First Experiments With THC-O-Acetate I have many years of experience with edibles and smoking/vaping D8 and D9 THC as well as various CBD derivatives. I've used Psilocybin mushrooms, LSD, and DMT many many times as well. I purchased a few THC-O-Acetate shots off an online hemp retail website.
THC-O-acetate
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 2 corroborating sources
- no dose data
- 27 combo interactions documented
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 2 corroborating sources
- no dose data
- 27 combo interactions documented
Summary
THC-O-acetate Legal status UK: Class B US: Unscheduled Identifiers IUPAC name (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-yl acetate CAS Number 23132-17-4 ☒ PubChem CID 198013 ChemSpider 171383 check UNII VHV54M2AES CompTox Dashboard (EPA) DTXSID30177698 Edit this at Wikidata Chemical and physical data Formula C23H32O3 Molar mass 356.506 g·mol−1 SMILES O=C(Oc2cc(cc1OC([C@@H]3CC/C(=C\[C@H]3c12)C)(C)C)CCCCC)C InChI InChI=1S/C23H32O3/c1-6-7-8-9-17-13-20(25-16(3)24)22-18-12-15(2)10-11-19(18)23(4,5)26-21(22)14-17/h12-14,18-19H,6-11H2,1-5H3/t18-,19-/m1/s1 check Key:DEWSJDIJFWQLOA-RTBURBONSA-N check THC acetate ester (THC-O-acetate, THC acetate, O-acetyl-Δ9-THC, THC-O, ATHC) is the acetate ester of THC. Physical data, chemistry & properties O-acetyl-Δ8-THC O-acetyl-Δ8-THC THC acetate ester can be synthesized from THC, or from THCA. The acetylation of THC does not change the properties of the compound to the same extent as with other acetate esters, as the parent compound (THC) is already highly lipophilic, but potency is nonetheless increased to some extent.
Tolerance
Build-up
develops over weeks of regular use via CB1 receptor downregulation
Reset
2–4 weeks for most users; heavy users may need longer
Tolerance Decay
Full tolerance
3d
Half tolerance
21d
Baseline
~28d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
Effect glossary — · full glossary
Positive
Negative
Positive
Negative
Positive
Negative
Combinations
Cross-Check THC-O-acetate with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 1 report 1 positive visit
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