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    Citicoline Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present

    Aliases: Cdp-choline, Cytidine diphosphate choline

    Nootropic Supplement

    Summary PsychonautWiki

    Citicoline (CDP-choline, cytidine 5'-diphosphocholine) is a water soluble nutrient which serves as a precursor to both choline and cytidine within the brain (which later converts to uridine). To humans, choline is an essential nutrient as its role in reducing the risk of neural tube defects, fatty liver disease, and other pathologies have been documented. CDP-choline is one of the three choline-containing phospholipids that can be orally supplemented (the other two being alpha-GPC and phosphatidylcholine).

    Dose Information dose.wiki PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 100-250mg 250-1000mg 1000-2000mg 2000mg+
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — dose.wiki, PsychonautWiki

    Onset, Duration & After-effects dose.wiki PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 1-2 hrs 2-3 hrs 2.5-3.5 hrs 30-40 hrs 40-60 hrs 35.5-48.5 hrs

    Tolerance

    Build-up varies by mechanism; therapeutic tolerance may develop over weeks of regular use
    Reset typically days to weeks after discontinuation

    Tolerance Decay

    Full tolerance 3d Half tolerance 8d Baseline ~14d

    Effects dose.wiki

    Positive
    Negative
    Neutral
    Positive
    Neutral
    Positive
    Negative
    Neutral
    Citicoline's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki
    Import into PsychonautWiki Journal

    The PsychonautWiki Journal app includes Citicoline, but its built-in data can be thinner than ours. Importing this file adds a separate "Citicoline (Substance Search)" custom substance with our dose ranges, durations and tolerance, so you can log against whichever you prefer.

    ⬇ Download import file Import this file as custom substances and you get "Citicoline (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer.

    Ranges are harm-reduction guidance, not a prescription.