Beta test rollout. This site is in community QA — please send feature requests, bug reports and data corrections on the Feedback page or on GitHub.

Home
    Disclaimer
    Zolazepam molecular structure

    Zolazepam Stats & Data

    NPS DataHub
    MW286.31
    FormulaC15H15FN4O
    CAS31352-82-6
    IUPAC4-(2-fluorophenyl)-1,3,8-trimethyl-6H-pyrazolo[4,5-f][1,4]diazepin-7-one
    SMILESO=C1CN=C(c2ccccc2F)c2c(C)nn(C)c2N1C
    InChIKeyGDSCFOSHSOWNDL-UHFFFAOYSA-N
    Chemical Class Pyrazolodiazepinone
    Psychoactive Class Depressant

    Pharmacology

    DrugBank

    Description

    Zolazepam is a pyrazolodiazepinone derivative used as an anaesthetic in veterinary medicine. Zolazepam is typically used in combination with the NMDA antagonist tiletamine or the α2 adrenoceptor agonist xylazine. It is around four times the potency of diazepam but it is both water-soluble and un-ionized at physiological pH meaning that its onset is very fast.

    Tolerance & Pharmacokinetics

    drugs.wiki

    No tolerance chart. Our decay curves for these drugs were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.

    How fast tolerance to these drugs fades after a break has not been measured well enough to draw, so don't count on a dose you used to take still being safe: after time off, start with a much smaller amount and don't use alone. Mixing sedatives with each other, with alcohol or with opioids sharply raises the risk of a fatal overdose. If you've been using regularly, don't stop suddenly: withdrawal from benzodiazepines, alcohol or GHB/GBL can cause seizures or delirium, so get medical help to cut down gradually.

    Sources: FRANK: benzodiazepines · Alcohol and Drug Foundation: GHB · FDA 2020: benzodiazepine boxed warning · FDA 2019: gabapentinoids and breathing · NHS: alcohol use disorder

    Experience Report Analysis

    Erowid
    3 Reports
    0 Single-substance
    1997–2010 Date Range
    1 With Age Data

    Demographics

    Gender Distribution

    Too few reports for a chart: gender is known from 3 reports, and a split is drawn only from 20 reports or more. Counts are shown instead. Why 20?

    • Male 2 of 3
    • Not Specified 1 of 3

    Age Distribution

    Reports Over Time

    Common Combinations

    Most co-occurring substances, as a share of all 3 reports filed under Zolazepam

    Too few reports for bars: these combinations come from 3 reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?

    • Tiletamine 3 of 3

    Form / Preparation

    Most common forms and preparations, as a share of the 2 reports that give one

    Too few reports for bars: these forms come from 2 reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?

    • Liquid 2 of 2
    ← Back to Zolazepam