4-AcO-DMT Well-documented

Well-documented

Multiple authoritative sources agree on dosing and effects.

6 corroborating sources

2 ROAs with full dose ladders

duration data present

30 combo interactions documented

toxicity data (PsychonautWiki)

classified Research-chemical

Aliases: 4-aco, Psilacetin, 4-acetoxy-dmt, O-acetylpsilocin, Synthetic mushrooms, 4acodmt

Summary dose.wiki Erowid TripSit PsychonautWiki

4-AcO-DMT is a synthetic psychedelic that rapidly converts to psilocin in the body, producing effects nearly identical to psilocybin mushrooms but with reportedly less nausea and body load. Effects are highly dose-dependent and can range from gentle mushroom-like experiences at low-moderate doses to intense DMT-like states at higher doses. Not recommended for individuals with personal or family history of psychosis.

Perspectives

“Beautiful life changing trip. Cannot articulate how beautiful it was. Not very visual or extremely strong, maybe due to the tolerance I built up. The lessons I thought I learned would end up not sticking, as nothing ever does. It turns out I am much less in control of things than I had thought.”

— Nervewing, nervewing.blogspot.com ~25–30 mg oral

“It was a pleasant ride, despite my poor condition. I look forward to further experimentation and perhaps a deeper and more spiritually meaningful trip.”

— Dominic Milton Trott, The Drug Users Bible 6 mg oral

Dose Information source varies by route

ROA	Light	Common	Strong	Heavy
Oral	5-15mg	15-25mg	25-40mg	40mg+
Insufflated	10-15mg	15-25mg	25-50mg	50mg+

Light Common Strong Heavy

Sources

Oral

Dose ladder — dose.wiki

Insufflated

Dose ladder — PsychonautWiki

Onset, Duration & After-effects dose.wiki TripSit PsychonautWiki

ROA	Onset	Comeup	Peak	Offset	After Effects	Total
Oral	19-60 min	30-90 min	2-3 hrs	1-2 hrs	2-8 hrs	6-8 hrs
Insufflated	1-15 min	15-30 min	1.5-3 hrs	1-2 hrs	2-6 hrs	3-5 hrs

Effect Profile

201 reports

Scores (0–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Validated against 127 Erowid trip reports
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Psychedelic 8.8

Intense+ 9/10

Strong visuals, headspace, and auditory effects with strong body load

Visual Intensity ×3

external hallucinations internal hallucinations colour enhancement autonomous entities tracers synaesthesia +10 more

Headspace Depth ×3

conceptual thinking thought connectivity personal meaning enhancement feelings of interdependent opposites subconscious communication multiple thought streams +9 more

Auditory Effects ×1

auditory distortion auditory enhancement auditory hallucinations auditory hallucination synaesthesia

⚠ Body Load / Somatic Effects ×1

nausea temperature regulation suppression teeth grinding

Based on reports from:

Effect Index My Triumphant Return Effect Index My One Bad Trip Effect Index Surrender Effect Index Relationship Problems Effect Index Extremely Reckless Drug Abuse with My Girlfriend

Tolerance

Build-up develops rapidly after a single use

Reset 7–14 days for baseline

Tolerance Decay

Full tolerance 1d Half tolerance 5d Baseline ~14d

Empirical rules of thumb from community data: substantial tolerance is present for several days after a dose; near‑baseline returns in roughly 10–14 days. Repeated redosing within a session provides diminishing returns and more side‑effects. Data quality is anecdotal; no controlled human tolerance studies for 4‑AcO‑DMT specifically.

Cross-Tolerances

Psilocybin/Psilocin

LSD & other serotonergic psychedelics

Effects Erowid Bluelight

Aggregated from 127 single-substance Erowid and 74 Bluelight experience reports (the Bluelight figures come from the 50 of them read for effects); 148 Erowid reports where another drug was taken too are left out

Each bar shows the share of analyzed reports whose text mentions that effect — a mention is not always a first-hand experience (fear of an effect or something witnessed can count). Mentions saying the effect did not happen are left out; that check reads keywords, so it can miss some. The shaded band on a bar, and the small range after its number, is the 95% interval: where the share could plausibly be with other reports of the same kind. Fewer reports, wider band. Tap or hover any number for details. The second value is the Bluelight extractor's per-effect confidence; a dash means the row is Erowid-derived, which has no confidence measurement.

Positive Effects 74

61.6% 82%

48.0% 87%

41.3% 91%

39.0% 86%

37.3% 88%

30.5% 90%

26.0% 87%

25.4% 87%

24.0% 89%

22.0% 88%

20.3% 85%

19.2% 85%

18.0% 89%

18.0% 81%

18.0% 87%

16.9% 86%

16.0% 86%

16.0% 89%

16.0% 87%

16.0% 81%

Show 54 more positive effects

14.0% 80%

13.0% 75%

12.0% 87%

10.2% 82%

10.0% 90%

10.0% 87%

10.0% 85%

10.0% 83%

10.0% 88%

8.0% 90%

8.0% 80%

8.0% 79%

8.0% 84%

8.0% 86%

8.0% 85%

6.0% 87%

6.0% 83%

6.0% 87%

4.0% 78%

4.0% 85%

4.0% 75%

4.0% 82%

4.0% 85%

4.0% 92%

4.0% 78%

4.0% 90%

4.0% 88%

3.4% 90%

2.0% 75%

2.0% 90%

2.0% 85%

2.0% 90%

2.0% 85%

2.0% 80%

2.0% 90%

2.0% 85%

2.0% 90%

2.0% 80%

2.0% 90%

2.0% 75%

2.0% 85%

2.0% 90%

2.0% 95%

2.0% 90%

2.0% 85%

2.0% 90%

2.0% 75%

Adverse Effects 45

52.0% 86%

36.2% 86%

28.8% 82%

22.0% 76%

16.0% 81%

12.4% 81%

12.4% 76%

12.0% 90%

11.8% –

10.0% 88%

10.0% 81%

10.0% 77%

8.7% –

8.0% 80%

8.0% 78%

8.0% 84%

7.9% –

7.1% –

6.0% 77%

6.0% 87%

Show 25 more adverse effects

4.0% 88%

4.0% 80%

4.0% 90%

4.0% 82%

4.0% 85%

4.0% 72%

4.0% 88%

2.0% 80%

2.0% 85%

2.0% 75%

2.0% 80%

2.0% 75%

2.0% 80%

2.0% 75%

2.0% 85%

2.0% 80%

2.0% 75%

2.0% 85%

2.0% 70%

2.0% 80%

2.0% 90%

2.0% 85%

2.0% 95%

Also reported in combinations. In the 148 4-AcO-DMT reports where another drug was taken too, 14 (9.5%) mention hospital, emergency services or an overdose, 5 (3.4%) a seizure and 11 (7.4%) psychosis. In the 127 single-substance reports: 12.6%, 0.8% and 8.7%. These are not in the figures above: they cannot be put down to 4-AcO-DMT alone, and a mention is not always something that happened to the writer.

Combinations

Cross-Check 4-AcO-DMT with another substance

Trip Reports Effect Index

My Triumphant Return Greg My One Bad Trip Greg Surrender Kaylee Relationship Problems Oscarette Extremely Reckless Drug Abuse with My Girlfriend Oscarette

Community Trip Reports

Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.

Reddit 8 reports 3 positive 4 neutral 1 cautionary visit

First Time Experience Last Night - Life Changing Clarity positive r/4acodmt ▲28 7 comments

I’ve been working through some serious issues with my wife. Basically the last year has been a living hell for the 2 of us as I have tried to finally deal with some parts of our faraway past that have included infidelity and betrayal.

25mg of Pure Awesome positive r/4acodmt ▲23 5 comments

Had an amazing experience on 25 mg of 4 ACO DMT yesterday. Are about one handful of nuts and a few slices of cheddar cheese, two hours before hand. Took the psilacetin with a big glass of magnesium citrate, the natural calm brand.

Vaped freebase neutral r/4acodmt ▲21 12 comments

This is beyond DMT, any ayahuascha, mescaline, 5-meo-DMT ANYTHING. Preface I took 22mg metocin about 2 hours ago. 1 hour in I added a Nn,DMT hoot which was fun for a half hour because the metocin wasnt doing much. Then I remembered I had 4-aco-DMT freebase.

55mg trip report neutral r/4acodmt ▲20 10 comments

I took 50-55mg of 4-aco-dmt yesterday. Previous trips have been 20mg (first time 13 months ago) and 30mg 8 months ago, so I really took a big step up, I wanted the full psychedelic experience which I feel has eluded me for the most part.

100mg trip report 🤯 positive r/4acodmt ▲18 2 comments

100mg (a little bit more actually, perhaps closer to 110mg) is too fucking much to take! I don't know what I was thinking. My previous highest dose was 50-55 mg, so why I doubled it up is beyond me. What a dope I am.

Has anyone else "broken through" on 4aco-dmt? neutral r/4acodmt ▲18 30 comments

I haven't talked about this with many people and not found a community like this, so I'm sorry if this is common knowledge. On 4aco dmt, my trip started with me suddenly feeling that I was curled up on the top of some stairs.

Well, that was kind of intense. neutral r/4acodmt ▲15 31 comments

So last night I tried 4-aco-dmt for the first time, I had 60mg fumarate and I dropped it all not knowing how high of a dose that would be. I had a pretty intense experience, a lot of visuals and scenarios it felt way more intense than mushrooms, but there's one thing in particula...

Accidentally doing a heroic dose of 4ACO felt like when Gandalf fought Balrog and died and resurrected and lived 1000 lifetimes in mere days of human time. cautionary r/4acodmt ▲16 6 comments

My old room mate left me a bag of 4ACO when he went to Europe, accompanied with the advice “please be careful”. IDK how much we actually did, but while drunk me and a friend dosed ourselves using a gram scale, then stupidly did a little bit more via finger dipping.

Erowid 8 reports 4 positive 4 cautionary visit

Trapped Behind Dissolving Eyes cautionary exp #84044

Three months separated me from the most trying time in my short history as a person. I had returned home had been rescued, rather, by my family after destroying my life, job, and friendships with my addictions to cocaine and heroin, and was living with my parents for the first time in over two years.

Plugging the Magic Ice Cube positive exp #114684

Plugging the Magic Ice Cube T0 4-AcO-DMT fumarate 22.5 mg rectal T+5h Melatonin 4mg oral (daily) Background: I am a moderate psychedelic drugs user for about 10 years, almost 30 years old now and I weight approx. 70kg for 1m81.

Perfect Weekend positive exp #101385

I dont normally do trip reports but the scope of my most recent experience was pretty interesting so I decided to attempt to put it in words that made sense. This experience wasn't a breakthrough of any kind but more of a string of insightful thoughts and beautiful colors to assist in the mood setting.

Solipsism Empathy and Halloween positive exp #105870

Substances: Time Dosage ROA Substance T-02:00 (repeated) oral Alcohol T 00:00 20mg oral 4-AcO-DMT ?? (repeated) smoked Cannabis Participants: MrHH [1988 +/- 54kg], D [1985 +/- 58kg], P [1985 +/- 58kg] Date: 19/oct/2014 Place: P's house Written by: MrHH Antecedents/Additional notes: + Substance has been analyzed through...

The Infinity of Existence positive exp #113623

[Erowid Note: Two samples of powder (even of the same chemical) with equivalent volumes won't necessarily weigh the same. For this reason, eyeballing is an inaccurate and potentially dangerous method of measuring, particularly for substances that are active in very small amounts.

Redlining the Tactile Engine cautionary exp #110441

[Erowid Note: The dose described in this report is very high, potentially beyond Erowid's 'heavy' range, and could pose serious health risks or result in unwanted, extreme effects.

Brutal Caveman Wasteland cautionary exp #110776

[Erowid Note: The dose described in this report is very high, potentially beyond Erowid's 'heavy' range, and could pose serious health risks or result in unwanted, extreme effects. Sometimes extremely high doses reported are errors rather than actual doses used.] Well, at least I'm laughing now.

The Seams of the Universe cautionary exp #86651

*Note: I don't recommend taking this high a dose and the only reason I do is for informational and research purposes.* [Erowid Note: The dose described in this report is very high, potentially beyond Erowid's 'heavy' range, and could pose serious health risks or result in unwanted, extreme effects.

Bluelight 5 threads 3 positive 2 neutral visit

4 Aco Malt 100 Mg Fourth Time Luxurious Probably Says It Best positive

The following Greek letters have been changed to protect the innocent. This trip report is written by Kappa. This was our fourth time taking 4-AcO-MALT, our first three times being at 25, 50, and 75 mg, and this one finally being our push to 100 mg.

4 Aco Malt 50 Mg Second Time Found It neutral

This was my second experience with 4-AcO-MALT. My first experience was not too long before this, but it had only produced generally mild effects, so I decided to double the dose and try again.

Psilacetin Experienced Untitled Rough Draft positive

September 4th, 2010 12mg of 4-acetoxy-N,N-dimethyltryptamine (psilacetin) via IM injection Introduction: Life is strange and different for me these days. I have been in a serious relationship of one form or another since I was 17, and living with a woman since I was 19.

4 Aco Malt 25 Mg First Time Promising Sensory Pleasures positive

This was my first experience with 4-AcO-MALT, and though it was light enough that I probably wouldn't have even written a report normally, I figured it was worth writing this up given that this is a brand new molecule, with to my knowledge nothing written on it yet.

4acodmt 20mg Beginner Perfect Weekend neutral

Hey all just wanted to say hello and I'm looking forward to contributing to the site. Recently I have felt all sorts of changes in my mind which led me to psychedelic research.

Dose.wiki 9 reports 3 positive 5 neutral 1 cautionary visit

A profound sense of oneness 20mg oral positive

I took 20mg of 4-aco-dmt with my tea in the bath tub of my apartment alone. Looking to pass the time in the bath, I decided to shave, but the nausea kicked in sooner than I thought and it was pretty difficult. During the nausea, I began getting weird thoughts…

A Relaxing Morning in the Park 30mg oral neutral

I had the day off work, it was a lovely day, so I had an early trip in the park by myself. I thought I would start off by watching some pornography, but it looked so fake that I lost all interest in it. I was listening to some music as well, and the actors’…

I begged the shroom aliens to kill me 26mg oral neutral

I took 26mg of 4-aco-dmt alone in my bedroom at 8pm. In 20 minutes, I was extremely nauseous. I wanted to throw up badly, but I held it in uncomfortably because I didn’t want to throw up the drug before I was sure it was absorbed. I turned off all the lights…

I saw an angry god-like figure made of clouds glaring down at me 20mg oral neutral

I grabbed a bottle of water, put earbuds in, turned on my ipod, smoked hash oil, swallowed 20mg of 4-aco-dmt, and walked outside. The setting was a beautiful sunny day with a temperature of around 80 degrees. I spent the beginning of my trip walking along…

I was overcome with feelings about my family 20mg insufflated neutral

Permanent all-encompassing states of unity and interconnectedness 20mg insufflated neutral

This truth has changed my life and it was the most powerful thing I had experienced at the time.. Almost a year later, I still see everyone as myself. You are me and I am you. I experience frission/asmr and whenever I read something that has to do with unity…

Thawing 25-30 mg oral in solution positive

Beautiful life changing trip. Cannot articulate how beautiful it was. Not very visual or extremely strong, maybe due to the tolerance I built up. The lessons I thought I learned would end up not sticking, as nothing ever does. It turns out I am much less in…

The Blizzard 25 mg oral in solution positive

I get off a bus that slowly and haphazardly travels through the snowy streets. There was a man on the bus, his face was covered in blood and he was throwing up on the floor. I walk towards the art museum from city hall taking swigs of my bottle as I go. I…

This is disgusting and shameful ~50mg oral in solution cautionary

I flavor the nasty blackish water and down it all in one gut wrenching gulp. First I taste the flavoring agent I added, then the metallic mildew flavor, and lastly a lasting chemical bitterness that resembles the flavor of the original chemical. I have to…

Bluelight Reference Guide Bluelight

Tryptamines The Big & Dandy 4-AcO-DMT Thread - Act Five

Welcome to the Big & Dandy 4-AcO-DMT Thread Psilacetin / 4-AcO-N,N-DMT / 4-Acetoxy-DMT / O-Acetyl-Psilocin iupac = 3-[2-(Dimethylamino)ethyl]-1H-indol-4-yl acetate External links: Erowid: Erowid 4-AcO-DMT Vault Trip Reports Wikipedia 4-Aco-DMT TIHKAL 4-AcO-DMT Entry Subthreads: First Time Dosage & Methods of Administra...

Read full thread on Bluelight →

4-AcO-DMT's nerd page Pharmacology, chemical data, effect profiles, and more

→

Helpful Links

📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki 📖 Bluelight 📖 The Drug Users Bible

Import into PsychonautWiki Journal

The PsychonautWiki Journal app includes 4-AcO-DMT, but its built-in data can be thinner than ours. Importing this file adds a separate "4-AcO-DMT (Substance Search)" custom substance with our dose ranges, durations and tolerance, so you can log against whichever you prefer.

⬇ Download import file Import this file as custom substances and you get "4-AcO-DMT (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer.

Ranges are harm-reduction guidance, not a prescription.

Report an issue or suggest an edit

Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for 4-AcO-DMT? Let us know. Reports are reviewed by moderators — this is not posted publicly.

4-AcO-DMT Well-documented Well-documented Multiple authoritative sources agree on dosing and effects. 6 corroborating sources 2 ROAs with full dose ladders duration data present 30 combo interactions documented toxicity data (PsychonautWiki) classified Research-chemical

Summary dose.wiki Erowid TripSit PsychonautWiki

Perspectives

Dose Information source varies by route

Oral

Insufflated

Onset, Duration & After-effects dose.wiki TripSit PsychonautWiki

Effect Profile

Tolerance

Tolerance Decay

Cross-Tolerances

Effects Erowid Bluelight

Positive Effects 74

Adverse Effects 45

Combinations

Trip Reports Effect Index

Community Trip Reports

Bluelight Reference Guide Bluelight

Tryptamines The Big & Dandy 4-AcO-DMT Thread - Act Five

Helpful Links

Report an issue or suggest an edit

4-AcO-DMT Well-documented

Well-documented

Multiple authoritative sources agree on dosing and effects.

6 corroborating sources

2 ROAs with full dose ladders

duration data present

30 combo interactions documented

toxicity data (PsychonautWiki)

classified Research-chemical