Preface .......... As someone with a keen interest in both dissociatives and neurochemistry, I often run across the infamous ยMK-801ย or ยdizocilpineย in research articles. Usually I think nothing much of it beyond the context of its usual use in research, as who would actually use *that* stuff.
MK-801
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 2 corroborating sources
- partial dose data
- duration data present
- 29 combo interactions documented
- classified Tentative
- classified Research-chemical
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 2 corroborating sources
- partial dose data
- duration data present
- 29 combo interactions documented
- classified Tentative
- classified Research-chemical
Aliases: Dizocilpine, mk801
Summary
Potency is in the microgram range; calibrated 0.1 mg precision scale or volumetric dosing is mandatory. Subjective duration (20-48 h) far exceeds the 2 h rat plasma half-life because of high receptor affinity and slow dissociation. Animal studies show rapid formation of Olney's lesions in the retrosplenial cortex at equivalent doses to 1 mg/kg; human relevance unknown but caution advised.
Dose Information
| ROA | Common |
|---|---|
| Oral / Sublingual | 50-100ug |
| Oral | 50-100ug |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral / Sublingual | 15-60 min | 1-2 hrs | 4-10 hrs | 8-24 hrs | 20-36 hrs |
| Insufflated | 10-30 min | 1-2 hrs | 4-10 hrs | 8-24 hrs | 20-36 hrs |
| Intramuscular | 5-15 min | 30-90 min | 4-10 hrs | 8-24 hrs | 20-36 hrs |
| Rectal | 15-45 min | 1-2 hrs | 4-10 hrs | 8-24 hrs | 20-36 hrs |
| Oral | 15-30 min | - | 20-36 hrs | - | 20-36 hrs |
Effect Profile
1 reportsScores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Dissociative
3.3
Light+
3/10
Mild dissociative depth with mild motor impairment and mania
Dissociative Depth
×3
4
derealization
memory suppression
Mania / Compulsion
×1
4
stimulation
euphoria
Insight / Novel Thought
×2
0
Motor / Sensory Impairment
×1
5
motor control loss
numbness
Based on reports from:
Tolerance
Build-up
develops with repeated use over days to weeks
Reset
2โ4 weeks for noticeable reduction
Tolerance Decay
Full tolerance
1d
Half tolerance
14d
Baseline
~28d
Dissociatives exhibit rapid, session-level tolerance with slow decay over 1โ3 weeks. Frequent redosing extends duration non-linearly and can escalate confusion/insomnia. Cross-tolerance within NMDA antagonists is expected but not quantified in humans; values are heuristic based on user reports and class effects.
Effects
Effect glossary — · full glossary
Positive
Negative
Positive
Negative
Positive
Negative
Combinations
Cross-Check MK-801 with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 3 reports 1 positive 2 neutral visit
'Oh what a treat', I thought as I stared at the glass vial filled with the tiniest amount of grey-white powder, Labeled 'MK-801 Hydrogen Tartrate, Dizocilpine'. And indeed what a treat it was. This was the beginning of probably the weirdest grey-hazy and utterly alien experiences of my life.
The first shot of 50ยตg IM had little effect, some tinnitus. I lay down and experienced a definite slowing of the heart, part of K-programming. Some slow strobing OEV visual effects and also CEV, onset in about 25min. Got aroused and took care of it.. ,-) Orgasm is prolonged, unlike DXM which is counterorgastic.
Bluelight 4 threads 1 positive 3 neutral visit
So decided to try it again, did my typical dosing procedure and wasnt feeling it as much or as quickly, maybe x-tol(cross tolerance)? Took another half flick and went for a swim at the beach with a friend. Walked to beach and back, still not a whole lot.
recently acquired (+)-mk-801 maleate as well as freebase from very reputable source. I was kind of hoping the base would be liquid so i could dilute it with a solvent like ether and smoke it like pcp (i miss my pcp days...). I opened the vial of freebase which was a powder and decided to sample that 1st.
I've experimented with this quite a bit lately and each time was out in public where busting out a mg scale that may or may not be accurate depending how it's feeling was not an absolute necessary option at the point. Ive learned my sweetspot for dosing.
mk-801 trip report, all systems go 200ml=10mg 20ml=1mg 2ml=100um 1ml=50um the first shot of 50um IM had little effect, some tinnitus. i lay down and experienced a definited slowing of myheart, part of kprogramming. some slow strobing visual effects and CEV, onset in about 25min.
MK-801's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
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The PsychonautWiki Journal logging app doesn't include every substance. To track MK-801 there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Name
MK-801
Unit
ยตg
Description
MK-801 Source: SubstanceSearch (substancesearch.com) Oral / Sublingual dose (ยตg): threshold 25ug ยท common 50-100ug Oral dose (ยตg): common 50-100ug Oral / Sublingual duration: onset 0.25-1h ยท come-up 1-2h ยท peak 4-10h ยท offset 8-24h ยท total 20-36h ยท after-effects 24-72h Insufflated duration: onset 10-30m ยท come-up 1-2h ยท peak 4-10h ยท offset 8-24h ยท total 20-36h ยท after-effects 24-72h Intramuscular duration: onset 5-15m ยท come-up 0.5-1.5h ยท peak 4-10h ยท offset 8-24h ยท total 20-36h ยท after-effects 24-72h Rectal duration: onset 15-45m ยท come-up 1-2h ยท peak 4-10h ยท offset 8-24h ยท total 20-36h ยท after-effects 24-72h Oral duration: onset 15-30m ยท peak 20-36h ยท total 20-36h ยท after-effects 1-72h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 75 ยตg (Oral / Sublingual).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
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