I was near the end of a bad love affair with alcohol, and almost feeling like I was coming to the end of my life, because I just love alcohol so much, but she wasn't letting me use her anymore.
Mirtazapine
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 4 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- toxicity data (PsychonautWiki, PubChem)
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 4 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- toxicity data (PsychonautWiki, PubChem)
Aliases: Axit, Avanza, Zispin, Mirtaz, Norset
Summary
Mirtazapine (trade name Remeron and Mirta TAD, among others) is an antidepressant substance of the piperazinoazepine class. At high doses, it has been reported to act as an atypical psychedelic and sedative. It is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA).
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral BA 50% | 7.5-15mg | 15-30mg | 30-45mg | 45mg+ |
Light
Common
Strong
Heavy
Sources· no ladder identified
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 15-60 min | 1.5-3 hrs | 2-6 hrs | 3.75-10 hrs |
Tolerance
Build-up
develops rapidly after a single use
Reset
7–14 days for baseline
Tolerance Decay
Half tolerance
7d
Baseline
~30d
Formal human data on tolerance are limited. Clinically, sedation often diminishes over 1–4 weeks of regular nightly dosing (partial tolerance), while antidepressant benefits generally require sustained dosing and do not show euphoric tolerance patterns. No reliable evidence for cross‑tolerance with classic serotonergic psychedelics; many reports suggest mirtazapine blunts them. Data quality is mainly clinical observation and user reports.
Cross-Tolerances
Sedating antihistamines (H1 antagonists)
Effects
Aggregated from 37 single-substance Erowid experience reports; 29 Erowid reports where another drug was taken too are left out
Each bar shows the share of analyzed reports whose text mentions that effect — a mention is not always a first-hand experience (fear of an effect or something witnessed can count). Mentions saying the effect did not happen are left out; that check reads keywords, so it can miss some. The shaded band on a bar, and the small range after its number, is the 95% interval: where the share could plausibly be with other reports of the same kind. Fewer reports, wider band. Tap or hover any number for details. The second value is the Bluelight extractor's per-effect confidence; a dash means the row is Erowid-derived, which has no confidence measurement.
Effect glossary — · full glossary
Positive Effects 4
51.4% (95% interval 36 to 67 percent)
–
45.9% (95% interval 31 to 62 percent)
–
37.8% (95% interval 24 to 54 percent)
–
10.8% (95% interval 4 to 25 percent)
–
Adverse Effects 5
40.5% (95% interval 26 to 56 percent)
–
13.5% (95% interval 6 to 28 percent)
–
10.8% (95% interval 4 to 25 percent)
–
10.8% (95% interval 4 to 25 percent)
–
8.1% (95% interval 3 to 21 percent)
–
Also reported in combinations. In the 29 Mirtazapine reports where another drug was taken too, 4 (13.8%) mention hospital, emergency services or an overdose, 1 (3.4%) a seizure and 3 (10.3%) psychosis. In the 37 single-substance reports: 5.4%, 0.0% and 0.0%. One or more of the three comes up more often in the combination reports (27.6% against 5.4%), by more than chance would explain; that does not show the combination caused it. These are not in the figures above: they cannot be put down to Mirtazapine alone, and a mention is not always something that happened to the writer.
Combinations
Cross-Check Mirtazapine with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 8 reports 2 positive 3 neutral 3 cautionary visit
This particular drug had been gathering dust on the top shelf of the cabinet for quite some time. In fact, I didnt even know of its recreational potential until I discovered its web page while taking an inventory of every drug in my house.
Mirtazapine: Complete Review and helpful info A long thread, but I have tried to categorise it so you can read what you are looking for, but I would recommend to read everything so you can see the bigger picture. I apologise for any typos in advance, Im not used to writing on my phone.
I suffer from what seems to be or IS fibromalgia and/or similiar muscular/skeletal tension problems. This causes me not horrid pain, but it causes me a form of pain that is constant, throughout my whole body, and is a pain that does not ever go away - EVER.
A few months before, I was taking Zoloft (SSRI), and it worked but it was keeping me up at night, and while I felt decent mentally, I did not have any energy. The fact that I was taking Xanax along with Zoloft to sleep was not helping.
Screaming babies. Parents that won't stop. No space. No privacy. No escape. A sister with a baby, parents that never stopped yelling at anything, no lock on the door. I couldn't take it anymore... So I started smoking & drinking. It amazed me at first how easy it was to hide.
I have suffered with obsessive compulsive disorder, or OCD, since I was 14-years-old. The obsessions stubbornness to abate and also their inherently irrational nature quickly led me to also suffer with anxiety, panic attacks, and depression.
I am a 20 year old male living in the UK and for the last 6 weeks I have been prescribed 30mg of Remeron taken at night before bed for depression, the symptoms of which included erratic sleep patterns, lack of energy, suicidal thoughts and intense feelings of anxiety.
Bluelight 3 threads 3 neutral visit
Remeron has been the ONLY effective anti-depressant I have ever taken. I know meds aren't going to solve my problems but they can keep me alive while I work on those problems. And believe me I'm doing my part. I love the munchies side effect as I quit smoking pot.
So, as a little background info before we embark on this journey, I have EXTENSIVE experience with cannabis and some with a handful of other substances, but my only experience with a psychedelics is DMT and I had a rather high tolerance.
Although mirtazapine is an anti-depressant that is used for sleep and is generally considered to be non-recreational, one of the most insane drug experiences of my life occurred under its influence. it was actually when I was in rehab and was on the first night I ever took it.
Dose.wiki 1 report 1 neutral visit
Started around 8:10 AM, at first didn't experience much other than my stomach feeling hungry and my brain being swimmy, took a hit off my vape (~90% THC). Hunger has flared up, began to experience thought deceleration and decreased processing ability, started…
Pill Identifiers
21
known pill identifiers on record — view imprints, colors, shapes, and images
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Mirtazapine's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
Import into PsychonautWiki Journal
The PsychonautWiki Journal app includes Mirtazapine, but its built-in data can be thinner than ours. Importing this file adds a separate "Mirtazapine (Substance Search)" custom substance with our dose ranges, durations and tolerance, so you can log against whichever you prefer.
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Ranges are harm-reduction guidance, not a prescription.
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