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    Paracetamol Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • partial dose data
    • duration data present
    • PubChem toxicity data

    Aliases: Apap, Tylenol, Acetaminophen, Pain reliever extra strength

    Summary Erowid TripSit

    Acetaminophen is a non-salicylate analgesic and antipyretic (pain killer and fever reducer). It is a common over-the-counter pain medication found in hundreds of products around the world. At higher doses it is known to cause liver-damage and has a low therapeutic index (ratio of effective dose to toxic dose), making it dangerous when included in recreationally used pharmaceuticals.

    Dose Information dose.wiki TripSit

    ROA Common
    Oral 200-500mg
    Common
    Sources

    Oral

    Dose ladder — dose.wiki, TripSit

    Onset, Duration & After-effects TripSit

    ROA Onset Peak After Effects Total
    Oral 60 min 4-6 hrs 1-2 hrs 4-6 hrs

    Tolerance

    Build-up varies by mechanism; therapeutic tolerance may develop over weeks of regular use
    Reset typically days to weeks after discontinuation

    Tolerance Decay

    Full tolerance 3d Half tolerance 8d Baseline ~14d

    Effects

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral

    Pill Identifiers

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    Helpful Links

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track Paracetamol there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    Name
    Paracetamol
    Unit
    mg
    Description
    Paracetamol
    Source: SubstanceSearch (substancesearch.com)
    
    Oral dose (mg): common 200-500
    
    Oral duration: onset 1h · peak 4-6h · total 4-6h · after-effects 1-2h
    
    Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 350 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.