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    N-Acetylcysteine Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • PubChem toxicity data

    Aliases: Nac, Acetylcysteine

    Nootropic Supplement

    Summary PsychonautWiki

    N-Acetylcysteine (NAC), also known as Acetylcysteine, is a medication that is used to treat paracetamol (acetaminophen) overdose, and to loosen thick mucus in individuals with chronic bronchopulmonary disorders like pneumonia, bronchitis and cystic fibrosis. It has been used to treat lactobezoar in infants. It can be taken intravenously, by mouth, or inhaled as a mist.

    Dose Information dose.wiki PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 400-600mg 600-1000mg 1000-1500mg 1500mg+
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — dose.wiki, PsychonautWiki

    Onset, Duration & After-effects dose.wiki PsychonautWiki

    ROA Onset Peak Offset Total
    Oral 20-60 min 1-3 hrs 2-4 hrs 3-6 hrs

    Tolerance

    Build-up varies by mechanism; therapeutic tolerance may develop over weeks of regular use
    Reset typically days to weeks after discontinuation

    Tolerance Decay

    Full tolerance 3d Half tolerance 8d Baseline ~14d

    Effects dose.wiki

    Positive
    Negative
    Neutral
    Positive
    Negative
    Positive
    Negative
    Neutral
    N-Acetylcysteine's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📖 dose.wiki 📖 PsychonautWiki
    Import into PsychonautWiki Journal

    The PsychonautWiki Journal app includes N-Acetylcysteine, but its built-in data can be thinner than ours. Importing this file adds a separate "N-Acetylcysteine (Substance Search)" custom substance with our dose ranges, durations and tolerance, so you can log against whichever you prefer.

    ⬇ Download import file Import this file as custom substances and you get "N-Acetylcysteine (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer.

    Ranges are harm-reduction guidance, not a prescription.