Beta test rollout. This site is in community QA — please send feature requests, bug reports and data corrections on the Feedback page or on GitHub.

Home
    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    4-Fluoropentedrone Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 4 corroborating sources
    • 3 ROAs with full dose ladders
    • duration data present
    • 29 combo interactions documented
    • classified Tentative
    • classified Research-chemical

    Aliases: 4-fpd, 4-f-pentedrone, 4-fluoro-alpha-methylamino-valerophenone, 4f-pentedrone

    Stimulant Research-chemical

    Summary dose.wiki TripSit

    4-Fluoropentedrone (4-FPD) is a synthetic cathinone sold on the gray market since approximately 2018. Human pharmacology remains largely uncharacterised; harm-reduction advice is extrapolated from pentedrone and 4-FMC data plus limited community reports. Acute risks include tachycardia, hypertension, vasoconstriction, hyperthermia, diaphoresis, agitation, bruxism, mydriasis, anxiety, and panic.

    Dose Information Drugs.Wiki

    Dose basis. Oral: Ranges are extrapolated from closely related cathinones and limited user reports; potency and salt form (usually HCl) can markedly change the effective dose. Start with an allergy test (1–2 mg) and a very small test dose (5–10 mg), then wait a full 2–3 h before considering more. Evidence quality: anecdotal/harm-reduction orgs. Insufflated: Intranasal use increases cardiovascular spikes and nasal injury. Finely crush, use your own clean straw, and rinse with 0.9% saline before/after; rotate nostrils and take breaks. Evidence: harm-reduction org guidance on snorting risks. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Oral 20-40mg 40-80mg 80-120mg 120mg+
    Insufflated 10-25mg 25-60mg 60-90mg 90mg+
    Rectal 15-30mg 30-60mg 60-90mg 90mg+
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — Drugs.Wiki

    Insufflated

    Dose ladder — Drugs.Wiki

    Rectal

    Dose ladder — Drugs.Wiki

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 10-30 min 15-30 min 1-2 hrs 1-2 hrs 2-6 hrs 2.42-5 hrs
    Insufflated 2-5 min 5-10 min 1-2 hrs 1-2 hrs 2-6 hrs 2.11-4.25 hrs
    Rectal 5-10 min 10-20 min 1-2 hrs 1-2 hrs 2-6 hrs 2.25-4.5 hrs

    Effect Profile

    Scores (0–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 4.6
    Moderate+ 5/10

    Moderate euphoria and focus with strong anxiety/jitters, low stimulation

    Stimulation / Energy ×3
    3
    stimulation
    Euphoria / Mood Lift ×2
    7
    physical euphoria cognitive euphoria motivation enhancement
    Focus / Productivity ×2
    7
    focus enhancement motivation enhancement thought acceleration
    ⚠ Anxiety / Jitters ×1
    10
    anxiety paranoia increased heart rate bruxism vasoconstriction
    View methodology →

    Tolerance

    Build-up develops rapidly, often within a single session; compulsive redosing common
    Reset a few days for acute tolerance

    Tolerance Decay

    Full tolerance 1d Half tolerance 3d Baseline ~7d

    Anecdotal patterns suggest rapid tolerance with binge/redosing across 1–2 days, partial decay over 3–7 days, and near‑baseline by ~2 weeks. Data quality is low and varies widely among individuals.

    Cross-Tolerances

    Other cathinones
    Amphetamines
    Cocaine

    Effects dose.wiki

    Positive
    Negative
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral

    Combinations

    Cross-Check 4-Fluoropentedrone with another substance

    4-Fluoropentedrone's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📖 dose.wiki
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 4-Fluoropentedrone there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "4-Fluoropentedrone (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    4-Fluoropentedrone
    Unit
    mg
    Description 
    4-Fluoropentedrone
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 10-20 · light 20-40 · common 40-80 · strong 80-120 · heavy 120+
Insufflated dose (mg): threshold 5-10 · light 10-25 · common 25-60 · strong 60-90 · heavy 90+
Rectal dose (mg): threshold 8-15 · light 15-30 · common 30-60 · strong 60-90 · heavy 90+

Oral duration: onset 10-30m · come-up 15-30m · peak 1-2h · offset 1-2h · total 2.42-5h · after-effects 2-6h
Insufflated duration: onset 2-5m · come-up 5-10m · peak 1-2h · offset 1-2h · total 2.11-4.25h · after-effects 2-6h
Rectal duration: onset 5-10m · come-up 10-20m · peak 1-2h · offset 1-2h · total 2.25-4.5h · after-effects 2-6h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 60 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.