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MEM
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 30 combo interactions documented
- classified Tentative
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 30 combo interactions documented
- classified Tentative
- classified Research-chemical
Summary
MEM is a rare psychedelic amphetamine first synthesized by Alexander Shulgin and described in PiHKAL as entry #122. It is structurally related to mescaline and other DOx compounds. Human data is extremely limited, making effects unpredictable.
Perspectives
“I experienced some physical discomfort, but doesn’t that tell us about the work to be done, rather than the property of the material? The breakthrough I had was the following day (and this seems to be the way MEM operates, i.e., first the energy and expansion, next day insight) was of the highest value and importance for me. I was given a methodology for dealing with my shadow parts. No small gift. And I did it all alone and the results were immediate. I am so grateful.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 15-25mg | 25-35mg | 35-45mg+ | 45mg+ |
Light
Common
Strong
Heavy
Sources
Oral
Dose ladder — TripSitOnset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 30-90 min | 1-2 hrs | 3-6 hrs | 3-6 hrs | 8-16 hrs |
Effect Profile
Scores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
5.0
Moderate+
5/10
Strong visuals with moderate body load, mild headspace
Visual Intensity
×3
8
color enhancement
drifting
visual enhancement
pattern recognition enhancement
brightened colour
Headspace Depth
×3
4
conceptual thinking
time distortion
confusion
Auditory Effects
×1
0
Body Load / Somatic Effects
×1
6
vasoconstriction
muscle tension
increased heart rate
Stimulant
2.4
Light
2/10
Low stimulation, euphoria, and focus with strong anxiety/jitters
Stimulation / Energy
×3
3
stimulation
Euphoria / Mood Lift
×2
3
euphoria
Focus / Productivity
×2
2
analysis enhancement
Anxiety / Jitters
×1
10
anxiety
restlessness
increased heart rate
vasoconstriction
muscle tension
Based on reports from:
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute; 1–3 weeks for full reset
Tolerance Decay
Full tolerance
1d
Half tolerance
3d
Baseline
~21d
Tolerance patterns extrapolated from LSD/2C-x data: marked acute tachyphylaxis with partial recovery over 3–7 days and near-baseline by ~1–2 weeks, though exact values for MEM are unstudied.
Cross-Tolerances
Other classical psychedelics (phenethylamines and tryptamines)
Effects
Effect glossary — · full glossary
Positive
Negative
Positive
Negative
- Change in perception
Positive
Negative
- Closed/Open eye visuals
Combinations
Cross-Check MEM with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Bluelight 1 thread 1 cautionary visit
PiHKAL / TiHKAL
PiHKAL #122: MEM
“I experienced some physical discomfort, but doesn’t that tell us about the work to be done, rather than the property of the material? The breakthrough I had was the following day (and this seems to be the way MEM operates, i.e., first the energy and expansion, next day insight) was of the highest value and importance for me. I was given a methodology for dealing with my shadow parts. No small gift. And I did it all alone and the results were immediate. I am so grateful.”
MEM's nerd page
Pharmacology, chemical data, effect profiles, and more
→
Helpful Links
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track MEM there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
⬇ Download import file
Import this file as custom substances
and you get "MEM (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer. The manual values below work for older
versions.
Name
MEM
Unit
mg
Description
MEM Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 15 · light 15-25 · common 25-35 · strong 35-45+ · heavy 45+ Oral duration: onset 0.5-1.5h · come-up 1-2h · peak 3-6h · offset 3-6h · total 8-16h · after-effects 24h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 30 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for MEM? Let us know. Reports are reviewed by moderators — this is not posted publicly.