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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    MD-prolintane Limited data
    Limited data
    Sparse data. Doses and effects may be unreliable or untested.
    • 1 source
    • duration data present
    • 29 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: Methylenedioxyprolintane

    Stimulant Research-chemical

    Summary dose.wiki

    MD-prolintane is the 3,4-methylenedioxy analogue of prolintane and structurally the de-ketone counterpart of MDPV. Users describe functional, cocaine-like stimulation with reduced peripheral tension compared to alpha-PVP. Duration is approximately 4-6 hours with reports of smoother comedowns than related pyrrolidinophenones.

    Dose Information DrugsPRO

    ROA Threshold
    Oral 2mg
    Insufflated 2mg
    Vaporized / Smoked 2mg
    Intravenous 1mg

    Only a threshold dose is documented for this substance — the smallest amount with a noticeable effect. There is no published light/common/strong ladder to show above it.

    Sources

    Oral

    Dose ladder — DrugsPRO

    Insufflated

    Dose ladder — DrugsPRO

    Vaporized / Smoked

    Dose ladder — DrugsPRO

    Intravenous

    Dose ladder — DrugsPRO

    Onset, Duration & After-effects dose.wiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 20-40 min 30-60 min 1-3 hrs 1-2 hrs 2-12 hrs 2.83-6.67 hrs
    Insufflated 5-10 min 10-20 min 1-3 hrs 1-2 hrs 2-12 hrs 2.25-5.5 hrs
    Vaporized / Smoked 2 min 5-10 min 1-3 hrs 1-2 hrs 2-12 hrs 2.11-5.2 hrs
    Intravenous 1 min 1-5 min 1-3 hrs 1-2 hrs 2-12 hrs 2.04-5.1 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 6.1
    Strong 6/10

    Strong euphoria and anxiety/jitters with moderate focus, mild stimulation

    Stimulation / Energy ×3
    5
    stimulation wakefulness
    Euphoria / Mood Lift ×2
    10
    physical euphoria cognitive euphoria euphoria motivation enhancement
    Focus / Productivity ×2
    7
    focus enhancement motivation enhancement thought acceleration
    ⚠ Anxiety / Jitters ×1
    10
    anxiety paranoia increased heart rate teeth grinding vasoconstriction sweating
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute; 1–3 weeks for full reset

    Tolerance Decay

    Full tolerance 1d Half tolerance 12d Baseline ~21d

    Effects dose.wiki

    Positive
    Negative
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral

    Combinations

    Cross-Check MD-prolintane with another substance

    MD-prolintane's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track MD-prolintane there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    Name
    MD-prolintane
    Unit
    mg
    Description 
    MD-prolintane
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 2
Insufflated dose (mg): threshold 2
Vaporized / Smoked dose (mg): threshold 2
Intravenous dose (mg): threshold 1

Oral duration: onset 20-40m · come-up 0.5-1h · peak 1-3h · offset 1-2h · total 2.83-6.67h · after-effects 2-12h
Insufflated duration: onset 5-10m · come-up 10-20m · peak 1-3h · offset 1-2h · total 2.25-5.5h · after-effects 2-12h
Vaporized / Smoked duration: onset 2m · come-up 5-10m · peak 1-3h · offset 1-2h · total 2.11-5.2h · after-effects 2-12h
Intravenous duration: onset 1m · come-up 1-5m · peak 1-3h · offset 1-2h · total 2.04-5.1h · after-effects 2-12h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.