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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Dehydroxyfluorafinil Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 4 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • toxicity data (PsychonautWiki)
    • classified Tentative
    • classified Research-chemical

    Aliases: Fiendz, Modafiendz, N-methylbisfluoromodafinil

    Stimulant Nootropic Research-chemical

    Summary dose.wiki TripSit PsychonautWiki

    N-Methyl-4,4'-difluoro-modafinil (also known as N-Methylbisfluoromodafinil, Dehydroxyfluorafinil, and Modafiendz) is an obscure nootropic of the benzhydryl class with no history of research. Although it is closely related on a structural level to adrafinil and modafinil, neither a pharmacological nor a safety-profile similarity should be assumed.

    Dose Information PsychonautWiki (2016) TripSit

    ROA Light Common Strong Heavy
    Oral 50-100mg 100-150mg 150-200mg 200mg+
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — PsychonautWiki (2016), TripSit

    Onset, Duration & After-effects dose.wiki TripSit PsychonautWiki

    ROA Onset Peak Offset After Effects Total
    Oral 30-60 min 2-4 hrs 2-4 hrs 2-6 hrs 5-8 hrs

    Effect Profile

    Scores (0–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 4.8
    Moderate+ 5/10

    Strong focus with strong anxiety/jitters, mild stimulation, low euphoria

    Stimulation / Energy ×3
    5
    stimulation wakefulness
    Euphoria / Mood Lift ×2
    2
    motivation enhancement
    Focus / Productivity ×2
    9
    focus enhancement memory enhancement motivation enhancement thought acceleration
    ⚠ Anxiety / Jitters ×1
    9
    anxiety increased heart rate vasoconstriction sweating
    Based on reports from:
    PsychonautWiki Dehydroxyfluorafinil
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute tolerance; longer for full reset

    Tolerance Decay

    Full tolerance 7d Half tolerance 7d Baseline ~14d

    Patterns extrapolated from modafinil‑class anecdotal use; daily use for 1–2 weeks often blunts effects, with partial reversal after 3–5 days off and near‑baseline after 2–4 weeks. Data quality is anecdotal, individual variability is high.

    Cross-Tolerances

    Modafinil
    Armodafinil
    Flmodafinil
    Fladrafinil

    Effects dose.wiki

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Dehydroxyfluorafinil's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📖 dose.wiki 📖 PsychonautWiki
    Import into PsychonautWiki Journal

    The PsychonautWiki Journal app includes Dehydroxyfluorafinil, but its built-in data can be thinner than ours. Importing this file adds a separate "Dehydroxyfluorafinil (Substance Search)" custom substance with our dose ranges, durations and tolerance, so you can log against whichever you prefer.

    ⬇ Download import file Import this file as custom substances and you get "Dehydroxyfluorafinil (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer.

    Ranges are harm-reduction guidance, not a prescription.