Let me start this off by saying this is a beautiful chemical. As with any other chemical treat it with respect and it will pay you back with consistent enjoyable effects. I started my research on this compound , 500ug sublingual For me, not much to write home about.
25B-NBOH
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 4 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 29 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Tentative
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 4 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 29 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Tentative
- classified Research-chemical
Aliases: Nboh-2c-b, 2c-b-nboh, 25bnboh, nboh-2cb, 2cb-nboh
Summary
25B-NBOH is a potent synthetic psychedelic that is often misrepresented as LSD in powder or blotter form. Due to its extreme potency and unpredictable dose-response, it poses significant health risks including seizures, vasoconstriction, hyperthermia, and acute kidney injury. Insufflation (snorting) is especially dangerous and has been linked to rapid-onset status epilepticus.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Buccal | 200-400ug | 400-800ug | 800ug-1mg | 1mg+ |
| Sublingual | 200-400ug | 400-800ug | 800ug-1mg | 1mg+ |
Light
Common
Strong
Heavy
Sources
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Buccal | 20-40 min | 30-60 min | 2-4 hrs | 2-6 hrs | 4-10 hrs |
| Sublingual | 20-40 min | - | 4-10 hrs | - | 4-10 hrs |
Effect Profile
4 reportsScores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
8.4
Intense
8/10
Strong visuals, auditory effects, and headspace with strong body load
Visual Intensity
×3
10
color enhancement
drifting
tracers
synaesthesia
pattern recognition enhancement
scenery slicing
+6 more
Headspace Depth
×3
9
conceptual thinking
recursion
emotion enhancement
personal bias suppression
time distortion
confusion
Auditory Effects
×1
10
auditory distortion
auditory hallucination
synaesthesia
Body Load / Somatic Effects
×1
10
vasoconstriction
temperature regulation suppression
nausea
muscle tension
increased heart rate
Based on reports from:
Tolerance
Build-up
develops rapidly after a single use
Reset
7โ14 days for baseline
Tolerance Decay
Full tolerance
12h
Half tolerance
7d
Baseline
~14d
Immediate acute tolerance develops after dosing; crossโtolerance with other 5โHT2A agonists is expected. Anecdotal reports suggest tolerance may persist ~1โ2 weeks depending on dose and individual variability. Data quality is limited and primarily anecdotal.
Cross-Tolerances
LSD/lysergamides
Other phenethylamine psychedelics (e.g., 2CโB/DOx)
Other NBOH/NBOMe
Effects
Aggregated from 4 single-substance Erowid experience reports; 2 Erowid reports where another drug was taken too are left out
Each bar shows the share of analyzed reports whose text mentions that effect — a mention is not always a first-hand experience (fear of an effect or something witnessed can count). Mentions saying the effect did not happen are left out; that check reads keywords, so it can miss some. The shaded band on a bar, and the small range after its number, is the 95% interval: where the share could plausibly be with other reports of the same kind. Fewer reports, wider band. Tap or hover any number for details. The second value is the Bluelight extractor's per-effect confidence; a dash means the row is Erowid-derived, which has no confidence measurement.
Too few reports for bars: these effects come from 4 single-substance Erowid reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?
Effect glossary — · full glossary
Positive Effects 4
4 of 4
–
4 of 4
–
3 of 4
–
3 of 4
–
Adverse Effects 1
3 of 4
–
Combinations
Cross-Check 25B-NBOH with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 4 reports 3 positive 1 neutral visit
Some background: Iยve tripped pretty heavily on literally dozens of psychedelics before this point, and am an experienced drug user on many accounts, but this compound still took me by surprise.
+0:00 100 micrograms 25b-nboh IV +0:05 We've reached peak visuals. The best way to describe this is one of those metal lawn ornaments that spins in the wind, usually in a butterfly or dragonfly shape that spins in the wind. Open eye, field of view is distorted into that.
Sensory Overload, a Phenomal Experience! I bought some 25B-NBOH and put it on blotters myself, each containing 500ug. I'm pretty excited about this substance because I expect it to be a bit like 2C-B given its chemical structure. 2C-B is one of my favorite substances.
25B-NBOH's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track 25B-NBOH there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
⬇ Download import file
Import this file as custom substances
and you get "25B-NBOH (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer. The manual values below work for older
versions.
Name
25B-NBOH
Unit
ยตg
Description
25B-NBOH Source: SubstanceSearch (substancesearch.com) Buccal dose (ยตg): threshold 200ug ยท light 200-400ug ยท common 400-800ug ยท strong 800ug-1mg ยท heavy 1mg+ Sublingual dose (ยตg): light 200-400ug ยท common 400-800ug ยท strong 800ug-1mg ยท heavy 1mg+ Buccal duration: onset 20-40m ยท come-up 0.5-1h ยท peak 2-4h ยท offset 2-6h ยท total 4-10h ยท after-effects 12h Sublingual duration: onset 20-40m ยท peak 4-10h ยท total 4-10h ยท after-effects 1-12h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 600 ยตg (Buccal).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
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