Lisdexamfetamine Well-documented

Well-documented

Multiple authoritative sources agree on dosing and effects.

3 corroborating sources

1 ROA with full dose ladder

duration data present

29 combo interactions documented

toxicity data (PsychonautWiki)

Aliases: Vyvanse, Elvanse, Tyvense, Lisdextroamphetamine, lisdextroamfetamine, lisdexamphetamine

Summary dose.wiki

Lisdexamfetamine is a prodrug that is inactive until enzymatically converted to dextroamphetamine by red blood cells. This design provides extended-release effects lasting 10-14 hours and theoretically reduces abuse potential, as insufflation or injection does not accelerate onset. Approved for ADHD in adults and children 6+ years, and for binge eating disorder in adults.

Dose Information source varies by band

ROA	Light	Common	Strong	Heavy
Oral	20-30mg	30-60mg	60-90mg	90mg+

Light Common Strong Heavy

Sources

Oral

Dose ladder — Light: dose.wiki, PsychonautWiki · Common–Heavy: dose.wiki, PsychonautWiki; PsychonautWiki's and dose.wiki's Threshold (10 mg) differs from ours (5 mg)

Onset, Duration & After-effects dose.wiki PsychonautWiki FDA

ROA	Onset	Comeup	Peak	Offset	After Effects	Total
Oral	1-2 hrs	30-60 min	3-5 hrs	4-6 hrs	2-6 hrs	8.5-14 hrs

Effect Profile

51 reports

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Validated against 51 Erowid trip reports
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Stimulant 8.8

Intense+ 9/10

Strong stimulation, euphoria, focus, and anxiety/jitters

Stimulation / Energy ×3

stimulation wakefulness

Euphoria / Mood Lift ×2

physical euphoria cognitive euphoria euphoria motivation enhancement

Focus / Productivity ×2

focus enhancement analysis enhancement motivation enhancement thought acceleration

⚠ Anxiety / Jitters ×1

anxiety increased heart rate

Based on reports from:

Erowid Experience Reports

Tolerance

Build-up develops over days to weeks of regular use

Reset 3–7 days for acute; 1–3 weeks for full reset

Tolerance Decay

Full tolerance 7d Half tolerance 14d Baseline ~28d

Clinical and community data indicate noticeable tolerance with repeated daily dosing within days, and partial reversal after several weeks of abstinence. Quantitative values are heuristic for harm‑reduction planning, not prescriptive dosing guidance.

Cross-Tolerances

Amphetamines

Other stimulants

Effects Erowid

Aggregated from 51 Erowid experience reports

Each bar shows the share of analyzed reports whose text mentions that effect — a mention is not always a first-hand experience (fear of an effect, something witnessed, or "did not happen" count too). Tap or hover any number for details. The second value is the Bluelight extractor's per-effect confidence; a dash means the row is Erowid-derived, which has no confidence measurement.

Positive Effects 9

68.6% –

62.7% –

52.9% –

37.3% –

27.5% –

19.6% –

13.7% –

11.8% –

5.9% –

Adverse Effects 10

49.0% –

19.6% –

17.6% –

15.7% –

7.8% –

5.9% –

Combinations

Cross-Check Lisdexamfetamine with another substance

Community Trip Reports

Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.

Erowid 8 reports 3 positive 5 neutral visit

A Lovely Wonderful Drug positive exp #107414

I obtained a 50mg capsule of Vyvanse, and decided to split it, since I really have no focus problems at all I just wanted to see what it was like. I had tried 20mg before (I tried to split it evenly but I failed) and it was very pleasant, so I was expecting the same experience, more or less.

A Perfect Mix of Motivation and Comfort positive exp #77839

Background: Generally, I'm not too experienced in drugs so far. I've smoked quite a bit of weed in my life, drank a few times, snorted hydrocodone / Vicodin (not recommended), and snorted Ritalin and Adderall. The only drugs out of these that I've used repeatedly are weed and Vicodin.

A Recovering Addicts Take on Vyvanse neutral exp #89651

Background Im a recovering addict so I havent consumed any intoxicating substances in the past 5 months. I smoked marijuana and hash habitually (multiple times a day) for the past 2 years, I have experience with psychadelics (LSD, psilocybin containing mushrooms, MDMA, and salvia dinorum), and Ive abused various p...

I Needed to Be Very Productive neutral exp #94916

Midterm and Vyvanse Here is the context of this experience report. Its the first time I ever took Amphetamine. I took it because I needed to be very productive to finish a mid-term paper and I usually have a lot of trouble to concentrate on this kind of work so I figured the Vyvanse would help.

I Was Invincible neutral exp #98236

Let me begin by saying I have experimented with several drugs including weed, alcohol, ecstasy, and prescription pills (Xanax, Adderall, Ritalin, Methadone). This entry is about the prescription medication, Vyvanse. It isnt my prescription, it is my brothers.

I Had Fun Studying While on It positive exp #71489

Vyvanse, an Adderrall Alternative I have tried most things out there for ADHD, being a college student, and have a prescription for Vyvanse now. I personally think that it is one of the best to aid in any attempt to make my concentration increase.

Day Routine neutral exp #107521

The end of the semester again approaches. A couple 50mg Vyvanse capsules make their way into my possession because of a good friend. My past experiences with stimulants have been, on the whole, very horrific and negative.

Semi-Clinical Use for Brian Fog neutral exp #109096

I wanted to try lisdexamfetamine for a few reasons: Clinically, I've dealt with a hodgepodge of eating disordered behavior over the years, including binge eating disorder, and Vyvanse was recently approved to treat this. I don't meet the clinical criteria but binge often enough that it was a concern to me.

Bluelight 8 threads 7 neutral 1 cautionary visit

Vyvanse Experienced Trip Report neutral

(I'm new to the site and looking for advice on where to but this thread which is about my small amount of experience of using Vyvanse recreational and some questions.) [h=2]tl;dr short one: I'm confused that Vyvanse makes me feel drunk and not focus when it should, why? what are the mental and physical side effects of...

140 Mg Vyvanse Lisdexamfetamine Low Tolerance Bonding With The School Cop neutral

I have previously taken adderall and ritalin every couple months or so when I have the ability to acquire them I absolutely love taking them at school due to the obvious side effects of increased sociability and concentration.

Adhd Tabs Elvanse 100mg Intermediate A Surprisingly Uplifting Trip neutral

Hello, thought I should share my trip report with you all because it wasn't what I expected! I will give you a little background info. I am prescribed as follows- Elvanse 50mg (ADHD), Quetiapine 100mg (Anxiety), Promethazine 50mg (Sleep). All medications usually taken daily and as prescribed.

Vyvanse 140 Mg Semi Experienced neutral

Ok, this is my first trip report so lets give it a try. Im probably 6ft 220Lbs pretty muscular Two days ago my friend calls me up asking if i knew where to get some adderall. Right off the top of my head i knew a guy that could hook me up so i gave him a call. He told me he could give me 4 vyvanse 70mg.

Vyvanse Experienced 70mg 1 2 3 Quantities neutral

Decided to do a test on how much I may tweak by adding a pill a week. In this report I will be using 70mg vyvanse each week and adding more 1 per week. I will not be using vyvanse during the week for tolerance issues. 1st Week, Dosage : 70mg. Prescription based.

Vyvanse 60mg Moderate Experience Using Trypsin To Convert Lisdexamphetamine neutral

Hey, I'm new to Bluelight so I'd love some feedback on this report as this is my first on this forum. My friend Joe had heard on another forum that one can bypass the "extended release" portion of vyvanse by cleaving the l-lysine portion of the molecule off with an enzyme supplement containing Trypsin.

Vyanse Lisdexamphetamine 300mg Experienced Flex For 20hours neutral

Vyanse 300mg (10 x 30mg capsules in one go). Experienced: Make sure your mind is in a good place I got to say I'm quite used to amphetamines of all sorts and I'm almost always able to never over do it as dosage wise, but this time I didn't.

Vyvanse 210mg First Time First Time Taking Vyvanse cautionary

Ok so this is my first post, so please don't judge any mistakes I make. So this was my first time trying an amphetamine, so I tried vyvanse. Normally I spend a long time studying a drug before I use it, been like that since I overdosed on pills and went to the hospital when I first got into drugs.

Pill Identifiers

8 known pill identifiers on record — view imprints, colors, shapes, and images

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Lisdexamfetamine's nerd page Pharmacology, chemical data, effect profiles, and more

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Helpful Links

📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki

Import into PsychonautWiki Journal

The PsychonautWiki Journal app includes Lisdexamfetamine, but its built-in data can be thinner than ours. Importing this file adds a separate "Lisdexamfetamine (Substance Search)" custom substance with our dose ranges, durations and tolerance, so you can log against whichever you prefer.

⬇ Download import file Import this file as custom substances and you get "Lisdexamfetamine (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer.

Ranges are harm-reduction guidance, not a prescription.

Report an issue or suggest an edit

Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for Lisdexamfetamine? Let us know. Reports are reviewed by moderators — this is not posted publicly.

Lisdexamfetamine Well-documented Well-documented Multiple authoritative sources agree on dosing and effects. 3 corroborating sources 1 ROA with full dose ladder duration data present 29 combo interactions documented toxicity data (PsychonautWiki)