to strange naming by vendors. This thread will discuss the above compound.
Read full thread on Bluelight β
O-PCE's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
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