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    Progesterone Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 1 source
    • 2 ROAs with full dose ladders
    • toxicity data (PsychonautWiki, PubChem)

    Depressant

    Summary PsychonautWiki

    Pregn-4-ene-3,20-dione, also known as Progesterone or P4 is a steroid sex hormone of the progestogen class. It occurs naturally and is the bodies major progestogen.

    Dose Information dose.wiki PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 100-200mg 200-400mg 400-600mg 600mg+
    Rectal 100-200mg 200-400mg 400-600mg 600mg+
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — dose.wiki, PsychonautWiki

    Rectal

    Dose ladder — dose.wiki, PsychonautWiki

    Tolerance

    Build-up develops over 1–4 weeks of regular use
    Reset days to weeks depending on duration of use

    Tolerance Decay

    Full tolerance 3d Half tolerance 8d Baseline ~14d

    Effects

    Negative
    Neutral
    Positive
    Negative
    • Elevated aggression/drive
    Neutral
    • Mood changes
    Positive
    Negative
    Neutral

    Pill Identifiers

    7 known pill identifiers on record — view imprints, colors, shapes, and images
    →
    Progesterone's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📖 PsychonautWiki
    Import into PsychonautWiki Journal

    The PsychonautWiki Journal app includes Progesterone, but its built-in data can be thinner than ours. Importing this file adds a separate "Progesterone (Substance Search)" custom substance with our dose ranges, durations and tolerance, so you can log against whichever you prefer.

    ⬇ Download import file Import this file as custom substances and you get "Progesterone (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer.

    Ranges are harm-reduction guidance, not a prescription.