Metizolam
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 4 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 27 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Tentative
- classified Research-chemical
- 4 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 27 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Tentative
- classified Research-chemical
Aliases: Metiz, Desmethyletizolam
Summary
Metizolam is a research chemical with very little history of human use and minimal scientific study. It was patented in 1995 but never marketed as a medication. Due to its extreme potency, volumetric liquid dosing is strongly recommended to ensure accurate administration.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 1-2mg | 2-4mg | 4-6mg | 6mg+ |
Sources
Oral
Dose ladder — dose.wiki, PsychonautWiki, TripSitOnset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 30-90 min | 30 min | 3-6 hrs | 5-8 hrs |
Effect Profile
Scores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong anxiolysis and euphoria with moderate cognitive impairment, mild sedation
Tolerance
No tolerance chart. Our decay curves for these drugs were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.
How fast tolerance to these drugs fades after a break has not been measured well enough to draw, so don't count on a dose you used to take still being safe: after time off, start with a much smaller amount and don't use alone. Mixing sedatives with each other, with alcohol or with opioids sharply raises the risk of a fatal overdose. If you've been using regularly, don't stop suddenly: withdrawal from benzodiazepines, alcohol or GHB/GBL can cause seizures or delirium, so get medical help to cut down gradually.
Sources: FRANK: benzodiazepines · Alcohol and Drug Foundation: GHB · FDA 2020: benzodiazepine boxed warning · FDA 2019: gabapentinoids and breathing · NHS: alcohol use disorder
Effects
Effect glossary — · full glossary
Combinations
Cross-Check Metizolam with another substanceHelpful Links
Import into PsychonautWiki Journal
The PsychonautWiki Journal app includes Metizolam, but its built-in data can be thinner than ours. Importing this file adds a separate "Metizolam (Substance Search)" custom substance with our dose ranges and durations, so you can log against whichever you prefer. It leaves tolerance out on purpose, for the reason given under Tolerance above.
Ranges are harm-reduction guidance, not a prescription.
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for Metizolam? Let us know. Reports are reviewed by moderators — this is not posted publicly.