Beta test rollout. This site is in community QA — please send feature requests, bug reports and data corrections on the Feedback page or on GitHub.

Home
    Disclaimer

    Nitromethaqualone Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 1 source
    • 2 ROAs with full dose ladders
    • toxicity data (PsychonautWiki)

    Depressant

    Summary PsychonautWiki

    Nitromethaqualone is a central nervous system (CNS) depressant of the quinazolinone class that acts as a sedative and hypnotic. Nitromethaqualone is a derivative of methaqualone, distinguished by the presence of a nitro group, which affects its pharmacological profile. While methaqualone gained popularity in the 1960s and 70s, nitromethaqualone has been studied less extensively but exhibits similar depressant effects.

    Dose Information PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 10-25mg 25-50mg 50-60mg 60mg+
    Insufflated 5-10mg 10-30mg 30-60mg 60mg+
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — PsychonautWiki

    Insufflated

    Dose ladder — PsychonautWiki
    ⚠ above 300 mg oral Dangerous for first-time users
    ☠ around 8 g/day oral Can be fatal (tolerance-dependent)

    “Doses of over 300mg can be dangerous for first-time users.” — toxicity literature
    “Depending on the user's individual tolerance, doses of about 8,000mg per day can be fatal, while some users on higher doses (up to 20,000mg) may survive.” — toxicity literature

    Tolerance

    Build-up develops over 1–4 weeks of regular use
    Reset Falls after you stop, at a rate that varies from person to person. If you've been using regularly, cut down gradually with medical help rather than stopping suddenly.

    No tolerance chart. Our decay curves for these drugs were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.

    How fast tolerance to these drugs fades after a break has not been measured well enough to draw, so don't count on a dose you used to take still being safe: after time off, start with a much smaller amount and don't use alone. Mixing sedatives with each other, with alcohol or with opioids sharply raises the risk of a fatal overdose. If you've been using regularly, don't stop suddenly: withdrawal from benzodiazepines, alcohol or GHB/GBL can cause seizures or delirium, so get medical help to cut down gradually.

    Sources: FRANK: benzodiazepines · Alcohol and Drug Foundation: GHB · FDA 2020: benzodiazepine boxed warning · FDA 2019: gabapentinoids and breathing · NHS: alcohol use disorder

    Effects

    Positive
    Negative
    Neutral
    Positive
    Negative
    Positive
    Negative
    Neutral
    Nitromethaqualone's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📖 PsychonautWiki
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track Nitromethaqualone there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "Nitromethaqualone (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    Nitromethaqualone
    Unit
    mg
    Description 
    Nitromethaqualone
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 10 · light 10-25 · common 25-50 · strong 50-60 · heavy 60+
Insufflated dose (mg): threshold 5 · light 5-10 · common 10-30 · strong 30-60 · heavy 60+

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 37.5 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.