Sufentanil
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 3 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 29 combo interactions documented
- toxicity data (PsychonautWiki, PubChem)
- 3 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 29 combo interactions documented
- toxicity data (PsychonautWiki, PubChem)
Aliases: Dsuvia, Sufenta, Chronogesic
Summary
Sufentanil, also known as sufentanyl and by the brand name Sufenta, is an extremely potent synthetic anilidopiperidine opioid analgesic. Sufentanil has a rapid onset and short mechanism and is used medically as an analgesic in surgical procedures or for the management of post-operative pain. Sufentanil is roughly 500 to 1,000 times more potent than pharmaceutical grade morphine and is approximately 10 times more potent than pharmaceutical grade fentanyl.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Intravenous | 1-5μg | 5-10μg | 10-25μg | 25μg+ |
Sources
Intravenous
Dose ladder — dose.wiki, PsychonautWikiOnset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Intravenous | 1-2 min | 5-10 min | 15-30 min | 21-42 min |
| Epidural | 5-15 min | 30-60 min | 1-2 hrs | 1.58-3.25 hrs |
| Sublingual | 10-30 min | 60-90 min | 1-2 hrs | 2.17-4 hrs |
Effect Profile
Scores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong euphoria and sedation with moderate itching/nausea, mild pain relief
Tolerance
No tolerance chart. Our decay curves for opioids were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.
Opioid tolerance drops fast when you stop, and even a few days off can be enough, so a dose that used to be normal can now stop your breathing. Overdose deaths rise sharply after prison, detox or leaving treatment, and tolerance also falls during a hospital stay. After any break, start with a much smaller amount, try a test dose first, don't use alone, and keep naloxone within reach. Alcohol, benzodiazepines, gabapentinoids and other sedatives make an opioid overdose much more likely.
Sources: FRANK: heroin · National Harm Reduction Coalition · WHO: opioid overdose · Merrall et al. 2010 · Binswanger et al. 2007 · Strang et al. 2003 · FDA 2019: gabapentinoids and breathing
Effects
Effect glossary — · full glossary
- Changes in focus
Combinations
Cross-Check Sufentanil with another substanceHelpful Links
Add missing routes to PsychonautWiki Journal
The PsychonautWiki Journal app already has Sufentanil, but its built-in entry only covers Intravenous. Here are the other routes we have data for. You can't edit a built-in substance, but you can add a Custom Unit for any of these routes to log it.
Sufentanil: routes the PsychonautWiki Journal app is missing Source: SubstanceSearch (substancesearch.com) Sublingual duration: onset 10-30m · peak 1-1.5h · offset 1-2h · total 2.17-4h · after-effects 2-8h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Ranges are harm-reduction guidance, not a prescription.
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for Sufentanil? Let us know. Reports are reviewed by moderators — this is not posted publicly.