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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    MDPA Limited data
    Limited data
    Sparse data. Doses and effects may be unreliable or untested.
    • 1 source
    • 1 ROA with full dose ladder
    • duration data present
    • classified Tentative
    • classified Research-chemical

    Aliases: Methylenedioxyphenylacetamide

    Psychedelic Empathogen Research-chemical

    Summary TripSit

    An obscure substituted methylenedioxyphenethylamine with practically no history of human use. Its pharmacological profile is largely unknown, but potentially exhibits similar properties to other MDxx compounds. May be a monoamine releaser, reuptake inhibitor or both.

    Dose Information dose.wiki TripSit

    ROA Light Common Strong Heavy
    Oral 75-125mg 125-175mg 175-250mg 250+mg
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — dose.wiki, TripSit

    Onset, Duration & After-effects TripSit

    ROA Onset Peak Total
    Oral 15-45 min 2-4 hrs 2-4 hrs

    Effect Profile

    Scores (0–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 3.5
    Moderate 4/10

    Moderate visuals with strong body load, low headspace

    Visual Intensity ×3
    6
    color enhancement tracers pattern recognition enhancement visual distortions
    Headspace Depth ×3
    3
    introspection time distortion
    Auditory Effects ×1
    0
    ⚠ Body Load / Somatic Effects ×1
    9
    nausea vasoconstriction teeth grinding increased heart rate sweating
    Empathogen 4.6
    Moderate+ 5/10

    Moderate stimulation, sensory enhancement, and euphoria with low empathy

    Empathy / Social Openness ×3
    2
    increased sociability
    Euphoria / Mood Elevation ×2
    6
    euphoria cognitive euphoria
    Stimulation ×1
    7
    stimulation wakefulness teeth grinding increased heart rate
    Sensory Enhancement ×1
    7
    tactile enhancement color enhancement increased libido
    View methodology →

    Effects

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    MDPA's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📖 TripSit
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track MDPA there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "MDPA (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    MDPA
    Unit
    mg
    Description 
    MDPA
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): light 75-125 · common 125-175 · strong 175-250 · heavy 250+

Oral duration: onset 15-45m · peak 2-4h · total 2-4h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 150 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.