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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    2-MEC Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 29 combo interactions documented
    • classified Tentative
    • classified Research-chemical

    Aliases: Ortho-ethcathinone

    Stimulant Research-chemical

    Summary dose.wiki TripSit

    2-MEC appeared on grey-market outlets around 2012 as a mephedrone substitute, often in 'NRG-2' blends. Studies indicate 2-substituted cathinones are generally weaker than 3- or 4-substituted analogs due to steric hindrance. Users describe it as producing less empathogenic effects compared to mephedrone, with more prominent stimulation and cardiovascular strain.

    Dose Information TripSit

    ROA Light Common Strong Heavy
    Oral / Sublingual 50-100mg 100-200mg 200-350mg 350mg+
    Insufflated 25-50mg 50-100mg 100-250mg 250mg+
    Light Common Strong Heavy
    Sources

    Oral / Sublingual

    Dose ladder — TripSit

    Insufflated

    Dose ladder — dose.wiki, TripSit

    Onset, Duration & After-effects dose.wiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Oral / Sublingual 15-40 min 20-40 min 30-90 min 1-2 hrs 2-6 hrs 2.08-4.84 hrs
    Insufflated 5-10 min 10-20 min 30-90 min 1-2 hrs 2-6 hrs 1.75-4 hrs
    Rectal 10-20 min 15-30 min 30-90 min 1-2 hrs 2-6 hrs 1.92-4.33 hrs

    Effect Profile

    Scores (0–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Empathogen 5.0
    Moderate+ 5/10

    Moderate stimulation and sensory enhancement with mild empathy, low euphoria

    Empathy / Social Openness ×3
    5
    empathy enhancement increased sociability
    Euphoria / Mood Elevation ×2
    3
    euphoria
    Stimulation ×1
    7
    stimulation wakefulness teeth grinding increased heart rate
    Sensory Enhancement ×1
    7
    tactile enhancement color enhancement increased libido
    Stimulant 4.9
    Moderate+ 5/10

    Moderate focus with strong anxiety/jitters, mild stimulation and euphoria

    Stimulation / Energy ×3
    5
    stimulation wakefulness
    Euphoria / Mood Lift ×2
    5
    euphoria motivation enhancement
    Focus / Productivity ×2
    7
    focus enhancement thought acceleration motivation enhancement
    ⚠ Anxiety / Jitters ×1
    10
    anxiety teeth grinding increased heart rate jaw clenching vasoconstriction
    View methodology →

    Tolerance

    Build-up develops rapidly, often within a single session; compulsive redosing common
    Reset a few days for acute tolerance

    Tolerance Decay

    Full tolerance 6h Half tolerance 3d Baseline ~10d

    Acute within‑session tachyphylaxis is common with cathinones; repeated redosing produces diminishing returns and a harsher comedown. Cross‑tolerance with other monoaminergic stimulants/empathogens is expected based on mechanism overlap. Waiting at least 7–14 days between sessions reduces residual tolerance and mood after‑effects.

    Cross-Tolerances

    Mephedrone (4‑MMC)
    4‑MEC
    Other stimulant cathinones

    Effects dose.wiki

    Positive
    Negative
    Positive
    Negative
    Neutral
    Positive
    Negative

    Combinations

    Cross-Check 2-MEC with another substance

    2-MEC's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📖 dose.wiki
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 2-MEC there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "2-MEC (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    2-MEC
    Unit
    mg
    Description 
    2-MEC
Source: SubstanceSearch (substancesearch.com)

Oral / Sublingual dose (mg): threshold 25 · light 50-100 · common 100-200 · strong 200-350 · heavy 350+
Insufflated dose (mg): light 25-50 · common 50-100 · strong 100-250 · heavy 250+

Oral / Sublingual duration: onset 15-40m · come-up 20-40m · peak 0.5-1.5h · offset 1-2h · total 2.08-4.84h · after-effects 2-6h
Insufflated duration: onset 5-10m · come-up 10-20m · peak 0.5-1.5h · offset 1-2h · total 1.75-4h · after-effects 2-6h
Rectal duration: onset 10-20m · come-up 15-30m · peak 0.5-1.5h · offset 1-2h · total 1.92-4.33h · after-effects 2-6h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 150 mg (Oral / Sublingual).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.