Beta test rollout. This site is in community QA — please send feature requests, bug reports and data corrections on the Feedback page or on GitHub.

Home
    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Pemoline Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 29 combo interactions documented
    • PubChem toxicity data
    • classified Research-chemical

    Stimulant Research-chemical

    Summary dose.wiki TripSit

    Pemoline was used primarily for ADHD and narcolepsy but has been withdrawn in many countries due to rare but severe hepatotoxicity. It is not considered to have strong euphoric or recreational effects compared to other stimulants. Monitoring of liver function is essential if used.

    Dose Information dose.wiki TripSit

    ROA Light Common Strong Heavy
    Oral 10-20mg 20-40mg 40-80mg 80mg+
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — dose.wiki, TripSit

    Onset, Duration & After-effects dose.wiki TripSit

    ROA Onset Peak Offset After Effects Total
    Oral 30-60 min 2-4 hrs 4-8 hrs 1-6 hrs 4-13 hrs

    Effect Profile

    Scores (0–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 6.2
    Strong 6/10

    Strong stimulation with strong anxiety/jitters, mild euphoria and focus

    Stimulation / Energy ×3
    10
    stimulation increased energy wakefulness alertness enhancement mild stimulation
    Euphoria / Mood Lift ×2
    5
    euphoria motivation enhancement
    Focus / Productivity ×2
    5
    focus enhancement motivation enhancement
    ⚠ Anxiety / Jitters ×1
    10
    anxiety increased heart rate teeth grinding vasoconstriction
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute; 1–3 weeks for full reset

    Tolerance Decay

    Full tolerance 14d Half tolerance 7d Baseline ~28d

    Empirical tolerance data specific to pemoline are sparse; patterns likely resemble other prescription stimulants with modest psychological tolerance and limited pharmacodynamic tolerance due to unique mechanism and low euphoria. Users report needing higher doses after weeks of daily use, with partial reversal after several weeks off. Treat as anecdotal.

    Cross-Tolerances

    Other stimulants (general)

    Effects dose.wiki

    Positive
    Negative
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral

    Combinations TripSit

    Cross-Check Pemoline with another substance

    Pill Identifiers

    5 known pill identifiers on record — view imprints, colors, shapes, and images
    →
    Pemoline's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📖 dose.wiki 📖 TripSit
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track Pemoline there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "Pemoline (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    Pemoline
    Unit
    mg
    Description 
    Pemoline
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): light 10-20 · common 20-40 · strong 40-80 · heavy 80+

Oral duration: onset 0.5-1h · peak 2-4h · offset 4-8h · total 4-13h · after-effects 1-6h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 30 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.