When reading unpleasant/negative trip reports, it never fails to amaze me how: A) The Bluelight forums and/or search engine + erowid, could almost certainly have provided enough information to prevent/limit the degree to which a user mistakenly set off on a journey into probable unpleasantness.
Mitragynine
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 29 combo interactions documented
- dose data not in PW/TripSit (unverifiable)
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 29 combo interactions documented
- dose data not in PW/TripSit (unverifiable)
Aliases: 9-methoxycorynantheidine
Summary
Mitragynine is the primary active alkaloid in kratom (Mitragyna speciosa), accounting for 12-66% of total alkaloid content depending on strain origin. Unlike traditional opioids, mitragynine displays functional selectivity and does not activate the β-arrestin-2 pathway, which may contribute to reduced respiratory depression risk compared to morphine. However, pure extracts carry significantly greater overdose risk than plant material due to the natural nausea ceiling in leaf powder.
Dose Information
Dose basis. Dose figures for mitragynine depend entirely on what is being weighed. Dried leaf commonly runs 12-21 mg/g mitragynine and some resins 35-63 mg/g, so identical gram weights of different material can differ several-fold in active content, and isolated mitragynine is not interchangeable with leaf by weight at all.
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 1-2g | 2-5g | 5-8g | 8g+ |
Light
Common
Strong
Heavy
Sources
Oral
Dose ladder — Drugs.WikiOnset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 15-45 min | 1-2 hrs | 2-4 hrs | 4-6 hrs |
Effect Profile
1 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Stimulant
5.9
Strong
6/10
Moderate euphoria and focus with low stimulation
Stimulation / Energy
×3
3
stimulation
Euphoria / Mood Lift
×2
7
physical euphoria
cognitive euphoria
motivation enhancement
Focus / Productivity
×2
7
focus enhancement
motivation enhancement
thought acceleration
Anxiety / Jitters
×1
0
Opioid
5.1
Moderate+
5/10
Moderate euphoria, sedation, and itching/nausea with mild pain relief
Euphoria / Warmth
×3
6
physical euphoria
cognitive euphoria
Analgesia
×2
4
pain relief
Sedation / Relaxation
×1
6
sedation
muscle relaxation
dream potentiation
Itching / Nausea
×1
6
nausea
constipation
Based on reports from:
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Tolerance Decay
Full tolerance
7d
Half tolerance
7d
Baseline
~35d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Daily use rapidly builds tolerance and produces a short, opioid‑like withdrawal; most users report substantial recovery within 3–7 days after cessation. Cross‑tolerance with other MOR agonists is partial. Data quality is primarily observational/user‑reported; controlled human data are limited.
Cross-Tolerances
Effects
Effect glossary — · full glossary
Positive
Negative
Positive
Negative
Positive
Negative
Combinations
Cross-Check Mitragynine with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Bluelight 1 thread 1 neutral visit
Mitragynine's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Mitragynine there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
⬇ Download import file
Import this file as custom substances
and you get "Mitragynine (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer. The manual values below work for older
versions.
Name
Mitragynine
Unit
g
Description
Mitragynine Source: SubstanceSearch (substancesearch.com) Oral dose (g): threshold 0.5-1 · light 1-2 · common 2-5 · strong 5-8 · heavy 8+ Oral duration: onset 15-45m · peak 1-2h · offset 2-4h · total 4-6h · after-effects 24h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 3.5 g (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Report an issue or suggest an edit
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