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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Pyrophenidone Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 1 source
    • 2 ROAs with full dose ladders
    • duration data present
    • 29 combo interactions documented
    • classified Tentative
    • classified Research-chemical

    Stimulant Research-chemical

    Summary TripSit

    An NDRI pyrovalerone derivative reported to have very similar subjective effects. Virtually no information exists about this drug's effects in humans.

    Dose Information dose.wiki TripSit

    ROA Light Common Strong Heavy
    Insufflated 20-40mg 40-60mg 60-90mg 90mg+
    Vapourized 5-10mg 10-25mg 25-50mg 50mg+
    Light Common Strong Heavy
    Sources

    Insufflated

    Dose ladder — dose.wiki, TripSit

    Vapourized

    Dose ladder — dose.wiki, TripSit

    Onset, Duration & After-effects TripSit

    ROA Onset Peak After Effects
    Insufflated 5-15 min 1-3 hrs 1-3 hrs
    Vapourized 1-30 min 60-90 min 1-3 hrs

    Effect Profile

    class estimate

    Scores (0–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • No reports exist for this substance. Its effect list is the one shared by 2 other substances of the same class, so the scores below describe the class, not this compound.
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 3.8
    Moderate 4/10

    Moderate stimulation and euphoria with strong anxiety/jitters

    Stimulation / Energy ×3
    6
    stimulation wakefulness alertness enhancement
    Euphoria / Mood Lift ×2
    6
    euphoria cognitive euphoria
    Focus / Productivity ×2
    0
    ⚠ Anxiety / Jitters ×1
    10
    anxiety restlessness increased heart rate vasoconstriction
    View methodology →

    Tolerance

    Build-up develops rapidly, often within a single session; compulsive redosing common
    Reset a few days for acute tolerance

    Tolerance Decay

    Full tolerance 1h Half tolerance 4d Baseline ~5d

    Effects

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral

    Combinations TripSit

    Cross-Check Pyrophenidone with another substance

    Pyrophenidone's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📖 TripSit
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track Pyrophenidone there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "Pyrophenidone (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    Pyrophenidone
    Unit
    mg
    Description 
    Pyrophenidone
Source: SubstanceSearch (substancesearch.com)

Insufflated dose (mg): light 20-40 · common 40-60 · strong 60-90 · heavy 90+
Vapourized dose (mg): light 5-10 · common 10-25 · strong 25-50 · heavy 50+

Insufflated duration: onset 5-15m · peak 1-3h · after-effects 1-3h
Vapourized duration: onset 1-30m · peak 1-1.5h · after-effects 1-3h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 50 mg (Insufflated).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.