Hello everyone, First of all sorry for my english, hope you can understand! After a long absence I'm back but I preferred to wait a while before coming back because I had a sacred experience .... I'll tell you. First I start with my first test which was the best of all my test.
4-HO-MET
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 5 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- 30 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Research-chemical
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 5 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- 30 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Research-chemical
Aliases: Metocin, Methylcybin, 4homet, homet
Summary
4-HO-MET is a synthetic tryptamine analogue of psilocin first synthesized by Alexander Shulgin. Often described as more recreational than psilocybin mushrooms due to its lighter headspace and more prominent visual effects with less cognitive intensity. Individual response varies significantly; some users report intense experiences at low doses while others report mild effects at higher doses, possibly due to variations in neurochemistry, metabolism, or batch quality.
Perspectives
“4-HO-MET felt kinda like mushrooms, but without the overwhelming-ness or the destruction of autonomy. I was in control, it was like neutered mushrooms, (not necessarily a bad thing), that was also devoid of the emotional aspects of mushrooms that can very easily spiral out of control.”
“This was still a positive low-end experience, with no real negatives or unwanted side effects. I hope to return to this in due course.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-10mg | 10-15mg | 15-25mg | 25mg+ |
| Intravenous | 5mg | 10-15mg | 20mg+ | - |
| Smoked | 10-25mg | 25-35mg | 35-60mg | 60mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 15-40 min | 30-60 min | 2-3 hrs | 60-90 min | 4-6 hrs |
| Insufflated | 5-25 min | - | - | - | 3-7 hrs |
| Intravenous | 2-10 min | - | - | - | 3-7 hrs |
| Smoked | <1-2 min | - | - | - | 25-45 min |
Effect Profile
88 reportsScores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Validated against 60 Erowid trip reports
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
8.0
Intense
8/10
Strong visuals, auditory effects, and headspace with strong body load
Visual Intensity
×3
10
color enhancement
drifting
synaesthesia
pattern recognition enhancement
colour shifting
after images
+1 more
Headspace Depth
×3
8
conceptual thinking
time distortion
Auditory Effects
×1
10
synaesthesia
Body Load / Somatic Effects
×1
10
nausea
temperature regulation suppression
increased heart rate
Tolerance
Build-up
develops rapidly after a single use
Reset
7–14 days for baseline
Tolerance Decay
Full tolerance
6h
Half tolerance
7d
Baseline
~14d
Estimates reflect typical serotonergic psychedelic patterns; individual variability is high and data are anecdotal/community-derived. Redosing within the same day produces diminishing returns.
Cross-Tolerances
Psilocybin/Psilocin
LSD and analogues
Other 4-substituted tryptamines (e.g., 4-AcO-MET/4-HO-MiPT)
Effects
Aggregated from 60 single-substance Erowid and 28 Bluelight experience reports; 44 Erowid reports where another drug was taken too are left out
Each bar shows the share of analyzed reports whose text mentions that effect — a mention is not always a first-hand experience (fear of an effect or something witnessed can count). Mentions saying the effect did not happen are left out; that check reads keywords, so it can miss some. The shaded band on a bar, and the small range after its number, is the 95% interval: where the share could plausibly be with other reports of the same kind. Fewer reports, wider band. Tap or hover any number for details. The second value is the Bluelight extractor's per-effect confidence; a dash means the row is Erowid-derived, which has no confidence measurement.
Effect glossary — · full glossary
Positive Effects 68
65.9% (95% interval 56 to 75 percent)
81%
54.6% (95% interval 44 to 64 percent)
89%
46.4% (95% interval 30 to 64 percent)
86%
43.2% (95% interval 33 to 54 percent)
90%
43.2% (95% interval 33 to 54 percent)
86%
40.9% (95% interval 31 to 51 percent)
82%
39.3% (95% interval 24 to 58 percent)
90%
35.7% (95% interval 21 to 54 percent)
83%
33.0% (95% interval 24 to 43 percent)
91%
32.1% (95% interval 18 to 51 percent)
87%
28.6% (95% interval 15 to 47 percent)
82%
28.6% (95% interval 15 to 47 percent)
83%
28.4% (95% interval 20 to 39 percent)
80%
21.4% (95% interval 10 to 40 percent)
82%
21.4% (95% interval 10 to 40 percent)
92%
21.4% (95% interval 10 to 40 percent)
84%
18.2% (95% interval 12 to 28 percent)
86%
17.9% (95% interval 8 to 36 percent)
81%
17.9% (95% interval 8 to 36 percent)
88%
17.9% (95% interval 8 to 36 percent)
81%
Show 48 more positive effects
15.9% (95% interval 10 to 25 percent)
91%
15.9% (95% interval 10 to 25 percent)
85%
14.3% (95% interval 6 to 32 percent)
81%
14.3% (95% interval 6 to 32 percent)
86%
13.6% (95% interval 8 to 22 percent)
80%
12.5% (95% interval 7 to 21 percent)
85%
10.7% (95% interval 4 to 27 percent)
77%
10.7% (95% interval 4 to 27 percent)
85%
10.7% (95% interval 4 to 27 percent)
77%
10.7% (95% interval 4 to 27 percent)
83%
10.7% (95% interval 4 to 27 percent)
88%
10.7% (95% interval 4 to 27 percent)
82%
10.7% (95% interval 4 to 27 percent)
80%
10.7% (95% interval 4 to 27 percent)
83%
10.7% (95% interval 4 to 27 percent)
87%
10.7% (95% interval 4 to 27 percent)
82%
10.7% (95% interval 4 to 27 percent)
85%
10.7% (95% interval 4 to 27 percent)
83%
10.7% (95% interval 4 to 27 percent)
85%
9.1% (95% interval 5 to 17 percent)
82%
7.1% (95% interval 2 to 23 percent)
88%
7.1% (95% interval 2 to 23 percent)
80%
7.1% (95% interval 2 to 23 percent)
82%
7.1% (95% interval 2 to 23 percent)
85%
7.1% (95% interval 2 to 23 percent)
82%
7.1% (95% interval 2 to 23 percent)
82%
7.1% (95% interval 2 to 23 percent)
90%
7.1% (95% interval 2 to 23 percent)
85%
7.1% (95% interval 2 to 23 percent)
88%
7.1% (95% interval 2 to 23 percent)
72%
7.1% (95% interval 2 to 23 percent)
85%
7.1% (95% interval 2 to 23 percent)
82%
6.8% (95% interval 3 to 14 percent)
80%
3.6% (95% interval 1 to 18 percent)
75%
3.6% (95% interval 1 to 18 percent)
80%
3.6% (95% interval 1 to 18 percent)
80%
3.6% (95% interval 1 to 18 percent)
85%
3.6% (95% interval 1 to 18 percent)
90%
3.6% (95% interval 1 to 18 percent)
70%
3.6% (95% interval 1 to 18 percent)
70%
3.6% (95% interval 1 to 18 percent)
80%
3.6% (95% interval 1 to 18 percent)
80%
3.6% (95% interval 1 to 18 percent)
80%
3.6% (95% interval 1 to 18 percent)
85%
3.6% (95% interval 1 to 18 percent)
75%
3.6% (95% interval 1 to 18 percent)
85%
3.6% (95% interval 1 to 18 percent)
80%
3.6% (95% interval 1 to 18 percent)
85%
Adverse Effects 40
56.8% (95% interval 46 to 67 percent)
82%
42.9% (95% interval 26 to 61 percent)
75%
Auditory Effects
27.2% (95% interval 19 to 37 percent)
81%
26.2% (95% interval 18 to 36 percent)
90%
25.0% (95% interval 13 to 43 percent)
88%
25.0% (95% interval 17 to 35 percent)
77%
20.0% (95% interval 12 to 32 percent)
–
17.9% (95% interval 8 to 36 percent)
86%
17.9% (95% interval 8 to 36 percent)
81%
14.3% (95% interval 6 to 32 percent)
86%
13.6% (95% interval 8 to 22 percent)
85%
12.5% (95% interval 7 to 21 percent)
77%
10.7% (95% interval 4 to 27 percent)
83%
10.7% (95% interval 4 to 27 percent)
78%
10.3% (95% interval 6 to 18 percent)
75%
8.3% (95% interval 4 to 18 percent)
–
7.1% (95% interval 2 to 23 percent)
80%
7.1% (95% interval 2 to 23 percent)
78%
7.1% (95% interval 2 to 23 percent)
85%
7.1% (95% interval 2 to 23 percent)
88%
5.0% (95% interval 2 to 14 percent)
–
Show 19 more adverse effects
6.8% (95% interval 3 to 14 percent)
82%
3.6% (95% interval 1 to 18 percent)
85%
3.6% (95% interval 1 to 18 percent)
85%
3.6% (95% interval 1 to 18 percent)
80%
3.6% (95% interval 1 to 18 percent)
75%
3.6% (95% interval 1 to 18 percent)
85%
3.6% (95% interval 1 to 18 percent)
95%
3.6% (95% interval 1 to 18 percent)
80%
3.6% (95% interval 1 to 18 percent)
85%
3.6% (95% interval 1 to 18 percent)
80%
3.6% (95% interval 1 to 18 percent)
75%
3.6% (95% interval 1 to 18 percent)
70%
3.6% (95% interval 1 to 18 percent)
80%
3.6% (95% interval 1 to 18 percent)
70%
3.6% (95% interval 1 to 18 percent)
80%
3.6% (95% interval 1 to 18 percent)
75%
3.6% (95% interval 1 to 18 percent)
75%
3.6% (95% interval 1 to 18 percent)
80%
3.6% (95% interval 1 to 18 percent)
75%
Also reported in combinations. In the 44 4-HO-MET reports where another drug was taken too, 5 (11.4%) mention hospital, emergency services or an overdose, 1 (2.3%) a seizure and 4 (9.1%) psychosis. In the 60 single-substance reports: 5.0%, 0.0% and 5.0%. These are not in the figures above: they cannot be put down to 4-HO-MET alone, and a mention is not always something that happened to the writer.
Combinations
Cross-Check 4-HO-MET with another substanceTrip Reports
Community Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 7 reports 5 positive 1 neutral 1 cautionary visit
Hello, all. I'm here to share with whatever audience a story of somewhat of a spiritual awakening of 3 people. This is a story of 17-year-old me experimenting with 4-hydroxylized tryptamines with two of my best friends, N and S.
This was my second time with this drug, and the first for my friend. We are both very experienced with a wide variety of classical and novel psychedelics, although we rarely push the doses to the high level and even more rarely take heavy doses.
Setting: My bedroom in my hometown Much has happened since writing up this experience with 4 HO MET [two weeks ago], appearing to be one of many seeds to which my life has blossomed in unexpected directions, for some brief condensed conscious background: I started a new job which has brought about a growing help to mys...
This write-up will cover the last three experiences I've had with metocin since I last uploaded any trip reports. These three trips were all wonderful, but I didn't feel that they all really called for individual reports of their own.
[Erowid Note: Two samples of powder (even of the same chemical) with equivalent volumes won't necessarily weigh the same. For this reason, eyeballing is an inaccurate and potentially dangerous method of measuring, particularly for substances that are active in very small amounts.
7:15PM: Took the dose dissolved in water with my boyfriend. I was really nervous because I had taken a dose of 2-CE recently and it had messed with my stomach to the point where I had a horrible trip and it made me never want to trip again. 7:35PM: I'm feeling really bad effects at this time.
Bluelight 2 threads 2 positive visit
After my last experience with smoked DMT, I was left with the feeling that I had been shown all that this particular material would be able to show me at this point in my life. Coming down from my last DMT flash, I felt a voice of guidance communicate to me to return to exploring the sacred mushroom and Ayahuasca.
After my first experience with metocin I felt inclined to try to achieve “vegetable television” with this material. “Vegetable television” is a term that was used most famously by Terence McKenna to describe the state of combining psilocybin/psilocin mushrooms with a dose of smoked Syrian rue (Peganum harmala) seeds.
Dose.wiki 4 reports 2 neutral 2 cautionary visit
I cannot believe I experienced unity twice in one week after not undergoing it for well over four years. It was completely unexpected. Although I may be wrong, I get the feeling that I will not experience unity again until I am in the next chapter of my life,…
I am incredibly lucky to have experienced this state, especially from the vantage point of a human being which is less indoctrinated into mystical and religious thinking than the average person. I will spend the next few days, weeks and months analysing this…
I am trying to settle the debate as to whether 4-AcO tryptamines are active on their own or whether they get completely metabolized into the 4-HO variant, with the experience owing all of its effects to this 4-HO metabolite. Honestly you can’t really settle…
This substance surprised me with the stylistic and qualitative differences of the visuals as compared to 4-HO-DMT. The content of hallucinations was often humorous, referential to popular culture, and gave a feeling opposite to spiritual depth. There was…
Bluelight Reference Guide
Tryptamines The Big & Dandy 4-HO-MET Thread - Part 3 - 4-HO-ME's for life
Welcome to the Big & Dandy 4-HO-MET Thread - Version 3 CAS# for freebase: 77872-41-4 Previous threads: Previous Big & Dandy Thread (Part 2) First Big & Dandy Thread Subthreads: Solubility & stability Health & safety External Links: Wikipedia Page on 4-HO-MET Erowid 4-HO-MET Vault Erowid Trip Reports Excerpt from TIHKAL...
Read full thread on Bluelight →PiHKAL / TiHKAL
4-HO-MET's nerd page
Pharmacology, chemical data, effect profiles, and more
→
Helpful Links
Add missing routes to PsychonautWiki Journal
The PsychonautWiki Journal app already has 4-HO-MET, but its built-in entry only covers Oral, Smoked. Here are the other routes we have data for. You can't edit a built-in substance, but you can add a Custom Unit for any of these routes to log it.
⬇ Download import file
Import this file as custom substances
and you get "4-HO-MET (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer. The manual values below work for older
versions.
Custom Unit doses
- Intravenouscommon ~ 12.5 mg
Dose & duration (reference)
4-HO-MET: routes the PsychonautWiki Journal app is missing Source: SubstanceSearch (substancesearch.com) Intravenous dose (mg): light 5 · common 10-15 · strong 20+ Insufflated duration: onset 5-25m · total 3-7h · after-effects 2-8h Intravenous duration: onset 2-10m · total 3-7h · after-effects 2-8h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Custom Units carry a single dose per route, so the full ranges live in the reference above. A route's suggested dose is the midpoint of its common range. Ranges are harm-reduction guidance, not a prescription.
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for 4-HO-MET? Let us know. Reports are reviewed by moderators — this is not posted publicly.