Note: This was the highest dose of the substance I've done up until this point. Last experience was 4 days previous that was fun but uneventful. Previous to that the last dose was 3 months prior, so any tolerance issues should've been minimal.
3-HO-PCE
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 6 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 29 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Tentative
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 6 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 29 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Tentative
- classified Research-chemical
Aliases: 3-oh-pce, 3-hydroxy pce, Hydroxyeticyclidine, 3hopce
Summary
3-Hydroxyeticyclidine (commonly known as 3-HO-PCE) is a novel synthetic dissociative substance of the arylcyclohexylamine chemical class. It produces potent, dose-sensitive dissociative, hallucinogenic and euphoric effects when administered. Unlike its close structural analog 3-HO-PCP, this compound has no precedent in the scientific literature before being offered on the research chemicals market in the 2010s.
Perspectives
“With a newer and better batch, 3-HO-PCE has truly shown itself as a powerful and remarkable dissociative. It is too sedating and inhibitory for my preferences nonetheless, though now that I have more thoroughly felt the substance out I can absolutely understand how others might enjoy this, as opposed to my total dismissal of it before.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 2-5mg | 5-10mg | 10-15mg | 15mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 19-45 min | 30-60 min | 1-3 hrs | 2-3 hrs | 3-4 hrs |
| Insufflated | 4-15 min | 15-30 min | 1-3 hrs | 2-3 hrs | 3-4 hrs |
Effect Profile
1 reportsScores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Dissociative
6.4
Strong
6/10
Strong dissociative depth with strong mania, moderate motor impairment and insight
Dissociative Depth
×3
10
depersonalization
derealization
physical disconnection
cognitive disconnection
visual disconnection
physical autonomy
+4 more
Mania / Compulsion
×1
10
mania
compulsive redosing
disinhibition
stimulation
Insight / Novel Thought
×2
6
conceptual thinking
analysis enhancement
perspective distortions
Motor / Sensory Impairment
×1
7
physical disconnection
tactile suppression
spatial disorientation
visual disconnection
Based on reports from:
Tolerance
Build-up
develops with repeated use over days to weeks
Reset
2–4 weeks for noticeable reduction
Tolerance Decay
Full tolerance
3d
Half tolerance
7d
Baseline
~28d
Modeled on typical arylcyclohexylamine patterns: rapid within‑week build, week‑scale decay. Data quality mostly anecdotal; adjust conservatively.
Cross-Tolerances
Effects
Effect glossary — · full glossary
Positive
Negative
Positive
Negative
Positive
Negative
Combinations
Cross-Check 3-HO-PCE with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 2 reports 1 positive 1 neutral visit
Preface: When 3-HO-PCE first became widely available in 2017 I picked up one of the first batches that hit the market. My experiences with this substance back then were lackluster, a barely discernible and odd empty mental dissociation that barely felt like a dissociative at all, but rather some other strange, neutral...
Dose.wiki 1 report 1 cautionary visit
This dissociative holds value for its novelty, though I did not find it particularly useful. The near total lack of physical effects was interesting, as was the all consuming cognitive dissociation. It was not physically stimulating, but was quite mentally…
Bluelight Reference Guide
☛ Official ☚ The Big & Dandy 3-HO-PCE Thread
A well known vendor will be releasing this soon, I was lucky enough to get a small sample I've only tried a few mg, so far my impressions are: more potent than 3-meo-pce/3-meo-pcp and more on the sedating side unlike the 3-meos fast onset duration is not as long as the 3-meos but that might just be the low doses
Read full thread on Bluelight →
3-HO-PCE's nerd page
Pharmacology, chemical data, effect profiles, and more
→
Helpful Links
Add missing routes to PsychonautWiki Journal
The PsychonautWiki Journal app already has 3-HO-PCE, but its built-in entry only covers Oral. Here are the other routes we have data for. You can't edit a built-in substance, but you can add a Custom Unit for any of these routes to log it.
⬇ Download import file
Import this file as custom substances
and you get "3-HO-PCE (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer. The manual values below work for older
versions.
Duration (reference)
3-HO-PCE: routes the PsychonautWiki Journal app is missing Source: SubstanceSearch (substancesearch.com) Insufflated duration: onset 4-15m · come-up 15-30m · peak 1-3h · offset 2-3h · total 3-4h · after-effects 1-4h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Ranges are harm-reduction guidance, not a prescription.
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for 3-HO-PCE? Let us know. Reports are reviewed by moderators — this is not posted publicly.