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    Tizanidine Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 1 source
    • 1 ROA with full dose ladder
    • duration data present
    • toxicity data (PsychonautWiki, PubChem)

    Aliases: Tizanidine hcl

    Depressant

    Summary PsychonautWiki

    Tizanidine (known by the trade names Zanaflex and Trinex among others) is a depressant substance of the imidazoline class closely related to clonidine. Tizanidine is primarily used primarily as an antispasmodic drug. Tizanidine's effectivness is similar to that of baclofen or diazepam .

    Dose Information dose.wiki PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 2-3mg 4-5mg 6-8mg 8mg+
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — dose.wiki, PsychonautWiki

    Onset, Duration & After-effects PsychonautWiki

    ROA Onset Peak
    Oral 12-48 min 1-2 hrs

    Tolerance

    Build-up develops over 1–4 weeks of regular use
    Reset days to weeks depending on duration of use

    Tolerance Decay

    Full tolerance 3d Half tolerance 8d Baseline ~14d

    Effects

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.

    Erowid 2 reports 2 cautionary visit
    Very Calming. Higher Dose Caused Visuals cautionary exp #114146

    Consumption: 2 pills on empty stomach. At other times ingested just before a meal. Times used the aforementioned ways: 4 to 6 times. Suggested dosage is one pill [prescribed for female weighing 155 pounds]. I take 2 pills (4mg each) to see what feeling I get. T+0.0- Average day. Average body feelings. Slightly tired.

    nineXape
    Not Worth It cautionary exp #118943

    Consumption: 3+1 pills on an empty stomach. Had 3 pills and 2 hours later took a 4th one. I quit doing drugs after a amazing LSA trip that changed the way I view many things in life, my relationship with my parents, my friendships, and the way I viewed drugs.

    Jan

    Pill Identifiers

    34 known pill identifiers on record — view imprints, colors, shapes, and images
    →
    Tizanidine's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 PsychonautWiki
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track Tizanidine there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "Tizanidine (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    Tizanidine
    Unit
    mg
    Description 
    Tizanidine
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): light 2-3 · common 4-5 · strong 6-8 · heavy 8+

Oral duration: onset 12-48m · peak 1-2h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 4.5 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.