4-MEC Well-documented

Well-documented

Multiple authoritative sources agree on dosing and effects.

4 corroborating sources

2 ROAs with full dose ladders

duration data present

29 combo interactions documented

classified Research-chemical

Aliases: Nrg-2, 4-methylethcathinone, 4mec

Summary dose.wiki Erowid TripSit

4-MEC is generally considered less potent than mephedrone, requiring approximately double the dose for comparable effects. It has a reputation for producing less intense euphoria but being more forgiving on the body. Intravenous use is particularly rough on veins and can cause vascular damage with chronic use.

Dose Information dose.wiki TripSit

ROA	Light	Common	Strong	Heavy
Oral	50-100mg	100-200mg	200mg+	-
Insufflated	25-40mg	40-100mg	100-150mg	150mg+

Light Common Strong Heavy

Sources

Oral

Dose ladder — dose.wiki, TripSit

Insufflated

Dose ladder — dose.wiki, TripSit

Onset, Duration & After-effects dose.wiki TripSit

ROA	Onset	Comeup	Peak	Offset	After Effects	Total
Oral	20-60 min	30-45 min	1-2 hrs	1-3 hrs	2-6 hrs	2.83-6.75 hrs
Insufflated	5-10 min	10-20 min	1-2 hrs	1-3 hrs	2-6 hrs	2.25-5.5 hrs
Intravenous	<1-1 min	1-2 min	20-30 min	1-2 hrs	2-6 hrs	1.35-2.55 hrs

Effect Profile

15 reports

Scores (0–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Empathogen 5.3

Moderate+ 5/10

Strong sensory enhancement with mild empathy, euphoria, and stimulation

Empathy / Social Openness ×3

empathy enhancement increased sociability

Euphoria / Mood Elevation ×2

euphoria mood lift

Stimulation ×1

stimulation teeth grinding

Sensory Enhancement ×1

tactile enhancement music enhancement increased libido

Stimulant 3.5

Moderate 4/10

Moderate euphoria with strong anxiety/jitters, low stimulation and focus

Stimulation / Energy ×3

stimulation

Euphoria / Mood Lift ×2

euphoria mood lift motivation enhancement

Focus / Productivity ×2

motivation enhancement

⚠ Anxiety / Jitters ×1

anxiety teeth grinding bruxism sweating

Based on reports from:

Erowid Experience Reports

Tolerance

Build-up develops rapidly, often within a single session; compulsive redosing common

Reset a few days for acute tolerance

Tolerance Decay

Full tolerance 1d Half tolerance 7d Baseline ~21d

Acute tolerance within a session is common; users report markedly diminished returns after initial doses and stronger comedowns with binges. Conservative spacing (≥2 weeks) is commonly advised in HR communities to limit cumulative harms; empirical pharmacodynamic tolerance half-life is not well established.

Cross-Tolerances

Other cathinones (e.g., 3‑MMC, 4‑MMC)

MDMA

Effects Erowid

Aggregated from 15 single-substance Erowid experience reports; 7 Erowid reports where another drug was taken too are left out

Each bar shows the share of analyzed reports whose text mentions that effect — a mention is not always a first-hand experience (fear of an effect or something witnessed can count). Mentions saying the effect did not happen are left out; that check reads keywords, so it can miss some. The shaded band on a bar, and the small range after its number, is the 95% interval: where the share could plausibly be with other reports of the same kind. Fewer reports, wider band. Tap or hover any number for details. The second value is the Bluelight extractor's per-effect confidence; a dash means the row is Erowid-derived, which has no confidence measurement.

Too few reports for bars: these effects come from 15 single-substance Erowid reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?

Positive Effects 5

12 of 15 –

9 of 15 –

6 of 15 –

5 of 15 –

4 of 15 –

Adverse Effects 6

6 of 15 –

5 of 15 –

4 of 15 –

3 of 15 –

Also reported in combinations. In the 7 4-MEC reports where another drug was taken too, 2 mention hospital, emergency services or an overdose, 0 a seizure and 0 psychosis (too few reports for percentages). In the 15 single-substance reports: 0, 0 and 0. These are not in the figures above: they cannot be put down to 4-MEC alone, and a mention is not always something that happened to the writer.

Combinations

Cross-Check 4-MEC with another substance

Community Trip Reports

Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.

Erowid 8 reports 3 positive 3 neutral 2 cautionary visit

Not a Positive Experience cautionary exp #91913

About me 39 years old male 310lbs and 6foot 3inches tall Past drug experience: ALCOHOL: Drinking alcohol to the point of puking / spins / knows what its like to feel slurring speech drunk / intense buzz of alcohol done via shots and repeated cocktails MDMA: Tried 1 500mg pill of pure MDMA once at age 23, literally cam...

Power and Speed cautionary exp #91335

Dose Schedule: 0:00 4-mec 2mg insufflated 0:10 4-mec 6mg insufflated 0:30 4-mec 6mg insufflated 1:00 Caffiene 70mg Oral 2:55 4-mec 3mg insufflated 3:45 4-mec 4mg insufflated 4:05 4-mec 4mg insufflated To start off this report, I would like to introduce the reader to the history of my drug use.

Psychological Dependency and Binges neutral exp #92333

I offer this in part as a corrective to my earlier experience report on this substance. Its been 3 days since my last and hopefully final binge on 4-MEC. I still have a little blood coming out of my congested nose when I blow, but the congestion and cold symptoms are finally easing off, and my mood swings have become t...

In Between Cocaine and MDMA positive exp #94597

After reading online for quite some time about various cathinones/MDxx replacements, I decided to try my hand at 4-MEC after seeing a research chemical vendor offering it for an insanely low price. So it was, I ordered 2 grams of the substance.

Reminiscent of Ritalin neutral exp #97219

We discovered 4-MEC when browsing a certain research chemical vendor's catalog. After reading some reports me and three friends decided that 4-MEC was worth the experiment, and so we bought three grams total and shared the compound between the four of us was going to be a very peculiar evening.

Most of What You Need to Know positive exp #99725

I've taken a whole lot of drugs, the only ones that would pertain to this trip report would be 6-APB, stims like methylphenidate and adderal, cocaine and dozens of $5 street ecstasy pills ranging from good to real shitty. I've had my share of 'rolls', just never had real MDMA.

A Rush of Pure Bliss Then I Need More positive exp #91730

Im a 45-year old man, with a 30-year long history of use of psychoactive substances, including most or all of the major psychedelics and stimulants, some dissociatives, and limited numbers of opiates, benzos, etc.

Depressive Bliss neutral exp #92510

Recently, I ordered some MXE online. Knowing online vendors I was nowhere near surprised when I received 4-MEC instead of MXE. This drug was never of much interest to me; I know very little about its pharmacology, I typically do not like stimulant drugs, and I never saw any long lasting effects of this substance for th...

Bluelight 6 threads 2 positive 3 neutral 1 cautionary visit

4 Mec 120mg Perpetually Inexperienced Low Level Drugs positive

Hi, I'm an early 30s 75kgish male. I've done 4-MEC before in increasing doses, because I'm a (lol) responsible drugs user, from <1mg allergy test, 10mg, 50mg test doses.

4 Mec 830 Mg First Time Tried 830mgs Of 4 Methylethcathinone Done Over 4 Hours neutral

I am 39yo, 6-feet 3-inches tall and weigh 310lbs. I have never snorted any drug before trying 4-MEC today. I have not had alcohol or any other psychoactive substances in my system since december 2010. Received 4grams of 4-MEC / 4-Methylethcathinone from a good supplier; batch was very clean and close to pure.

Nrg 2 New Experience positive

Hi Guys I have spent a long time trying to find a trip reviews or even some good info on this drug but seems everywhere I look all I find is rubbish So a supplier who I have used for a long time with RC's and has allways supplied me with very good quality product has just got this into stock So I have ordered myslef 1g...

4 Mec 150mg Insufflated First Time Not What I Expected neutral

Substance: 2-(Ethylamino)-1-(4-methylphenyl)propan-1-one HCL or 4 MEC Purity: 99.80% Recent drug history: Mephedrone, Methylone, MDPV, MDMA, LSD, 2cb, 4-aco-dmt, MXE, 4-meo-pcp, Ketamine, Cocaine, GHB, GBL, 5-meo-mipt, 5-meo-dalt, aMT, 5-meo-dpt ( EDIT: Sorry to get you excited - this was indeed supposed to be 5-meo-di...

4 Mec Insufflated 10 10mg Session Naive Mixed Feelings But May Reconsider cautionary

Hello ! my very first trip report goes as following : Body Weight : 75 kg Previous experiences with stimulants : ephedrine, cocaine hcl, cocaine freebase (experienced) Others : codeine, morphine, buprenorphine, DXM, Methoxetamine (experienced) Psychedelics : sclerotia (one time), LSA seeds (one time) No substance use i...

4 Mec 1st Time 65mg neutral

4-CMC 1st time 65MG hello all this is my first trip report ever, so bear with me. Alright so i acquired some 4-CMC aka Clephedrone aka 4-chloromethcathinone (4-CMC) via sample. I have 1 gram. I am 6"1 tall 160 lbs decently healthy. I do have a opiate/opiod addiction i treat with kratom and a benzodiazepine habit.

4-MEC's nerd page Pharmacology, chemical data, effect profiles, and more

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Helpful Links

📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki

Add to PsychonautWiki Journal

The PsychonautWiki Journal logging app doesn't include every substance. To track 4-MEC there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

⬇ Download import file Import this file as custom substances and you get "4-MEC (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.

Name

4-MEC

Unit

Description

4-MEC
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): light 50-100 · common 100-200 · strong 200+
Insufflated dose (mg): light 25-40 · common 40-100 · strong 100-150 · heavy 150+

Oral duration: onset 0.33-1h · come-up 30-45m · peak 1-2h · offset 1-3h · total 2.83-6.75h · after-effects 2-6h
Insufflated duration: onset 5-10m · come-up 10-20m · peak 1-2h · offset 1-3h · total 2.25-5.5h · after-effects 2-6h
Intravenous duration: onset <1-1m · come-up 1-2m · peak 20-30m · offset 1-2h · total 1.35-2.55h · after-effects 2-6h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 150 mg (Oral).

The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

Report an issue or suggest an edit

Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for 4-MEC? Let us know. Reports are reviewed by moderators — this is not posted publicly.

4-MEC Well-documented Well-documented Multiple authoritative sources agree on dosing and effects. 4 corroborating sources 2 ROAs with full dose ladders duration data present 29 combo interactions documented classified Research-chemical