- Abnormal heartbeat
- Anxiety
- Appetite suppression
- Bronchodilation
- Cognitive euphoria
- Cognitive fatigue
- Compulsive redosing
- Dehydration
- Depression
- Disinhibition
- Ego inflation
- Focus enhancement
- Increased blood pressure
- Increased heart rate
- Increased libido
- Increased perspiration
- Irritability
- Motivation enhancement
- Pain relief
- Stimulation
- Teeth grinding
- Temporary erectile dysfunction
- Thought acceleration
- Thought deceleration
- Thought organization
- Vasoconstriction
- Wakefulness
Cocaine
Aliases: coke
Categories
Summary
A highly popular, short acting CNS stimulant that works by blocking the reuptake of dopamine, serotonin, and norepinephrine. It is known to increase euphoria, confidence, sex-drive, focus, body temperature, and heart rate. Cocaine can cause severe vasoconstriction and is known to be cardiotoxic and have a high potential for compulsive redosing and addiction.
Dose Information
Onset, Duration & After-effects
- Duration: 1-1.5 hours
- After-effects: 1-4 hours
Effects
- Elevated mood
- Increase in irritability
- hyper-inflated ego
- euphoria
- stimulation
- raised heartrate
- numbing effects depending on ROA
- nausea (particularly at high doses)
Helpful Links
Known Combinations
These combinations are considered extremely harmful and should always be avoided.
maois: This combination is poorly explored
opioids: Stimulants increase respiration rate allowing for a higher dose of opiates than normal. If the stimulant wears off first then the opiate may overcome the individual and cause respiratory arrest.
tramadol: Tramadol and stimulants both increase the risk of seizures.
There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.
2c-t-x: Cocaine and 2c-t-x both provide considerable stimulation. When combined they can result in severe vasoconstriction, tachycardia, hypertension, and in extreme cases heart failure.
5-meo-xxt: The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics.
alcohol: Cocaine can decrease some of the intoxicating effects of alcohol, causing some people to drink more than they otherwise would, which leads to greater behavioral and physical health risks. There is also some debate about cocaethylene, a metabolite produced when combining alcohol and cocaine, with some researchers positing that it is more cardiotoxic than cocaine on its own. Use moderation when combining these substances.
dextromethorphan: Both substances raise heart rate, in extreme cases, panic attacks caused by these drugs have led to more serious heart issues
dox: The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of cocaine can easily lead to thought loops. Coming down from cocaine while the DOx is still active can be quite anxiogenic
nbomes: Cocaine and NBOMes both provide considerable stimulation. When combined they can result in severe vasoconstriction, tachycardia, hypertension, and in extreme cases heart failure.
pcp: This combination can easily lead to hypermanic states
These combinations are not usually physically harmful, but may produce undesirable effects.
2c-x: The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable.
amphetamines: This combination of stimulants will increase strain on the heart. It is not generally worth it as cocaine has a mild blocking effect on dopamine releasers like amphetamine
caffeine: Both stimulants, risk of tachycardia, hypertension, and in extreme cases heart failure.
cannabis: Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
dmt: Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
ghb/gbl: Stimulants increase respiration rate allowing for a higher dose of sedatives than normal. If the stimulant wears off first the opiate may overcome the individual and cause respiratory arrest. Likewise the ghb/gbl can wear off and leave a dangerous concentration of cocaine behind
ketamine: No unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this combination may be ill advised due to risk of physical injury.
lsd: Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
mdma: Cocaine blocks some of the desirable effects of MDMA while increasing the risk of heart attack.
mescaline: The focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops
mushrooms: Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
mxe: Stimulants taken with MXE can lead to hypermanic states much more easily, especially if sleep is avoided.
Effects are additive. The combination is unlikely to cause any adverse or undesirable reaction.
ssris: May reduce each others' effectiveness. Cocaine can reduce mental stability and therefore exacerbate conditions which SSRIs are used to treat.
Effects are subtractive. The combination is unlikely to cause any adverse or undesirable reaction.
lithium: Lithium may inhibit some of the recreational effects of cocaine.
Studies
- Rhabdomyolysis associated with cocaine abuse.
- Rhabdomyolysis associated with cocaine abuse.
- The beta-lactam antibiotic ceftriaxone inhibits physical dependence and abstinence-induced withdrawal from cocaine, amphetamine, methamphetamine, a...
- Effects of concurrent use of alcohol and cocaine.
- Cocaine-like neurochemical effects of antihistaminic medications.
- Cocaine cardiotoxicity: a review of the pathophysiology, pathology, and treatment options.
- Citalopram enhances cocaine's subjective effects in rats.
- Role of voltage-gated sodium, potassium and calcium channels in the development of cocaine-associated cardiac arrhythmias.
- High cocaine dosage decreases neurogenesis in the hippocampus and impairs working memory.
- The effects of combinations of intranasal cocaine, smoked marijuana, and task performance on heart rate and blood pressure.
- Lack of cocaine-like discriminative-stimulus effects of σ-receptor agonists in rats.
- Pregabalin reduces cocaine self-administration and relapse to cocaine seeking in the rat.
- Cocaine potentiates MDMA-induced oxidative stress but not dopaminergic neurotoxicity in mice: implications for the pathogenesis of free radical-ind...
- Effects of escitalopram on attentional bias to cocaine-related stimuli and inhibitory control in cocaine-dependent subjects.
- Aminorex, a metabolite of the cocaine adulterant levamisole, exerts amphetamine like actions at monoamine transporters.
- Long Withdrawal of Methylphenidate Induces a Differential Response of the Dopaminergic System and Increases Sensitivity to Cocaine in the Prefronta...
- Cocaine tolerance and cross-tolerance.
- Cocaethylene is as cardiotoxic as cocaine but is less toxic than cocaine plus ethanol.
- Differential potentiation of L-tryptophan-induced head-twitch response in mice by cocaine and sertraline.
- Cocaine contamination of United States paper currency.
- A study suggests that having a history of cocaine and poly drug abuse can lead to acute open-angle glaucoma
- using cocaine while pregnant is dangerous for the fetus's health