Propylhexedrine Stats - Substance Search

Pharmacology

DrugBank

State Solid

Description

Propylhexedrine is an alpha-adrenergic agonist often used in nasal decongestant inhalers. It is used to give temporary relief for nasal congestion from colds, allergic rhinitis, or allergies.

Mechanism of Action

Propylhexidrine causes the norepinephrine, dopamine, and serotonin (5HT) transporters to reverse their direction of flow. This inversion leads to a release of these transmitters from the vesicles to the cytoplasm and from the cytoplasm to the synapse. It also antagonizes the action of VMAT2, causing the release of more neurotransmitters.

Pharmacodynamics

Like other monoamine releasing stimulants propylhexedrine is active as a norepinephrine and dopamine releaser in the central nervous system. The acute effects of the drug closely resemble the physiological and psychological effects of an epinephrine-provoked fight-or-flight response, including increased heart rate and blood pressure, vasoconstriction (constriction of the arterial walls), bronchodilation, and hyperglycemia (increased blood sugar).

Indication

It is used to provide temporary symptomatic relief of nasal congestion due to colds, allergies and allergic rhinitis.

Receptor Profile

Receptor Actions

Agonists

TAAR1 agonist

Inhibitors

VMAT2 inhibitor

Other

Serotonin-norepinephrine-dopamine releasing agent (SNDRA)

Receptor Binding

Synaptic vesicular amine transporter antagonist

Alpha-2C adrenergic receptor modulator

Trace amine-associated receptor 1 agonist

Toxicity

PsychonautWiki DrugBank

The toxicity of recreational propylhexedrine use has not been studied as extensively as that of amphetamine or methamphetamine but it is reasonable to assume that most if not all of the same risks apply. It is strongly recommended that one use harm reduction practices when using this substance.

Toxicity (DrugBank)

The signs and symptoms that are produced after the acute overdosage of Propylhexidrine include Psychosis, Burning sensation.

Effect Profile

Curated + 62 Reports

Stimulant 4.9

Moderate focus with strong anxiety/jitters, mild stimulation and euphoria

Stimulation / Energy×3

5

Euphoria / Mood Lift×2

5

Focus / Productivity×2

7

Anxiety / Jitters×1

10

Based on reports from:

Erowid Experience Reports PsychonautWiki Propylhexedrine

Tolerance & Pharmacokinetics

drugs.wiki

Tolerance Decay

Full tolerance 1d Half tolerance 5d Baseline ~14d

Cross-Tolerances

Amphetamine

Methamphetamine

Experience Report Analysis

Erowid BlueLight

31 Reports

15 Single-substance

2005–2025 Date Range

19 With Age Data

8 Effects Detected

Demographics

Gender Distribution

Age Distribution

Reports Over Time

Effect Analysis

Erowid + Bluelight

Effects aggregated from 62 experience reports (15 single-substance Erowid + 47 Bluelight)

62 Reports

117 Effects Detected

46 Positive

52 Adverse

19 Neutral

Effect Sentiment Distribution

Confidence Distribution

Each bar is the share of reports mentioning the effect; its whisker, and the band on the rows below, is the 95% interval: where the share could plausibly be with other reports of the same kind.

Positive Effects 46

Stimulation 80.7% 87%

Euphoria 66.2% 87%

Focus Enhancement 43.6% 84%

Tingling 42.6% 86%

Sociability Enhancement 38.3% 85%

Contentment 23.4% 80%

Music Enhancement 21.0% 83%

Thought Acceleration 19.1% 81%

Body High 14.5% 79%

Libido Enhancement 8.5% 85%

Motor Enhancement 6.4% 80%

Enhanced Colors 6.4% 78%

Joy 6.4% 85%

Confidence 6.4% 88%

Empathy 4.3% 88%

Meta-Awareness Of Irrationality 4.3% 90%

Empathogenic Connection 4.3% 80%

Creativity Enhancement 4.3% 82%

Mood Lift 4.3% 88%

Introspection 4.3% 85%

Adverse Effects 52

Body Load 25.5% 78%

Headache 25.5% 83%

Anxiety 21.0% 73%

Nausea 17.7% 85%

Restlessness 17.0% 77%

Insomnia 17.0% 79%

Irritability 12.8% 80%

Dysphoria 12.8% 83%

Thought Disorganization 10.6% 77%

Taste Distortion 8.5% 79%

Jaw Clenching 6.4% 82%

Paranoia 6.4% 82%

Stomach Cramps 6.4% 73%

Vomiting 6.4% 92%

Tachycardia 6.4% 87%

Dry Mouth 6.4% 82%

Panic 4.3% 90%

Delusion 4.3% 82%

Tremor 4.3% 85%

Numbness 4.3% 80%

⚠ Chest Pain 2.1% 95%

Show 31 more adverse effects

Motor Suppression 4.3% 72%

Body Temperature Change 4.3% 80%

Distractibility 4.3% 80%

Heaviness 4.3% 75%

Lightness 4.3% 72%

Dizziness 4.3% 82%

Pain Enhancement 4.3% 78%

Anhedonia 2.1% 90%

Jitteriness 2.1% 75%

Anger 2.1% 90%

Auditory Hallucination 2.1% 85%

Emotional Lability 2.1% 85%

Hot Flashes 2.1% 90%

Chills 2.1% 75%

Muscle Twitching 2.1% 80%

Peripheral Imagery 2.1% 75%

Dissociation 2.1% 70%

Thought Deceleration 2.1% 75%

Diarrhea 2.1% 80%

Disrupted Sleep Architecture 2.1% 80%

Ego Inflation 2.1% 90%

Throat Irritation 2.1% 80%

Genital Sensitivity Change 2.1% 90%

Dry Eyes 2.1% 85%

Itching 2.1% 85%

Pupil Constriction 2.1% 85%

Muscle Cramp 2.1% 85%

Sadness 2.1% 80%

Hypersomnia 2.1% 85%

Isolation Preference 2.1% 80%

Fear 2.1% 80%

Show 19 neutral or unclassified mentions

Appetite Suppression 31.9%

Sedation 16.2%

Sweating 14.9%

Visual Trails 6.4%

Visual Hallucination 6.4%

Entity Imagery 4.3%

Pupil Dilation 4.3%

Heart Rate Increase 4.3%

Flushing 4.3%

Involuntary Movements 2.1%

Field Narrowing 2.1%

Frequent Urination 2.1%

Lucid Dreaming 2.1%

Penile Effects 2.1%

Skin Crawling 2.1%

Time Dilation 2.1%

Pressure 2.1%

Drowsiness 2.1%

Depersonalization 2.1%

Also reported in combinations. In the 16 Propylhexedrine reports where another drug was taken too, 0 mention hospital, emergency services or an overdose, 0 a seizure and 1 psychosis (too few reports for percentages). In the 15 single-substance reports: 2, 0 and 0. These are not in the figures above: they cannot be put down to Propylhexedrine alone, and a mention is not always something that happened to the writer.

Dosage Distribution

Dose distribution from experience reports, one dose per report (the first listed). Doses above Q3 + 3×IQR, far above what people typically take, are left out of the median and range and listed under each route: most are real heavy doses or overdoses, not mistakes.

Median: 250.0 mg IQR: 137.5–250.0 mg n=11

1 report gave a dose above the typical range (1,000 mg), so it is not in the figures above. Listing a dose here does not mean it is safe.

Show the report

1,000 mg · another drug taken too

Real-World Dose Distribution

Erowid

From 46 of 51 recorded dose entries: those that state a weight (mg, g or µg), in routes with at least five of them. Values above Q3 + 3×IQR, far above what people typically take, are left out; they can include real heavy doses and overdoses, not only mistakes.

Oral (n=45)

Median: 250.0mg 25th: 250.0mg 75th: 250.0mg 90th: 500.0mg

Common Combinations

Most co-occurring substances, as a share of all 31 reports filed under Propylhexedrine; whiskers are 95% intervals

Form / Preparation

Most common forms and preparations, as a share of the 8 reports that give one

Too few reports for bars: these forms come from 8 reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?

Liquid 3 of 8
Pill / Tablet 2 of 8
Capsule 2 of 8

Body-Weight Dosing

Dose per kg of body weight, one dose per report (the first listed), from reports giving a weight of 30–250 kg. Doses above Q3 + 3×IQR, far above what people typically take, are left out of the median and range and listed under each route.

Median: 2.9 mg/kg IQR: 1.966–3.449 mg/kg n=11

1 report gave a dose above the typical range (11.025 mg/kg), so it is not in the figures above. Listing a dose here does not mean it is safe.