Before we jump into the details of MT-45, a little about myself. I have been around the block a bit myself with opioids before. In my flirtations with Lady Poppy, I have tasted several natural and synthetic opioids: heroin, kratom, opium, poppy tea (oddly enough, my favorite opiate of the bunch -- nothing can quite bea...
MT-45
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 29 combo interactions documented
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 29 combo interactions documented
- classified Research-chemical
Aliases: Ic-6, mt45
Summary
A synthetic opioid drug that was rumoured to be roughly 80% the potency of Morphine orally. Was created by Dainippon Pharmaceutical in the 1970's. It has been used as a lead compound for the design of related substances.
Dose Information
| ROA | Light | Common | Strong |
|---|---|---|---|
| Oral | 30-45mg | 45-60mg | 60mg+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Total |
|---|---|---|---|
| Oral | 30-45 min | 4-6 hrs | 4-6 hrs |
Effect Profile
3 reportsScores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Opioid
6.3
Strong
6/10
Strong euphoria with moderate itching/nausea, mild pain relief, low sedation
Euphoria / Warmth
×3
10
physical euphoria
euphoria
cognitive euphoria
mood lift
Analgesia
×2
4
analgesia
Sedation / Relaxation
×1
3
sedation
Itching / Nausea
×1
7
nausea
constipation
dry mouth
Based on reports from:
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
Falls quickly once you stop, at a rate you can't judge. After any break, treat your tolerance as gone.
No tolerance chart. Our decay curves for opioids were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.
Opioid tolerance drops fast when you stop, and even a few days off can be enough, so a dose that used to be normal can now stop your breathing. Overdose deaths rise sharply after prison, detox or leaving treatment, and tolerance also falls during a hospital stay. After any break, start with a much smaller amount, try a test dose first, don't use alone, and keep naloxone within reach. Alcohol, benzodiazepines, gabapentinoids and other sedatives make an opioid overdose much more likely.
Sources: FRANK: heroin Β· National Harm Reduction Coalition Β· WHO: opioid overdose Β· Merrall et al. 2010 Β· Binswanger et al. 2007 Β· Strang et al. 2003 Β· FDA 2019: gabapentinoids and breathing
Effects
Effect glossary — · full glossary
Positive
Negative
Positive
Negative
Positive
Negative
Combinations
Cross-Check MT-45 with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 3 reports 1 positive 1 neutral 1 cautionary visit
I acquired a sample of this substance, not having much experience with opiates. This is supposedly an opiate analog that is 80% as potent as Morphine. I'd have to say from my initial study, that the statement is correct.
I acquired 1 gram. I had no real ideas about it besides what receptor it bound to (mu negative). A classic opioid it seemed. I have had experiences with vicodin/ oxyΒs before (as in chew up a bit too many for my own good). The first time I tried it I did it as a suppository.
MT-45's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track MT-45 there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Name
MT-45
Unit
mg
Description
MT-45 Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 30 Β· light 30-45 Β· common 45-60 Β· strong 60+ Oral duration: onset 30-45m Β· peak 4-6h Β· total 4-6h Β· after-effects 2-3h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 52.5 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
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