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    Phenmetrazine Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 1 source
    • partial dose data
    • duration data present
    • PubChem toxicity data

    Aliases: Preludin

    Summary TripSit

    Stimulant drug that was previously used as an appetite suppresant, has been withdrawn from the market, due to concerns of abuse and addiction. Usually produces less nervousness, euphoria, and insomnia than drugs of the amphetamine family. Also as a study concluded, it is slightly more effective than dextroamphetamine as a weight loss agent.

    Dose Information dose.wiki TripSit

    ROA Common
    Oral 25-50mg
    Common
    Sources

    Oral

    Dose ladder — dose.wiki, TripSit

    Onset, Duration & After-effects TripSit

    ROA Onset Peak After Effects Total
    Oral 15-30 min 4-8 hrs 1-12 hrs 4-8 hrs

    Effect Profile

    Scores (0–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 4.5
    Moderate 4/10

    Strong euphoria with strong anxiety/jitters, moderate stimulation

    Stimulation / Energy ×3
    6
    stimulation wakefulness alertness enhancement
    Euphoria / Mood Lift ×2
    9
    physical euphoria cognitive euphoria euphoria
    Focus / Productivity ×2
    0
    ⚠ Anxiety / Jitters ×1
    10
    anxiety increased heart rate teeth grinding vasoconstriction

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute tolerance; longer for full reset

    Tolerance Decay

    Full tolerance 1d Half tolerance 10d Baseline ~18d

    Effects

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    →

    Helpful Links

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track Phenmetrazine there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    Name
    Phenmetrazine
    Unit
    mg
    Description
    Phenmetrazine
    Source: SubstanceSearch (substancesearch.com)
    
    Oral dose (mg): common 25-50
    
    Oral duration: onset 15-30m · peak 4-8h · total 4-8h · after-effects 1-12h
    
    Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 37.5 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.