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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Mexedrone Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 4 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 29 combo interactions documented
    • toxicity data (PsychonautWiki)
    • classified Tentative
    • classified Research-chemical

    Aliases: 4-mmeoc, 4-mmc-meo

    Stimulant Empathogen Research-chemical

    Summary dose.wiki TripSit PsychonautWiki

    Mexedrone is a research chemical with very little history of human use prior to 2015. It was marketed as a legal alternative to mephedrone but is reported to be approximately 10-20 times weaker in potency, requiring higher doses to achieve comparable effects. The substance has been associated with significant sedation rather than stimulation, distinguishing it from mephedrone.

    Dose Information source varies by route

    ROA Light Common Strong Heavy
    Oral 100-150mg 150-250mg 250-350mg 350mg+
    Insufflated 50-80mg 80-120mg 120-200mg 200mg+
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — PsychonautWiki

    Insufflated

    Dose ladder — dose.wiki, TripSit

    Onset, Duration & After-effects dose.wiki TripSit PsychonautWiki

    ROA Onset Peak Offset After Effects Total
    Oral 30-60 min 2-3 hrs 1-2 hrs 2-12 hrs 4-6 hrs
    Insufflated 5-20 min 1.5-2.5 hrs 1-2 hrs 2-12 hrs 1-3 hrs

    Effect Profile

    Scores (0–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Empathogen 4.7
    Moderate+ 5/10

    Strong euphoria and sensory enhancement with moderate stimulation

    Empathy / Social Openness ×3
    0
    Euphoria / Mood Elevation ×2
    9
    physical euphoria euphoria cognitive euphoria
    Stimulation ×1
    7
    stimulation wakefulness teeth grinding increased heart rate
    Sensory Enhancement ×1
    8
    tactile enhancement spontaneous tactile sensations increased libido
    Stimulant 4.9
    Moderate+ 5/10

    Strong euphoria with strong anxiety/jitters, mild stimulation, low focus

    Stimulation / Energy ×3
    5
    stimulation wakefulness
    Euphoria / Mood Lift ×2
    9
    physical euphoria euphoria cognitive euphoria
    Focus / Productivity ×2
    2
    thought acceleration
    ⚠ Anxiety / Jitters ×1
    8
    anxiety teeth grinding increased heart rate
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Mexedrone The Drug Users Bible Mexedrone
    View methodology →

    Tolerance

    Build-up develops rapidly, often within a single session; compulsive redosing common
    Reset a few days for acute tolerance

    Tolerance Decay

    Full tolerance 1h Half tolerance 7d Baseline ~14d

    Effects dose.wiki TripSit

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral

    Combinations TripSit

    Cross-Check Mexedrone with another substance

    Mexedrone's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki 📖 TripSit 📖 The Drug Users Bible
    Add missing routes to PsychonautWiki Journal

    The PsychonautWiki Journal app already has Mexedrone, but its built-in entry only covers Oral. Here are the other routes we have data for. You can't edit a built-in substance, but you can add a Custom Unit for any of these routes to log it.

    ⬇ Download import file Import this file as custom substances and you get "Mexedrone (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Custom Unit doses
    • Insufflatedcommon ~ 100 mg
    Dose & duration (reference) 
    Mexedrone: routes the PsychonautWiki Journal app is missing
Source: SubstanceSearch (substancesearch.com)

Insufflated dose (mg): light 50-80 · common 80-120 · strong 120-200 · heavy 200+

Insufflated duration: onset 5-20m · peak 1.5-2.5h · offset 1-2h · total 1-3h · after-effects 2-12h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Custom Units carry a single dose per route, so the full ranges live in the reference above. A route's suggested dose is the midpoint of its common range. Ranges are harm-reduction guidance, not a prescription.