Citicoline Stats & Data
Cdp-choline
Cytidine diphosphate choline
NPS DataHub
MW487.32
FormulaC14H25N4O11P2
CAS987-78-0
IUPAC5-(4-Amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] 2-( ethyl phosphate
SMILES
C[N+](C)(C)CCOP(=O)([O-])OP(=O)([O-])OCC1OC(C(O)C1O)n1ccc(N)nc1=OInChIKey
RZZPDXZPRHQOCG-OJAKKHQRSA-M
Chemical Class
Choline derivative
Pharmacology
DrugBankDescription
Citicoline is a donor of choline in biosynthesis of choline-containing phosphoglycerides. It has been investigated for the treatment, supportive care, and diagnosis of Mania, Stroke, Hypomania, Cocaine Abuse, and Bipolar Disorder, among others.
Receptor Profile
Receptor Actions
Other
Metabolizes to choline and cytidine
enhances acetylcholine synthesis via cholinergic pathways
cytidine converts to uridine enhancing phosphatidylcholine synthesis
increases dopamine and norepinephrine levels in CNS
stimulates glutathione synthesis and glutathione reductase activity
phospholipase A2 inhibition
Tolerance & Pharmacokinetics
drugs.wikiTolerance Decay
Full tolerance
3d
Half tolerance
8d
Baseline
~14d
Experience Report Analysis
Erowid
3
Reports
0
Single-substance
2010–2019
Date Range
3
With Age Data
Demographics
Gender Distribution
Too few reports for a chart: gender is known from 3 reports, and a split is drawn only from 20 reports or more. Counts are shown instead. Why 20?
- Female 1 of 3
- Male 2 of 3
Age Distribution
Reports Over Time
Real-World Dose Distribution
ErowidFrom 5 of 5 recorded dose entries: those that state a weight (mg, g or µg), in routes with at least five of them. Values above Q3 + 3×IQR, far above what people typically take, are left out; they can include real heavy doses and overdoses, not only mistakes.
Oral (n=5)
Median: 500.0mg
25th: 400.0mg
75th: 500.0mg
90th: 2000.0mg