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MT-45 Stats & Data

Depressant Research-chemical Opioid

Ic-6 mt45

PubChem CID 431865

NPS DataHub

MW348.53

FormulaC24H32N2

CAS52694-55-0

IUPAC1-Cyclohexyl-4-(1,2-diphenylethyl)piperazine

SMILESC1CCC(CC1)N1CCN(CC1)C(Cc1ccccc1)c1ccccc1

InChIKeyIGBRRSIHEGCUEN-UHFFFAOYSA-N

Phenethylamines

Chemical Class Piperazine opioid

Psychoactive Class Depressant

Measured Affinities

Guide to PHARMACOLOGY

Measured binding and functional data for MT-45, curated by the IUPHAR/BPS Guide to PHARMACOLOGY. Each row cites the paper it came from. Lower concentrations mean tighter binding — a value in the sub-nanomolar range indicates a very potent interaction.

Target	Action	Measure	Value	Concentration	Species	Source
μ receptor OPRM1	Agonist	pEC50	4.64	22,909 nM	Human	PMID 32246840

Reading this. pKi, pEC50 and pIC50 are negative log molar values, so a higher number means a tighter interaction; the concentration column converts them for you. Values from non-human species are laboratory measurements and do not translate directly to human effect. Receptor affinity is not a dose — it describes what a molecule binds, not how much of it is safe to take.

Receptor data from the IUPHAR/BPS Guide to PHARMACOLOGY (v2026.2), licensed CC BY-SA 4.0. Matched to this substance by InChIKey.

Effect Profile

Curated + 3 Reports

Opioid 6.3

Strong euphoria with moderate itching/nausea, mild pain relief, low sedation

Euphoria / Warmth×3

Analgesia×2

Sedation / Relaxation×1

Itching / Nausea×1

Based on reports from:

Erowid Experience Reports

Tolerance & Pharmacokinetics

drugs.wiki

No tolerance chart. Our decay curves for opioids were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.

Opioid tolerance drops fast when you stop, and even a few days off can be enough, so a dose that used to be normal can now stop your breathing. Overdose deaths rise sharply after prison, detox or leaving treatment, and tolerance also falls during a hospital stay. After any break, start with a much smaller amount, try a test dose first, don't use alone, and keep naloxone within reach. Alcohol, benzodiazepines, gabapentinoids and other sedatives make an opioid overdose much more likely.

Sources: FRANK: heroin · National Harm Reduction Coalition · WHO: opioid overdose · Merrall et al. 2010 · Binswanger et al. 2007 · Strang et al. 2003 · FDA 2019: gabapentinoids and breathing

Experience Report Analysis

Erowid

4 Reports

3 Single-substance

2012–2015 Date Range

4 With Age Data

Demographics

Gender Distribution

Too few reports for a chart: gender is known from 4 reports, and a split is drawn only from 20 reports or more. Counts are shown instead. Why 20?