5-APDI Encyclopedic

Encyclopedic

Typical encyclopedia coverage. Cross-reference for important decisions.

4 corroborating sources

1 ROA with full dose ladder

duration data present

30 combo interactions documented

classified Tentative

classified Research-chemical

Aliases: Iap, 2-api, 5-iap, Indanametamine, Indanylamphetamine

Summary dose.wiki Erowid TripSit

5-APDI (IAP) is a potent but weakly selective serotonin-releasing agent with IC50 values of 82 nM for serotonin, 1,848 nM for dopamine, and 849 nM for norepinephrine. Users report empathogenic warmth, mental stimulation, and occasionally mild visuals, but also pronounced body-load including hyperthermia, profuse sweating, bowel urgency, bruxism, and insomnia. Onset is slow; premature redosing has produced serotonin syndrome-like reactions.

Dose Information dose.wiki Drugs.Wiki TripSit

ROA	Light	Common	Strong	Heavy
Oral	15-25mg	25-50mg	50-75mg	75mg+

Light Common Strong Heavy

Sources

Oral

Dose ladder — dose.wiki, Drugs.Wiki, TripSit

Onset, Duration & After-effects dose.wiki TripSit

ROA	Onset	Peak	Offset	After Effects	Total
Oral	30-90 min	2-5 hrs	3-6 hrs	1-6 hrs	5.5-12.5 hrs
Insufflated	5-15 min	2-4 hrs	2-4 hrs	1-6 hrs	4.08-8.25 hrs
Intravenous	1-5 min	2-4 hrs	2-4 hrs	1-6 hrs	4.02-8.08 hrs

Effect Profile

9 reports

Scores (0–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Psychedelic 2.5

Light 2/10

Mild auditory effects with low visuals and body load

Visual Intensity ×3

tracers visual enhancement

Headspace Depth ×3

Auditory Effects ×1

music enhancement

⚠ Body Load / Somatic Effects ×1

teeth grinding sweating

Empathogen 5.1

Moderate+ 5/10

Moderate stimulation with mild empathy, euphoria, and sensory enhancement

Empathy / Social Openness ×3

empathy enhancement increased sociability

Euphoria / Mood Elevation ×2

euphoria mood lift

Stimulation ×1

stimulation wakefulness teeth grinding

Sensory Enhancement ×1

music enhancement visual enhancement

Stimulant 3.5

Moderate 4/10

Mild stimulation and euphoria with moderate anxiety/jitters

Stimulation / Energy ×3

stimulation wakefulness

Euphoria / Mood Lift ×2

euphoria mood lift

Focus / Productivity ×2

⚠ Anxiety / Jitters ×1

anxiety teeth grinding sweating

Based on reports from:

Erowid Experience Reports

Tolerance

Build-up develops over days to weeks of regular use

Reset 3–7 days for acute; 1–3 weeks for full reset

Tolerance Decay

Full tolerance 1d Half tolerance 7d Baseline ~21d

Rapid acute tolerance is frequently reported with SRAs; spacing of several weeks is prudent by analogy to MDMA. Estimates are heuristic and based on anecdotal patterns rather than formal PK/PD studies.

Cross-Tolerances

MDMA

MDA

Other serotonergic empathogens

Effects Erowid

Aggregated from 9 single-substance Erowid experience reports; 7 Erowid reports where another drug was taken too are left out

Each bar shows the share of analyzed reports whose text mentions that effect — a mention is not always a first-hand experience (fear of an effect or something witnessed can count). Mentions saying the effect did not happen are left out; that check reads keywords, so it can miss some. The shaded band on a bar, and the small range after its number, is the 95% interval: where the share could plausibly be with other reports of the same kind. Fewer reports, wider band. Tap or hover any number for details. The second value is the Bluelight extractor's per-effect confidence; a dash means the row is Erowid-derived, which has no confidence measurement.

Too few reports for bars: these effects come from 9 single-substance Erowid reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?

Positive Effects 6

6 of 9 –

5 of 9 –

4 of 9 –

3 of 9 –

Adverse Effects 3

5 of 9 –

4 of 9 –

3 of 9 –

Combinations

Cross-Check 5-APDI with another substance

Community Trip Reports

Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.

Erowid 8 reports 3 positive 5 neutral visit

Reading & TV Watching Become More Engrossing positive exp #28260

I had recently acquired 100mg of IAP. One day while home alone, having nothing to do, I decided to try it out. I attempted to weigh out the material using the liquid measurement technique (which I had previously used with great success on 2C-I).

Almost Like I'm Just Starting to Roll positive exp #34342

After reading several reports about IAP I decided to give the substance a try. The reports I read varied, describing it from totally a waste of time and money to slightly resembling MDMA in some aspects, but in a very mellow and minor sort of way.

Agreeable, Not Worth Repeating neutral exp #29239

Setting: Home, with girlfriend. Southern California, December 2003. 2:20 pm 40 mg IAP ingested, dissolved in vodka. After drinking our shot & a half of vodka, my partner & I sat down to smoke a couple of bowls of good cannabis.

IAP Runup Summary positive exp #27688

- IAP (Indanylamphetamine) runup summary - I recently had the opportunity to sample this novel morsel and put it to the road test with some friends. I had read the initial glowing reports and praises, so had hopes but kinda figured the first reports would be highly subjective and somewhat inaccurate.

Not Quite MDMA, But Interesting neutral exp #26714

I've tried this substance a few times now... started at 20 mg, went to ~30, then 35-40mg. I plan to continue to go upwards a bit on the dosage, but I'm doubting any new revelations are to be had. I'm not going to give an in-depth trip report, just my thoughts on it so far.

Tri-linear Shifts neutral exp #27585

9:05pm- Diluted the white powder in soda and drank it down. Unusual taste that lingered for about 10 minutes. 9:15pm- Onset, light to deeper tingling sensation in the rear-middle of my brain. Get a glass of water and settle in for the ride.

Mr. Nice Guy neutral exp #24668

I have, for a while, been scouring the internet for different contacts in my endless search for knowledge and experience with research chemicals. As it stands, my drug experiences are not spectacular. I don't really do drugs that often, I just happen to find the subject incredibly interesting.

Super Anti-Depressant neutral exp #32814

So this saturday night I was particularly depressed that my social anxiety denied me yet another possible social outing, which left me with a desire to get happy through chemicals. I was contemplating what to do when I remembered that lil baggie of IAP I had acquired some time ago but chickened out on doing.

Bluelight 5 threads 5 neutral visit

Iap First Time Psychonauts Skip This One neutral

<-v IAP v-> buddy of mine ordered sum 2C-I from a reputable source we've used before.. they threw in a free sample of IAP .. .we had never heard of this before... interesting he he. after finding few research materials, mainly erowid, we decided 50mg would be about right.

Iap 2nd Time Kinda Cool neutral

Today I bit the bullet and took 115mg of IAP, my second time with this material. (See this thread for the history). 3:00pm - dose 4:15pm - my notes: -watery/blurry vision -twitching limbs -prickly heat in chest and head and behind eyes -mental processes ...

Iap 50mg 2nd Time Delightfull neutral

This being my second time with IAP left me puzzled, It was bit different from the first time (from the same batch). I dosed round 3:00 or so, and buy 3:30 I was starting to feel "off" not in a good way, uncomfortable and a bit nauseas. This continued as I watched T.v. for about another 45 minutes.

Iap Insufflated First Time Tony Montana Style neutral

IAP...Tony Montana Style 185 lb. Male Around 50mg IAP Insufflated A little over a week ago I snorted 50mg of IAP. There is not very much known about this drug. A few people I know have eaten about 50mg of IAP and didnt experience too much. So I decided to snort it after experiencing rollin for the first time.

Iap First Time Super Anti Depressent neutral

So this saturday night I was particularly depressed that my Social anxiety denied me yet another possible social outing, which left me with a desire to get happy through chemicals. I was contemplating what to do when I remembered that lil baggie of IAP I had acquired some time ago but chickened out on doing.

5-APDI's nerd page Pharmacology, chemical data, effect profiles, and more

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Helpful Links

📘 Experience Reports 📖 dose.wiki

Add to PsychonautWiki Journal

The PsychonautWiki Journal logging app doesn't include every substance. To track 5-APDI there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

⬇ Download import file Import this file as custom substances and you get "5-APDI (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.

Name

5-APDI

Unit

Description

5-APDI
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): light 15-25 · common 25-50 · strong 50-75 · heavy 75+

Oral duration: onset 0.5-1.5h · peak 2-5h · offset 3-6h · total 5.5-12.5h · after-effects 1-6h
Insufflated duration: onset 5-15m · peak 2-4h · offset 2-4h · total 4.08-8.25h · after-effects 1-6h
Intravenous duration: onset 1-5m · peak 2-4h · offset 2-4h · total 4.02-8.08h · after-effects 1-6h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 37.5 mg (Oral).

The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

Report an issue or suggest an edit

Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for 5-APDI? Let us know. Reports are reviewed by moderators — this is not posted publicly.

5-APDI Encyclopedic Encyclopedic Typical encyclopedia coverage. Cross-reference for important decisions. 4 corroborating sources 1 ROA with full dose ladder duration data present 30 combo interactions documented classified Tentative classified Research-chemical