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    ๐Ÿงช This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    PPAP Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 29 combo interactions documented
    • classified Research-chemical

    Aliases: Dppea, Mk-306, N,ฮฑ-dipropylphenethylamine

    Stimulant Nootropic Research-chemical

    Summary dose.wiki

    PPAP's sublingual route can irritate mucosa and its effect curve plateaus quickly. Tolerance tends to fade after roughly three days, but reagent testing and sub-10 mg allergy checks remain best practice. Unlike traditional stimulants, PPAP enhances neurotransmitter release only in response to neural activity rather than causing uncontrolled monoamine flooding.

    Dose Information PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 10-30mg 30-50mg 50-100mg 100mg+
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — PsychonautWiki

    Onset, Duration & After-effects dose.wiki PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 30-60 min 10-30 min 2-3 hrs 2-5 hrs - 4-7 hrs
    Sublingual / Buccal - - 1-3 hrs 1-2 hrs 1-4 hrs 2-5 hrs
    Insufflated 5-10 min - 1-3 hrs 1-2 hrs 1-4 hrs 2.08-5.17 hrs
    Intramuscular 2-5 min - 1-3 hrs 1-2 hrs 1-4 hrs 2.03-5.08 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 5.6
    Strong 6/10

    Moderate euphoria, focus, and anxiety/jitters with mild stimulation

    Stimulation / Energy ×3
    5
    stimulation stamina enhancement
    Euphoria / Mood Lift ×2
    7
    physical euphoria cognitive euphoria increased motivation
    Focus / Productivity ×2
    6
    focus enhancement analysis enhancement
    ⚠ Anxiety / Jitters ×1
    6
    anxiety increased heart rate
    Based on reports from:
    PsychonautWiki PPAP
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3โ€“7 days for acute; 1โ€“3 weeks for full reset

    Tolerance Decay

    Full tolerance 3d Half tolerance 4d Baseline ~21d

    Patterns are based on user reports: repeated daily dosing for multiple days appears to reduce desired effects and increase anxiety/insomnia; spacing use by several days to a week helps preserve efficacy. Cross-tolerance with other CAE/MAE agents (e.g., BPAP) is plausible but unquantified. Data quality is limited.

    Cross-Tolerances

    selegiline
    BPAP

    Effects dose.wiki

    Positive
    Negative
    Neutral
    Positive
    Negative
    Positive
    Negative
    Neutral

    Combinations

    Cross-Check PPAP with another substance

    PPAP's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    ๐Ÿ“˜ Experience Reports ๐Ÿ“– dose.wiki ๐Ÿ“– PsychonautWiki
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track PPAP there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "PPAP (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    PPAP
    Unit
    mg
    Description 
    PPAP
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 10 ยท light 10-30 ยท common 30-50 ยท strong 50-100 ยท heavy 100+
Sublingual / Buccal dose (mg): threshold 3
Insufflated dose (mg): threshold 2
Intramuscular dose (mg): threshold 2

Oral duration: onset 0.5-1h ยท come-up 10-30m ยท peak 2-3h ยท offset 2-5h ยท total 4-7h
Sublingual / Buccal duration: peak 1-3h ยท offset 1-2h ยท total 2-5h ยท after-effects 1-4h
Insufflated duration: onset 5-10m ยท peak 1-3h ยท offset 1-2h ยท total 2.08-5.17h ยท after-effects 1-4h
Intramuscular duration: onset 2-5m ยท peak 1-3h ยท offset 1-2h ยท total 2.03-5.08h ยท after-effects 1-4h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 40 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.